CAS: 469-83-0; Cafestol
该化合物是天然化合物,主要是咖啡,特别是未过滤的咖啡酿制中的咖啡;它是一种二极管,具体地说是一种低脂类,以脂类结构著称;咖啡因其潜在的健康影响而得到承认,包括提高血液胆固醇含量的能力,这是咖啡消费和心血管健康研究的一个课题;该化合物的抗氧化性特性也值得注意,有助于与咖啡相关的总体健康惠益;咖啡溶剂在有机溶剂中可溶,但水溶性有限,许多脂类化合物都常见,咖啡中的溶性差异很大,取决于酿酒方法;例如,法国报刊或土耳其咖啡等方法与过滤咖啡相比,保留了更多的咖啡.了解咖啡厅的特性对于评价其对健康和营养的影响以及它在咖啡复杂化学中的作用至关重要.
- 英文名称Cafestol
- 中文名称咖啡醇
- IUPAC名称(3bS,5aS,7R,8R,10aR,10bS)-7-(Hydroxymethyl)-10b-methyl-3b,4,5,6,7,8,9,10,10a,10b,11,12-dodecahydro-5a,8-methanocyclohepta[5,6]naphtho[2,1-b]furan-7-ol
- 其它别名CAFESTEROL; CAFESTOL; 3bα,4,5,6,7,8,9,10,10aα,10b,11,12-Dodecahydro-7β-hydroxy-10bβ-methyl-5aβ,8β-methano-5aH-cyclohepta[5,6]naphtho[2,1-b]furan-7α-methanol; 5A,8-Methano-5ah-cyclohepta(5,6)naphtho(2,1-B)furan-7-methanol, 3B,4,5,6,7,8,9,10,10A,10B,11,12-dodecahydro-7-hydroxy-10B-methyl-, (3bs-(3balpha,5abeta,7beta,8beta,10aalpha,10bbeta))-; 5A,8-Methano-5ah-cyclohepta(5,6)naphtho(2,1-B)furan-7-methanol, 3B,4,5,6,7,8,9,10,10A,10B,11,12-dodecahydro-7-hydroxy-10B-methyl-, (3bs,5as,7R,8R,10ar,10bs)-; CAFESTOL(SH)
- CAS编号469-83-0
- MFCD编号:MFCD01075769
- FDA UNII编号:AC465T6Q6W
- 分子式:C20H28O3分子量:316.43
- 产品CID: 1464806
- 产品分类有机原料 → 有机杂环化合物 → 萘并呋喃类
物理性质
MSDS等安全信息
合成工艺路线路线简述
📜Alkaline Earth Salt Of/the/ Methylsulfuric Acid置于乙醇,Sodium体系中,化学反应生成 咖啡醇
参考文献:Wettstein Et Al.,Helvetica Chimica Acta,1945,Vol. 28,P. 1004,1008,1010
标题:Wettstein Et Al.,Helvetica Chimica Acta,1945,Vol. 28,P. 1004,1008,1010
海关参考信息
- 2905122000-异丙醇
2905143000-叔丁醇
2905310000-1,2-乙二醇
2905320000-1,2-丙二醇 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:WO-2017046598-A1
优先权日:2015-09-16
标题:Treatment of acute inflammatory disorders
发明人：CRISANTI ANDREA; CANAVESE MIRIAM
权利人:CRISANTI ANDREA; IMP INNOVATIONS LTD
摘要:The present invention relates to a VEGF receptor agonist for use in the treatment of an acute inflammatory disorder associated with the overproduction of pro-inflammatory cytokine, administered with an agent that induces the synthesis of Nrf2. The invention also relates to pharmaceutical combinations comprising a VEGF receptor agonist and an agent that induces the synthesis of Nrf2, and kits comprising these agents. The described uses, combinations and methods may prevent or reduce the dis-regulated activation of an inflammatory response and reduce endothelial damage.
专利号:WO-2022132102-A1
优先权日:2020-12-16
标 题:Method of manufacturing cafestol-loaded biopolymer nanoparticles
发明人：YILDIRIM YELIZ; VARDAR ÖZGE
权利人:EGE UENIVERSITESI
摘要:The invention relates to the synthesis of cafestol -loaded chitosan and alginate biopolymer nanoparticles that have been synthesized for use in diabetes and cancer diseases and in-vitro release studies of which have been conducted.
专利号:US-5855897-A
优先权日:1996-09-13
标题 :Topical composition and method for enhancing lipid barrier synthesis
发明人：PELLE EDWARD
权利人:E L MANAGEMENT CORP
摘要:The present invention relates to topical compositions useful in enhancing lipid synthesis in skin comprising an effective amount of cafestol, in combination with a pharmaceutically or cosmetically acceptable carrier. Such compositions are useful in treatment or prevention of dry skin and conditions in which the skin's lipid barrier is defective or damaged.
