CAS: 4286-15-1; (S)-2-Phenylbutanoic Acid

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CAS号865363-42-4 2,2-diphenylvin... | CAS号90-27-7 2-苯基丁酸 | CAS号852336-21-1 2-(tert-butyl)p... | CAS号62784-66-1 二-1-萘甲醇 | CAS号103-82-2 苯乙酸 | CAS号75-03-6 碘乙烷 | CAS号20452-67-9 1-Buten-1-one, ... | CAS号93-55-0 苯丙酮 | CAS号33603-06-4 (S)-2-Phenylbut...

📜2-苯基丁酸 以43.0 G的收率获得产物s(+)-2-苯基丁酸
参考文献:1-[4-[2-[2-(二甲基氨基)乙氧基]苯基]-1,2-二苯基丁烷(二氢他莫昔芬)的非对映异构体和对映异构体的合成,构象考量和雌激素受体结合.
标题:1-[4-[2-[2-(二甲基氨基)乙氧基]苯基]-1,2-二苯基丁烷(二氢他莫昔芬)的非对映异构体和对映异构体的合成,构象考量和雌激素受体结合.
摘要:作为对不可异构的抗雌激素的研究的一部分,非对映异构体二氢他莫昔芬7和8是通过(z)-和(e)-他莫昔芬的催化转移加氢制备的,并通过NMR光谱法显示与氢原子呈优选的构象,且呈反周平面关系存在.由(z)-和(e)-4-羟基他莫昔芬的氢化前体制备相应的4-羟基衍生物9和10.化合物与雌激素受体的相对结合亲和力(rba)与指定的构象和有关非甾体雌激素己烯雌酚衍生物的平行报道数据一致.体外对mcf-7人乳腺癌细胞系的生长抑制活性相当于4-羟基他莫昔芬的10倍,尽管将浓度从10(-8)m增加到10(-6)m并不能显着改善生长抑制.类似于(e)-4-羟基他莫昔芬的衍生物9拮抗添加的雌二醇的生长刺激作用,因此也是抗雌激素药,但是在没有雌二醇的情况下(10(-8)m)低浓度,Mcf-7细胞生长被刺激,表明雌激素的影响.由2-苯基丁酸的拆分对映体分别制备二氢他莫昔芬8的对映体,关键反应步骤是将锂的氨氨还原成1
DOI:10.1021/jm00393A014

专利信息

专利号:US-5248815-A
优先权日:1991-12-27
标 题 :Stereo-selective synthesis of 2-aryl-propionic acids of high optical purity by using chiral oxazolines
发明人：PARADIES HENRICH H
权利人:PARADIES HENRICH H
摘要:The present invention relates to a stereospecific chemical synthesis of optically pure enantiomers of 2-aryl-alkanoic acids, especially those of the biologically active (S)-aryl-propionic acids, in good chemical yields, useful for preparing large quantities thereof, and having a high optical purity.

专利号:US-5521281-A
优先权日:1995-04-18
标题 :Substantially isotactic, linear, alternating copolymers of carbon monoxide and an olefin
发明人：SEN AYUSMAN; JIANG ZHAOZHONG
权利人:PENN STATE RES FOUND
摘要:The compound, [Pd(Me-DUPHOS)(MeCN)2](BF4)2, [Me-DUPHOS: 1,2-bis(2,5-dimethylphospholano)benzene] is an effective catalyst for the highly enantioselective, alternating copolymerization of olefins, such as aliphatic alpha -olefins, with carbon monoxide to form optically active, isotactic polymers which can serve as excellent starting materials for the synthesis of other classes of chiral polymers. For example, the complete reduction of a propylene-carbon monoxide copolymer resulted in the formation of a novel, optically active poly(1,4-alcohol). Also, the previously described catalyst is a catalyst for the novel alternating isomerization cooligomerization of 2-butene with carbon monoxide to form optically active, isotactic poly(1,5-ketone)

专利号:WO-9313046-A1
优先权日:1991-12-27
标题:Stereo-selective synthesis of 2-aryl-propionic acids of high optical purity by using chiral oxazolines

专利号:US-9676676-B2
优先权日:2014-07-02
标题 :Selective olefin metathesis with cyclometalated ruthenium complexes
发明人：HARTUNG JR JOHN; QUIGLEY BRENDAN L; DORNAN PETER K; GRUBBS ROBERT H
权利人:CALIFORNIA INST OF TECHN
摘要:This invention relates generally to C—H activated ruthenium olefin metathesis catalyst compounds which are stereogenic at the ruthenium center, to their preparation, and the use of such catalysts in the metathesis of olefins and olefin compounds. In particular, the invention relates to the use of C—H activated ruthenium olefin metathesis catalyst compounds in Z-selective olefin metathesis reactions, enantio-selective olefin metathesis reactions, and enantio-Z-selective olefin metathesis reactions. The invention has utility in the fields of catalysis, organic synthesis, polymer chemistry, and industrial and fine chemicals chemistry.

专利号:EP-0641304-A4
优先权日:1991-12-27
标题:STEREOSPECIFIC SYNTHESIS OF 2-ARYL-PROPIONIC ACIDS OF HIGH OPTICAL PURITY USING CHIRAL OXAZOLINES.

专利号:EP-0641304-B1
优先权日:1991-12-27
标题:Stereo-selective synthesis of 2-aryl-propionic acids of high optical purity by using chiral oxazolines