CAS: 145106-43-0; Tert-Butyl ((1S,2S)-2-Hydroxycyclopentyl)Carbamate

该化合物是一种具有环戊基脊柱和氢氧基组在2号位置上具有氢氧基的甲氨基甲酸酯衍生物,该化合物在有机合成中具有价值,特别是作为采用按立体化学定义的环丙基胺聚滴的受保护中间体,在基本条件下保持稳定,同时允许在酸性条件下有选择地取消保护,使之适合多步骤合成路线.其(1S,2S)配置确保不对称合成的对应选择性,这对制药和农用化学应用至关重要.氢氧基组进一步提高其作为额外功能化处理器的效用,在复杂的分子构造中提供多功能性.

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CAS号24424-99-5 二碳酸二叔丁酯 | CAS号930-45-0 (1S,2S)-2-AMINO...

合成工艺路线路线简述

  • 合成目标产物 (1S,2S)-Trans-N-Boc-2-Aminocyclopentanol 主要起始原料 Di-Tert-Butyl Dicarbonate And (1S,2S)-Trans-2-Aminocyclopentanol Hydrochloride
  • (文献来源)合成步骤主要原料 Di-Tert-Butyl Dicarbonate 和 (1S,2S)-Trans-2-Aminocyclopentanol Hydrochloride
📜(1S,2S)-Trans-2-Azidocyclopentanol置于platinum(Iv) Oxide 氢气体系中,化学反应生成(1S,2S)-反式-N-Boc-2-氨基环戊醇
参考文献:Cis-Cyclopentyl Pna (Cppna) As Constrained Chiral Pna Analogues: Stereochemical Dependence Of Dna/rna Hybridizationelectronic Supplementary Information (Esi) Available: Experimental Procedures For The Synthesis Of Compounds,1H,13C NMR,Mass Spectral Data,Crystal Structural Data And Melting Curves For Triplexes. See Http://www.Rsc.Orgpdata/cc/b3/b317000D/
标题:Cis-Cyclopentyl Pna (Cppna) As Constrained Chiral Pna Analogues: Stereochemical Dependence Of Dna/rna Hybridizationelectronic Supplementary Information (Esi) Available: Experimental Procedures For The Synthesis Of Compounds,1H,13C NMR,Mass Spectral Data,Crystal Structural Data And Melting Curves For Triplexes. See Http://www.Rsc.Orgpdata/cc/b3/b317000D/
摘要:对具有cis-(1S,2R/1R,2S)-环戊基单元的pna-T寡聚物进行的dna/rna杂交研究表明,结合具有立体化学依赖性,并且能够区分rna和dna.
Doi:10.1039/b317000D

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专利信息


专利号:US-8129411-B2
优先权日:2005-12-30
标题:Organic compounds
发明人:EHARA TAKERU; GROSCHE PHILIPP; IRIE OSAMU; IWAKI YUKI; KANAZAWA TAKANORI; KAWAKAMI SHIMPEI; KONISHI KAZUHIDE; MOGI MUNETO; SUZUKI MASAKI; YOKOKAWA FUMIAKI
权利人:EHARA TAKERU; GROSCHE PHILIPP; IRIE OSAMU; IWAKI YUKI; KANAZAWA TAKANORI; KAWAKAMI SHIMPEI; KONISHI KAZUHIDE; MOGI MUNETO; SUZUKI MASAKI; YOKOKAWA FUMIAKI; NOVARTIS AG
摘要:The invention relates to 3,5-substituted piperidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on activity of renin; the use of a compound of that class in the treatment of a disease that depends on activity of renin; pharmaceutical formulations comprising a 3,5-substituted piperidine compound, and/or a method of treatment comprising administering a 3,5-substituted piperidine compound, a method for the manufacture of a 3,5-substituted piperidine compound, and novel intermediates and partial steps for its synthesis. n The compounds have the formula I′ n nwherein R1, R2, T, R3 and R4 are as defined in the specification.

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合成参考文献


参考文献:10.1055/s-2008-1032149
摘要:Hawthorne M, Page M, Jalisatgi S, Maderna A. Design and Synthesis of a Candidate α-Human Thrombin Irreversible Inhibitor Containing a Hydrophobic Carborane Pharmacophore. Synthesis. 2008 Feb;2008(4):555–63. doi: 10.1055/s-2008-1032149.
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