CAS: 153505-39-6; 3,4-Difluorobenzene-1,2-Diamine

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上下游产品

2-amino-3,4-difluoronitro-benzene tert-butyl 2-(2-amino-3,4-difluorophenylamino)-2-oxoethylcarbamate tert-butyl 2-(6-amino-2,3-difluorophenylamino)-2-oxoethylcarbamate 2-chloro-N-((4,5-difluoro-1H-benzo[d]imidazol-2-yl)methyl)-9-(3-fluorophenyl)-9H-purin-6-amine

2,3-二氟-6-硝基苯胺置于sodium Tetrahydroborate,Tin(Ll) Chloride体系中,用 乙醇,乙酸乙酯 用作溶剂,化学反应生成2,3-二氟-6-硝基苯胺
参考文献:Sar156497,极光激酶的选择性选择性抑制剂
标题:Sar156497,极光激酶的选择性选择性抑制剂
摘要:丝氨酸/苏氨酸激酶的aurora家族对于有丝分裂必不可少.已经证明了它们在广泛的恶性肿瘤中的细胞周期调控和异常表达中的关键作用,并促使人们对小分子aurora抑制剂进行深入研究.实际上,其中超过10种已作为潜在的抗癌疗法进入临床.我们在此报告了一系列新的三环分子的发现和优化,这些分子导致了sar156497,一种具有体外和体内功效的选择性选择性极光a,B和c抑制剂.我们还提供了有关其与靶蛋白结合模式的见解,这可以解释其选择性.
Doi:10.1021/jm501326K

专利信息

专利号:CN-110790713-B
优先权日:2018-08-02
标题:Regioselective one-step process for the synthesis of 2-hydroxyquinoxaline

专利号:CN-110790713-A
优先权日:2018-08-02
标题 :Regioselective one-step process for the synthesis of 2-hydroxyquinoxaline

专利号:US-7541367-B2
优先权日:2005-05-31
标 题 :3-benzoimidazolyl-pyrazolopyridines useful in treating kinase disorders
发明人：CHIU GEORGE; CONNOLLY PETER J; EMANUEL STUART; HUANG SHENLIN; LI SHENGJIAN; LIN RONGHUI; LU YANHUA; MIDDLETON STEVEN A
权利人:JANSSEN PHARMACEUTICA NV
摘要:The present invention is directed to novel 3-benzoimidazolyl-pyrazolopyridine compounds of formula (I): n nand pharmaceutically acceptable forms thereof and their synthesis and use as inhibitors of serine-threonine protein kinases and tyrosine protein kinases and interactions thereof.