CAS: 455-88-9; 1-Fluoro-2-Methyl-4-Nitrobenzene

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CAS号13290-74-9 2-氯-5-硝基甲苯 | CAS号95-52-3 邻氟甲苯 | CAS号7149-70-4 2-溴-5-硝甲苯 | CAS号1195931-64-6 2-methyl-4-nitr... | CAS号99-99-0 对硝基甲苯 | CAS号99-08-1 3-硝基甲苯 | CAS号7697-37-2 硝酸 | CAS号50741-92-9 2-甲氧基-5-硝基苯甲醚 | CAS号394-30-9 5-氯-2-氟苯甲酸 | CAS号495-07-8 2,5-二氟苄氯 | CAS号147285-88-9 4-fluoro-3-meth... | CAS号452-67-5 2,5-二氟甲苯 | CAS号452-68-6 2-氟-5-碘甲苯 | CAS号452-69-7 4-氟-3-甲基苯胺 | CAS号452-66-4 5-氯-2-氟甲苯 | CAS号201157-13-3 N-苄基-2-甲基-4-硝基苯胺 | CAS号97389-11-2 4-氟-5-甲基邻苯二胺

2-氯-5-硝基甲苯置于(1,5-环辛二烯)二(三甲基硅烷基甲基)钯(II),2-(二环己基膦)3,6-二甲氧基-2',4',6'-三异丙基-1,1'-联苯 Silver Fluoride体系中,用 甲苯 作为反应溶剂,化学反应 12.0H,以90%的收率获得产物2-氟-5-硝基甲苯
参考文献:Metal-Catalyzed Carbon-Fluorine Bond Formation
标题:Metal-Catalyzed Carbon-Fluorine Bond Formation
摘要:该发明的一个方面涉及将芳基卤化物和磺酸酯金属催化转化为相应的芳基氟化物.该发明的另一个方面涉及将杂环芳基卤化物和磺酸酯金属催化转化为相应的杂环芳基氟化物.该发明的另一个方面涉及将乙烯卤化物和磺酸酯金属催化转化为相应的乙烯氟化物.在某些实施例中,使用简单的氟化物源,如agf和csf.在某些实施例中,这些转化可以容忍各种官能团,从而使高度官能化的有机分子中引入氟原子成为可能.

专利信息

专利号:WO-9925385-A1
优先权日:1997-11-17
标 题:A method of increasing nucleic acid synthesis with ultrasound
发明人：UNGER EVAN C; MCCREERY THOMAS; SADEWASSER DAVID
权利人:IMARX PHARMACEUTICAL CORP
摘要:The present invention is directed to a method of increasing nucleic acid synthesis in a cell comprising administering to the cell a therapeutically effective amount of ultrasound for a therapeutically effective time such that said administration of said ultrasound results in said increased nucleic acid synthesis. The nucleic acid sequence may comprise an endogenous sequence or an exogenous sequence.

专利号:US-2009192315-A1
优先权日:2006-07-06
标题 :Synthesis of heterocyclic compounds

专利号:US-10227344-B2
优先权日:2016-06-24
标题 :CK2 inhibitors, compositions and methods thereof
发明人：WEBBER STEPHEN E; TAO XUELIANG; BRIN ELENA
权利人:POLARIS PHARMACEUTICALS INC
摘要:The present invention provides synthesis, pharmaceutically acceptable formulations and uses of compounds in accordance with Formula (I), or a stereoisomer, a tautomer or a pharmaceutically acceptable salt thereof. n nFor Formula (I) compounds R 1 , R 2 , R 3 , Ar and Z are as defined in the specification. The inventive Formula (I) compounds are inhibitors of CK2 and find utility in any number of therapeutic applications, including but not limited to treatment of proliferative disorders such as cancer, inflammation and immunological disorders.

专利号:RU-2200153-C2
优先权日:1997-01-24
标 题 :Aminobenzophenones, method of their synthesis, pharmaceutical preparation, method of treatment and prophylaxis of skin inflammatory diseases

专利号:CN-111825604-A
优先权日:2019-04-16
标题 :Synthesis method of cartinib and intermediate product thereof

专利号:RU-2195455-C2
优先权日:1995-04-11
标 题 :Substituted 1-phenyl-3-carboxamides and their pharmaceutically acceptable salts, method of their synthesis, intermediate compounds and pharmaceutical composition based on thereof showing affinity to human neurotensin receptors