CAS: 17680-55-6; 7-Bromo-1,2,3,4-Tetrahydroisoquinoline

相似化合物

220247-73-4 258515-65-0 226942-29-6

上下游产品

1,2,3,4-Tetrahydro-isoquinolin-7-ylamine 1-(7-bromo-3,4-dihydroisoquinolin-2(1H)-yl)-2,2,2-trifluoroethan-1-one 2,5-dibromobenzoic acid 5-Bromo-2-carboxymethyl-benzoic acid 7-bromo-N-triphenylmethyl-1,2,3,4-tetrahydroisoquinoline 1-(benzyloxy)-4-(7-bromo-3,4-dihydroisoquinolin-2(1H)-yl)-1,8-naphthyridin-2(1H)-one 7-methanesulfonyl-1,2,3,4-tetrahydro-isoquinoline 7-methylsulfonyl-N-triphenylmethyl-1,2,3,4-tetrahydroisoquinoline

2,5-二溴苯甲酸置于sodium Hydroxide,Sodium Tetrahydroborate,三氟化硼乙醚,氨,Sodium Methylate,三乙胺,Copper(I) Bromide体系中,用 四氢呋喃,甲醇,二氯甲烷,水,乙酸乙酯 用作溶剂,-78.0~70.0 °C,827.37 Kpa 条件下,反应 109.5H,反应生成7-溴-1,2,3,4-四氢异喹啉
参考文献:Synthesis Of 1,2,3,4-Tetrahydroisoquinolines Containing Electron-Withdrawing Groups
标题:Synthesis Of 1,2,3,4-Tetrahydroisoquinolines Containing Electron-Withdrawing Groups
摘要:
Doi:10.1021/jo972184E

专利信息

专利号:US-8933018-B2
优先权日:2011-02-07
标题 :Boron containing polybasic bacterial efflux pump inhibitors and therapeutic uses thereof
发明人：GLINKA TOMASZ; HIGUCHI ROBERT; HECKER SCOTT; EASTMAN BRIAN; RODNY OLGA
权利人:GLINKA TOMASZ; HIGUCHI ROBERT; HECKER SCOTT; EASTMAN BRIAN; RODNY OLGA; REMPEX PHARMACEUTICALS INC
摘要:Disclosed herein are polybasic bacterial efflux pump inhibitors containing boronic acid functionality and their methods of synthesis, methods of use, and pharmaceutical compositions. Some embodiments include methods of treating or preventing a bacterial infection by co-administering to a subject infected with bacteria or at risk of infection with bacteria the efflux pump inhibitor with another anti-bacterial agent.