CAS: 3986-89-8; 3-Oxobisnor-20-Iso-4-Cholen-22-Al
该化合物是一种具有独特结构特征的抗血清化合物,其特点是具有独特的结构特征,包括3号位置的氯酮组,4和5号位置之间的双联体和22号位置上的甲状腺功能组,该化合物属于胆固醇的衍生物,具有典型类固醇特征的复杂环状结构,其分子框架有助于其潜在的生物活动,尤其是与类固代谢和荷尔蒙功能有关的生物活动.双联和甲状胺组的存在可能会影响其再活动以及与生物系统的互动.作为类固态,它也可能在各种生物化学途径中发挥作用,包括与细胞信号和膜结构有关的道路.然而,具体的生物活动和应用需要通过实验研究作进一步调查.总体而言,3-oxo-23,24-dinorchol-4-en-22-al是类固化细胞中的一种重要化合物,对化学和生物化学和生化学都具有影响.
物理性质
MSDS等安全信息
上下游产品
24β-Methylcholesta-4,22E-Dien-3-One 4030-92-6豆固酮 (22E)-Stigmasta-4,22-Dien-3-One 20817-72-5
(20S)-21-羟基-20-甲基孕甾-4-烯-3-酮 (20S)-20-Hydroxymethylpregn-4-En-3-One 40736-33-2
豆甾醇 Stigmasterol 83-48-7
合成工艺路线路线简述
- 合成目标产物 Bisnorcholenaldehyde 主要起始原料 3-Keto-23,24-Bisnorchol-4-En-22-Ol
- (文献来源)合成步骤主要原料 3-Keto-23,24-Bisnorchol-4-En-22-Ol
📜豆甾醇置于氧气,环己酮,Aluminum Isopropoxide,臭氧体系中,用 二氯甲烷,甲苯 作为反应溶剂,化学反应 1.13H,反应生成 二去甲胆烯醛
参考文献:Structure And Synthesis Of A Progesterone Homologue From The Skin Of The Dorid Nudibranchaldisa Smaragdina
标题:Structure And Synthesis Of A Progesterone Homologue From The Skin Of The Dorid Nudibranchaldisa Smaragdina
摘要:
DOI:10.1002/1099-0690(200205)2002:9<1500::Aid-Ejoc1500>3.0.Co;2-D
海关参考信息
- 2901210000-乙烯
2901220000-丙烯
2912110000-甲醛
2912120000-乙醛 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-11479577-B2
优先权日:2016-05-18
标题:Intermediates for the synthesis of bile acid derivatives, in particular of obeticholic acid
发明人：WEYMOUTH-WILSON ALEXANDER; KOMSTA ZOFIA; WALLIS LAURA; EVANS TIMOTHY; DAVIES IEUAN; OTTER CARL; BATCHELOR RHYS
权利人:NZP UK LTD
摘要:The present invention relates to compounds which are intermediates in the synthesis of bile acid derivatives with pharmacological activity. The invention relates to compounds of general formula (I):wherein:, R1, R2, R3, R4, R5, R6 and Y are as defined herein.The compounds are intermediates in the synthesis of synthetic bile acids which are useful in the treatment of conditions such as liver disease. In addition, the invention relates to a method of synthesizing these intermediates and a method of preparing obeticholic acid and obeticholic acid analogues from the compounds of the invention.
专利号:US-10766921-B2
优先权日:2016-05-18
标 题 :Process and intermediates for the 6,7-alpha-epoxidation of steroid 4,6-dienes
发明人：WEYMOUTH-WILSON ALEXANDER; KOMSTA ZOFIA; WALLIS LAURA; EVANS TIMOTHY
权利人:NZP UK LTD
摘要:The invention relates to a process for preparing a compound of general formula (Ia): wherein R2, Y, R4 and R5 are as defined herein, wherein the epoxidation is conducted using an oxidant and methyltrioxorhenium as a catalyst (MeReO3). The invention also relates to certain compounds per se. The compounds are intermediates in the synthesis of synthetic bile acids.
专利号:US-6133280-A
优先权日:1997-02-05
标题 :Androgen synthesis inhibitors
发明人：BRODIE ANGELA; LING YANGZHI
权利人:UNIV MARYLAND
摘要:This invention relates to novel inhibitors of androgen synthesis that are useful in the treatment of prostate cancer and benign prostatic hypertrophy. The present invention also provides methods of synthesizing these novel compounds, pharmaceutical compositions containing these novel compounds, and methods of treating prostate cancer and benign prostatic hypertrophy using the androgen synthesis inhibitors of the present invention.
专利号:US-2019284227-A1
优先权日:2016-05-18
标题:Intermediates for the Synthesis of Bile Acid Derivatives, in Particular of Obeticholic Acid
专利号:WO-2017199033-A1
优先权日:2016-05-18
标题:Intermediates for the synthesis of bile acid derivatives, in particular of obeticholic acid
专利号:US-10968250-B2
优先权日:2016-05-18
标 题:Intermediates for the synthesis of bile acid derivatives, in particular of obeticholic acid
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
合成参考文献
摘要:Zhang, L., Science of Synthesis: Metal-Catalyzed Cyclization Reactions, (2016) 1, 264.
📝 需求与反馈
尽可能描述清楚需求与问题信息
