CAS: 1572-95-8; (2R)-1-Phenylpropan-2-Ol
该化合物是一种有机化合物,其特征是其手性结构,包括附属于二次酒精的一组苯基;该化合物一般是无色的,可粉黄的,具有典型的气味;可溶于乙醇和乙醚等有机溶剂,但由于其氢恐惧性苯基组,在水中溶解性有限;氢氧基(-OH)功能组的存在具有类似酒精的特性,使它成为各种化学反应,包括氧化和酯化的潜在候选物;该特性允许存在对应物,可以展示不同的生物活动,在药物应用中产生(R)-1-Phenyl-2-Propanol的兴趣;此外,它可以作为有机合成的建筑块,特别是在生产更复杂的分子方面;安全数据表明,与许多有机溶剂一样,处理时应当谨慎,避免吸入或皮肤接触.
- 英文名称(2R)-1-Phenylpropan-2-Ol
- 中文名称(R)-1-苯基-2-丙醇
- IUPAC名称(2R)-1-phenylpropan-2-ol
- 其它别名Benzeneethanol,a-methyl-, (R)-; Phenethylalcohol, a-methyl-, (-)- (8CI); (-)-1-Phenyl-2-propanol; (-)-a-Methylbenzeneethanol; (-)-a-Methylphenethyl alcohol; (2R)-1-Phenylpropan-2-ol; (R)-(-)-1-Phenyl-2-propanol; (R)-1-Phenyl-2-propanol
- CAS编号1572-95-8
- MFCD编号:MFCD00066455
- EINECS号:674-892-0
- FDA UNII编号:PLW3H4E008
- 分子式:C9H12O分子量:136.19
- 产品CID: 786042
- 产品分类有机原料 → 醇,酚,酚醇类化合物及衍生物
物理性质
MSDS等安全信息
欧盟法规
C&L通报上下游产品
CAS号698-87-3 1-苯基-2-丙醇 | CAS号14212-54-5 1(1R,2R)-(+)-1-... | CAS号103-79-7 苯基丙酮 | CAS号108-86-1 溴苯 | CAS号15448-47-2 (R)-环氧丙烷 | CAS号75-24-1 三甲基铝 | CAS号122-78-1 2-苯基乙醛 | CAS号108-22-5 醋酸异丙烯酯 | CAS号2114-33-2 乙酸1-甲基-2-苯基乙酯 | CAS号23239-35-2 a-甲基-L-苯丙氨酸 | CAS号103-79-7 苯基丙酮 | CAS号1517-68-6 (S)-1-苯基-2-丙醇合成工艺路线路线简述
📜苯基丙酮置于苯硅烷,Myoglobin Da Ketoreductase体系中,用 Aq. Phosphate Buffer,二甲基亚砜 用作溶剂,以94%的收率获得(R)-1-苯基-2-丙醇
参考文献:将肌红蛋白重新利用为非生物不对称酮还原酶
标题:将肌红蛋白重新利用为非生物不对称酮还原酶
摘要:由于酶再利用的最新进展,血红素蛋白作为多功能生物催化剂而受到广泛关注,其催化从氧化到氧化还原中性反应的各种转化.为了补充这些成就,我们在此报告了我们使用 Phsih 3作为还原剂将肌红蛋白 (Mb) 重新利用为不对称酮还原酶的努力.两轮诱变提供了双突变体,能够在全细胞存在的情况下以高对映选择性减少广泛的前手性脂肪族和芳香族酮.另外几轮定向进化提供了具有相反对映选择性的五重突变体.机理研究表明,短暂的 Fe-H 物质经历异解氢化物转移,从相应的酮中提供对映体纯醇.优异的饱和动力学曲线,结合有氧条件下全细胞生物催化的实用性,凸显了重新利用的 Mb 作为具有广泛底物范围的不对称酮还原酶的潜力,从而扩展了血红素蛋白催化的反应库.
Doi:10.1016/j.Chempr.2024.06.010
海关参考信息
- 2902600000-乙苯
2905122000-异丙醇 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-7750135-B2
优先权日:2006-07-28
标题:Molecular design of thermostable alcohol dehydrogenase for synthesis for chiral aromatic alcohols
发明人：ZEIKUS J GREGORY; ZIEGELMANN-FJELD KARLA I; VIEILLE CLAIRE
权利人:UNIV MICHIGAN STATE
摘要:The present invention relates to compositions and methods utilizing thermostable and novel alcohol dehydrogenase enzymes for biosynthesizing chiral specific molecules for use as precursor molecules in synthesizing pharmaceutical compounds. Particularly, in preferred embodiments, the invention relates to directed engineering of an enzymatic catalytic site of an alcohol dehydrogenase enzyme gene for enhancing enantioselectivity for (S)-enantiomer substrate catalytic activity for providing aryl (S)-enantiomer products in stereomeric excess.
专利号:WO-2014202816-A1
优先权日:2013-06-21
标 题 :Method for the enantioselective synthesis of chiral esters, product obtained and use
专利号:ES-2527260-A1
优先权日:2013-06-21
标 题:PROCEDURE OF ELANTIOS ELANTIOS SYNTHESIS OF CHIRAL ESTERS, PRODUCT OBTAINED AND USE
专利号:ES-2527260-B1
优先权日:2013-06-21
标 题:PROCEDURE OF ELANTIOS ELANTIOS SYNTHESIS OF CHIRAL ESTERS, PRODUCT OBTAINED AND USE
专利号:US-7229817-B2
优先权日:2000-12-12
标题 :Recombinant porcine liver esterases, their use and a method for the production thereof
发明人：BORNSCHEUER UWE; MUSIDLOWSKA ANNA; SCHMIDT-DANNERT CLAUDIA; LANGE STEFAN
权利人:DEGUSSA
摘要:The invention relates to biotechnologically expressible, enzymically active recombinant porcine liver esterases, to a biotechnological method for the preparation thereof and to the use thereof in organic synthesis. The monomeric subunits of recombinant porcine liver esterase are truncated at their C-terminal end, compared with naturally occurring porcine liver esterase subunits. Moreover, it has proved to be an additional advantage to truncate the N-terminal end as well.
专利号:US-2008220487-A1
优先权日:2006-07-28
标题:Molecular design of thermostable alcohol dehydrogenase for synthesis for chiral aromatic alcohols
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
合成参考文献
摘要:Tchabanenko, K., Science of Synthesis Knowledge Updates, (2013) 1, 70.
摘要:Stoltz, B.; Ebner, D. C.; Park, N., Science of Synthesis: Stereoselective Synthesis, (2011) 2, 218.
摘要:de Figueiredo, R. M., Science of Synthesis: Knowledge Updates, (2024) 2, 265.
📝 需求与反馈
尽可能描述清楚需求与问题信息