专利号:US-5900227-A
优先权日:1996-06-17
标题 :Multicyclic nitrone spin trapping compositions
发明人：JANZEN EDWARD G; SANKURATRI NAGARAJU
权利人:OKLAHOMA MED RES FOUND
摘要:Multicyclic nitrone spin trapping compounds capable of forming stable free radical spin adducts are provided as well as methods for their synthesis. The multicyclic nitrone spin trapping compounds can be reacted with a free radical, such as a hydroxy or hydroperoxy radical, in solution to form a spin adduct which is stable and readily detectable by electron paramagnetic resonance (EPR) spectroscopy. The multicyclic nitrone spin traps can be used to detect free radicals in a sample such as a biological system. In one embodiment, the spin trapping compound, 1,3,3-trimethyl-6-azabicyclo-[3.2.1]oct-6-ene-N-oxide ('TRAZON') is provided, as well as methods for the synthesis of TRAZON and of modified forms of TRAZON. TRAZON can react with a wide range of different free radicals in solution to form free radical spin adducts which are readily detectable by EPR.
专利号:US-6716437-B1
优先权日:1993-09-13
标 题:Topical composition and method for enhancing lipid barrier synthesis
发明人：PELLE EDWARD; ANDERSON JON
权利人:E L MANAGEMENT CORP
摘要:The present invention relates to topical compositions useful in enhancing lipid synthesis in skin comprising an effective amount of cafestol or kahweol, or derivative thereof, in combination with a pharmaceutically or cosmetically acceptable carrier. Such compositions are useful in treatment or prevention of dry skin and conditions in which the skin's lipid barrier is defective or damaged.
专利号:US-2024335497-A1
优先权日:2021-07-26
标题 :Pulse protein-based composition for activating the synthesis of fgf19
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: van Dam RM, Hu FB, Willett WC. Coffee, Caffeine, and Health. N Engl J Med. 2020 Jul 23;383(4):369-378. doi: 10.1056/NEJMra1816604. 20(17):4238. doi: 10.3390/ijms20174238.
3: Eldesouki S, Qadri R, Abu Helwa R, Barqawi H, Bustanji Y, Abu-Gharbieh E, El- Huneidi W. Recent Updates on the Functional Impact of Kahweol and Cafestol on Cancer. Molecules. 2022 Oct 28;27(21):7332. doi: 10.3390/molecules27217332.
4: Butt MS, Sultan MT. Coffee and its consumption: benefits and risks. Crit Rev Food Sci Nutr. 2011 Apr;51(4):363-73. doi: 10.1080/10408390903586412. 23(7):38. doi: 10.1007/s11906-021-01156-3.
合成参考文献
参考文献:10.1042/bst0240800
摘要:Urgert R, Kosmeijer-Schuil TG, Katan MB. Intake levels, sites of action and excretion routes of the cholesterol-elevating diterpenes from coffee beans in humans. Biochem Soc Trans. 1996 Aug;24(3):800–6. doi: 10.1042/bst0240800.
参考文献:10.1055/s-0035-1558084
摘要:Guzzo LS, Castor MG, Perez Ade C, Duarte ID, Romero TR. Natural Diterpenes from Coffee, Cafestol, and Kahweol Induce Peripheral Antinoceception by Adrenergic System Interaction. Planta Med. 2016 Jan;82(1-2):106–12. doi: 10.1055/s-0035-1558084.
参考文献:10.1021/acs.jnatprod.5b00481
摘要:Mellbye FB, Jeppesen PB, Hermansen K, Gregersen S. Cafestol, a Bioactive Substance in Coffee, Stimulates Insulin Secretion and Increases Glucose Uptake in Muscle Cells: Studies in Vitro. J Nat Prod. 2015 Oct 23;78(10):2447–51. doi: 10.1021/acs.jnatprod.5b00481.
参考文献:10.1093/ajcn/65.2.519
摘要:Urgert R, Essed N, van der Weg G, Kosmeijer-Schuil T, Katan M. Separate effects of the coffee diterpenes cafestol and kahweol on serum lipids and liver aminotransferases. The American Journal of Clinical Nutrition. 1997 Feb;65(2):519–24. doi: 10.1093/ajcn/65.2.519.
参考文献:10.1021/jf980934v
摘要:Ruiz del Castillo ML, Herraiz M, Blanch GP. Rapid analysis of cholesterol-elevating compounds in coffee brews by off-line high-performance liquid chromatography/high-resolution gas chromatography. J Agric Food Chem. 1999 Apr;47(4):1525–9. doi: 10.1021/jf980934v.
📝 需求与反馈
尽可能描述清楚需求与问题信息
