CAS: 284462-37-9; 4-(4-Aminophenoxy)-N-Methylpicolinamide

上下游产品

4-(3-氨基苯氧基)-N-甲基-2-吡啶羧胺 4-(3-Aminophenoxy)-N-Methylpicolinamide 284462-78-8
索拉菲尼杂质hc121-201811 4-(4-Nitro)Benzyloxy-2-Carbonylmethylaminopyridine 864272-34-4
索拉非尼 Sorafenib 284461-73-0
4-(4-氨基苯氧基)吡啶甲酸 4-(4-Aminophenoxy)-2-Pyridine Carboxylic Acid 1012058-77-3
N-甲基吡啶甲酰胺 N-Methylpyridine-2-Carboxamide 6144-78-1

N-甲基吡啶甲酰胺置于硫酸,Palladium 10% On Activated Carbon,氢气,Fluorine,Caesium Carbonate体系中,用 甲醇,N,N-二甲基甲酰胺 用作溶剂,25.0~80.0 °C,275.8 Kpa 条件下,反应 5.0H,反应生成4-(4-氨基苯氧基)-N-甲基-2-吡啶甲酰胺
参考文献:一种甲苯磺酸索拉非尼相关中间体的制备方 法
标题:一种甲苯磺酸索拉非尼相关中间体的制备方 法
摘要:本发明公开了一种甲苯磺酸索拉非尼相关中间体的制备方法,属于医药技术领域.本发明先由‑cooh生成‑conhch3,之后常温下在吡啶环上接上卤素原子合成化合物3,能耗降低.并且本发明后处理简单,易操作,处理后的每一步产物纯度都能达到95%,可直接用于下一步,适合工业化生产.

专利信息

专利号:US-2009253913-A1
优先权日:2008-03-06
标题:Process for the preparation of sorafenib and salts thereof
发明人：ROSSETTO PIERLUIGI; MACDONALD PETER LINDSAY; CANAVESI AUGUSTO
权利人:ROSSETTO PIERLUIGI; MACDONALD PETER LINDSAY; CANAVESI AUGUSTO
摘要:Methods for the synthesis of the N-carbamoyl imidazole (I) and its 1:1 adduct with imidazole are provided. Methods for the preparation of these crystalline intermediates in a high state of purity are also provided. These intermediates react cleanly under mild conditions to produce sorafenib in high yield and purity, without generating difficult-to-remove impurities.