CAS: 381-72-6; 2,2-Difluoroacetyl Chloride

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CAS号381-73-7 二氟乙酸 | CAS号425-88-7 1,1,2,2-四氟乙基甲醚 | CAS号2925-22-6 2,2-difluoroace... | CAS号512-51-6 1,1,2,2-四氟乙基乙基醚 | CAS号115611-57-9 1,1,2,2-四氟乙基苄醚 | CAS号98-88-4 苯甲酰氯 | CAS号1648-30-2 2-fluorosulfony... | CAS号7664-93-9 硫酸 | CAS号7789-21-1 氟磺酸 | CAS号7790-94-5 氯磺酸 | CAS号395-01-7 2,2-二氟苯乙酮 | CAS号359-13-7 2,2-二氟乙醇 | CAS号27074-57-3 Morpholine, 4-(... | CAS号114829-07-1 Ethanone, 2,2-d... | CAS号2925-22-6 2,2-difluoroace... | CAS号667-50-5 2,2-difluoro-N,... | CAS号431-71-0 五氟丙酮

📜二氟乙酸置于五氯化磷体系中,用62%的收率获得2,2-二氟乙酰氯
参考文献:该原位某些氟-取代的烯酮的生成和捕集
标题:该原位某些氟-取代的烯酮的生成和捕集
摘要:经由各自的酰氯的脱卤化氢,分别原位产生氟代烯,二氟代烯,甲基氟代烯,三氟甲基氟代烯和苯基氟代烯.在存在环戊二烯的情况下,除了二氟乙烯烯外,均获得了[2 + 2]加合物.在不存在环戊二烯的情况下,低温19 F NMR指示存在烯酮的潜在前体酰基铵盐和烯醇化物,但无法明确检测到实际的烯酮物种.立体化学结果与目前公认的基于乙烯的环烯加成中立体化学测定的基于机理的机理基本一致.
Doi:10.1016/s0040-4020(01)96116-2

专利信息

专利号:US-8629288-B2
优先权日:2008-02-25
标题:Method for the regioselective synthesis of 1-alky1-3-haloalkyl-pyrazole-4-carboxylic acid derivatives
发明人：PAZENOK SERGII; LUI NORBERT; HEINRICH JENS-DIETMAR; WOLLNER THOMAS
权利人:PAZENOK SERGII; LUI NORBERT; HEINRICH JENS-DIETMAR; WOLLNER THOMAS; BAYER IP GMBH
摘要:The present invention relates to a process for the regioselective synthesis of 1-alkyl-3-halo-alkylpyrazole-4-carboxylic acid derivatives by cyclization of 2,3-disubstituted acrylic acid derivatives, and to the hydrazones formed as intermediates in the process.

专利号:US-12134603-B2
优先权日:2022-08-24
标 题:Synthesis method for N-methyl-3-substituted methyl-4-pyrazolamide derivative and N-methyl-3-substituted methyl-4-pyrazolic acid
发明人：LIU SHENGXUE; SHI YINTAO; GONG QIANG; Zhong Sufang; ZHANG JIANJIANG; QIAN XIAOYUAN; GUO FANG; CHEN RUJUN; JIAN XIAOYING
权利人:SHAOXING SHANGYU XIN YINBANG BIOCHEMICAL CO LTD
摘要:The present application relates to a synthesis method for N-methyl-3-substituted methyl-4-pyrazolamide derivative and N-methyl-3-substituted methyl-4-pyrazolic acid, including the following steps: step S1: synthesis of intermediate E; step S2: synthesis of intermediate D; step S3: synthesis of intermediate C; step S4: synthesis of N-methyl-3-substituted methyl-4-pyrazolamide derivative; and synthesis of N-methyl-3-substituted methyl-4-pyrazolic acid by decomposition of N-methyl-3-substituted methyl-4-pyrazolamide derivative.

专利号:US-7884128-B2
优先权日:2005-10-13
标题:Process for total synthesis of pladienolide B and pladienolide D
发明人：KANADA REGINA MIKIE; ITO DAISUKE; SAKAI TAKASHI; ASAI NAOKI; KOTAKE YOSHIHIKO; NIIJIMA JUN
权利人:EISAI R&D MAN CO LTD
摘要:Process for producing compound of Formula: n nwherein P 2 , P 3 and R 2 are the same as defined below, characterized by comprising reacting a compound represented by Formula (7):n n nwherein P 3 means a protecting group for hydroxy group; and Het means a 1-phenyl-1H-tetrazol-5-yl group, with a compound represented by Formula (8):n n nwherein P 2 means a protecting group for hydroxy group; and R 2 means a phenyl group which may be substituted, in the presence of a base.

专利号:US-2008021226-A1
优先权日:2005-10-13
标题:Process for total synthesis of pladienolide B and pladienolide D

专利号:CA-2716381-C
优先权日:2008-02-25
标 题 :Method for the regioselective synthesis of 1-alkyl-3-haloalkyl-pyroazole-4-carboxylic acid derivatives

专利号:US-2010204490-A1
优先权日:2005-10-13
标题 :Process for total synthesis of pladienolide b and pladienolide d