CAS: 343372-29-2; 1,7,13-Trithia-4,10-Diazacyclohexadecan-15-Ol

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2-hydroxymethyl-7,14-diaza-1,4,10-trithiacyclopentadecane sulfidebis2-(α-chloroacetamido)ethyl sulfide 3-hydroxymethyl-7,13-diaza-1,4,10-trithiacyclopentadecane-6,14-dione

📜Bis<2-(α-Chloroacetamido)Ethyl> Sulfide置于盐酸,硼烷四氢呋喃络合物,Potassium Carbonate体系中,用 四氢呋喃,乙腈 用作溶剂,化学反应 124.0H,反应生成1,7,13-三硫杂-4,10-二氮杂环十六碳-15-醇
参考文献:Bis-8-Hydroxyquinoline-Armed Diazatrithia-15-Crown-5 And Diazatrithia-16-Crown-5 Ligands: Possible Fluorophoric Metal Ion Sensors
标题:Bis-8-Hydroxyquinoline-Armed Diazatrithia-15-Crown-5 And Diazatrithia-16-Crown-5 Ligands: Possible Fluorophoric Metal Ion Sensors
摘要:The Synthesis And Preliminary Photophysical Properties Of A Series Of Diazatrithia-15-Crown-5 And Diazatrithia-16-Crown-5 Ligands Containing Two 8-Hydroxyquinoline Sidearms Are Reported. The Ligands Were Prepared By A Two-Step Process. First,Diazatrithiacrown Ethers 11 And 12 Were Prepared By Treating Bis(Alpha-Chloroamide)5 With Various Dimercaptans Followed By Reduction Using A Boron-Thf Complex. Hydroxymethyl-Substituted Macrocycle 12 Was Rearranged To Hydroxysubstituted Diazatrithia-16-Crown-5 In Refluxing Aqueous Hcl. Macrocyclic Diamines 11-13 Were Converted To Either 5-Chloro-8-Hydroxyquinolin-7-Ylmethyl-Sudstituted Diazatrithiacrown Ethers 14-16 By A Mannich Aminomethylation Reaction Or To 8-Hydroxyquinolin-2-Ylmethyl-Substituted Diazatrithiacrown Ethers 17-19 By Reductive Amination Using 8-Hydroxyquinoline-2-Carboxaldehyde. Preliminary Photophysical Studies Show That Ligands 16 And 19 Exhibit Increased Fluorescence In The Presence Of Zn2+,Indicating That These Ligands Could Be Chemical Sensors For Zn2+.
Doi:10.1021/jo0017584