CAS: 26048-05-5; (3S,6R,9S,12R,15S,18R)-3,9,15-Tribenzyl-6,12,18-Triisopropyl-4,10,16-Trimethyl-1,7,13-Trioxa-4,10,16-Triazacyclooctadecane-2,5,8,11,14,17-Hexaone

上下游产品

(R)-2-Hydroxy-3-methylbutyric acid D-Val-OH benzyl (R)-2-hydroxy-3-methylbutanoate45H57N3O9*Na(1+)C45H57N3O9*Na(1+)

📜D-缬氨酸置于盐酸,4-二甲氨基吡啶,1-氯-N,N,2-三甲基丙烯胺,硫酸,Palladium 10% On Activated Carbon,氢气,Caesium Carbonate,盐酸-N-乙基-N'-(3-二甲氨基丙基)碳二亚胺,N,N-二异丙基乙胺,Sodium Nitrite体系中,用 四氢呋喃,1,4-二氧六环,二氯甲烷,水,N,N-二甲基甲酰胺 用作溶剂,60.0 °C,689.49 Kpa 条件下,反应 67.5H,反应生成白僵菌素
参考文献:流动化学合成天然和非天然环寡聚二肽
标题:流动化学合成天然和非天然环寡聚二肽
摘要:流动化学已成功地整合到一系列具有三种不同环尺寸的环寡聚二肽中,包括天然产物双曲霉素(1A),巴辛诺利德(2B)和烯属丙稀酸(1B).建立了可靠的流动化学方案,用于偶联和大环化以形成具有挑战性的n-甲基化酰胺.这种灵活的方法允许以高产率快速合成天然和非天然二肽肽,从而能够进一步探索其有前途的生物活性.
Doi:10.1002/chem.201504457

专利信息

专利号:US-5662898-A
优先权日:1990-08-20
标 题 :Genes for the synthesis of antipathogenic substances
发明人：LIGON JAMES M; HILL DWIGHT STEVEN; LAM STEPHEN TING; HAMMER PHILIP E
权利人:CIBA GEIGY CORP
摘要:The present invention is directed to the production of an antipathogenic substance (APS) in a host via recombinant expression of the polypeptides needed to biologically synthesize the APS. Genes encoding polypeptides necessary to produce particular antipathogenic substances are provided, along with methods for identifying and isolating genes needed to recombinantly biosynthesize any desired APS. The cloned genes may be transformed and expressed in a desired host organisms to produce the APS according to the invention for a variety of purposes, including protecting the host from a pathogen, developing the host as a biocontrol agent, and producing large, uniform amounts of the APS.

专利号:US-9989489-B2
优先权日:2006-12-14
标 题 :Methods for calibrating an array of chemically-sensitive sensors
发明人：ROTHBERG JONATHAN; HINZ WOLFGANG; JOHNSON Kim; BUSTILLO JAMES
权利人:LIFE TECHNOLOGIES CORP; LIFE TECHNNOLOGIES CORP
摘要:Methods and apparatus relating to very large scale FET arrays for analyte measurements. ChemFET (e.g., ISFET) arrays may be fabricated using conventional CMOS processing techniques based on improved FET pixel and array designs that increase measurement sensitivity and accuracy, and at the same time facilitate significantly small pixel sizes and dense arrays. Improved array control techniques provide for rapid data acquisition from large and dense arrays. Such arrays may be employed to detect a presence and/or concentration changes of various analyte types in a wide variety of chemical and/or biological processes. In one example, chemFET arrays facilitate DNA sequencing techniques based on monitoring changes in hydrogen ion concentration (pH), changes in other analyte concentration, and/or binding events associated with chemical processes relating to DNA synthesis.

专利号:US-5817502-A
优先权日:1994-06-08
标题 :Genes for the synthesis of pyrrolnitrin

专利号:US-11213031-B2
优先权日:2017-11-13
标 题:Tetrazolylpropyl derivatives and their use as fungicides
发明人：SUDAU ALEXANDER; HOFFMANN SEBASTIAN; DAHMEN PETER; WEBSTER ROBERT ALAN; MEISSNER RUTH; GOERTZ ANDREAS; MILLER RICARDA; COQUERON PIERRE-YVES; BERNIER DAVID; NICOLAS LIONEL; BRUNET STEPHANE; KENNEL PHILIPPE; TOQUIN VALERIE; GOURGUES MATHIEU; LOQUE DOMINIQUE; THOMAS VINCENT
权利人:BAYER AG; BAYER CROPSCIENCE AG
摘要:The present invention relates to tetrazolylpropyl derivatives of formula (I) n nwherein one of V 1 and V 2 represents CR 3 and the other one of V 1 and V 2 represents N, Q represents a 6-membered aromatic cycle as defined in the specification, and R 1 , R 2 , R 3 , R 4 , and R 5 are defined as disclosed in the specification, to compositions comprising such compounds, to the use of said compounds as fungicides, as well as to particular intermediates useful in the synthesis of said tetrazolylpropyl derivatives.

专利号:US-5639949-A
优先权日:1990-08-20
标 题 :Genes for the synthesis of antipathogenic substances

专利号:WO-2016156284-A1
优先权日:2015-04-02
标 题 :Novel pyridine compounds for controlling phytopathogenic harmful fungi
发明人：NISING CARL FRIEDRICH; BENTING JÃœRGEN; DAHMEN PETER; WACHENDORFF-NEUMANN ULRIKE; MILLER RICARDA; COQUERON PIERRE-YVES; BERNIER DAVID; VORS JEAN-PIERRE; WITTROCK SVEN; KENNEL PHILIPPE; GENIX PIERRE; TSUCHIYA TOMOKI; NAUD SÉBASTIEN; MEISSNER RUTH
权利人:BAYER CROPSCIENCE AG
摘要:The present invention relates to a novel pyridine compound and its salts and N-oxides, a composition comprising such compound, a method for curatively or preventively controlling phytopathogenic harmful fungi of plants or crops comprising the step of applying such compound or composition, to the use of such compound or such composition to control phytopathogenic harmful fungi and to a seed that has been treated with such a compound or such a composition. Further the present invention relates to novel intermediate in the synthesis of the pyridine compounds of the invention.