CAS: 127062-22-0; Sulfosuccinimidyl-6-(Biotinamido)Hexanoate (Sodium)

相似化合物

127062-22-0 127634-19-9 215312-86-0

专利信息

专利号:US-11987830-B2
优先权日:2019-01-24
标 题 :Cell-free protein synthesis systems
发明人：WATKINS NICHOLAS N; BEER NEIL REGINALD; TURTELTAUB KENNETH W
权利人:L LIVERMORE NAT SECURITY LLC
摘要:Provided herein are cell free protein synthesis (CFPS) systems comprising a plurality of ribosomes attached to or encapsulated within a structure, or a plurality of structures, and, optionally, a solid support. Also provided are related kits and uses of the CFPS systems. Methods of producing a protein and methods of treating a disease are provided herein.

专利号:US-2007048774-A1
优先权日:1998-05-08
标题 :Continuous in-vitro evolution
发明人：COIA GREGORY; HUDSON PETER J; ILIADES PETER; IRVING ROBERT A
权利人:DIATECH PTY LTD
摘要:Provided is a method for the mutation, synthesis and selection of a protein of interest, by first incubating a replicable RNA molecule encoding the protein with ribonucleoside triphosphate precursors of RNA and an RNA-directed RNA polymerase, such that the RNA-directed RNA polymerase replicates the RNA molecule but introduces mutations thereby generating a population of mutant RNA molecules. The mutant RNA molecules are then incubated with a translation system under conditions which result in the synthesis of a population of mutant proteins. After translation, the mutant proteins are linked to their encoding RNA molecules, and one or more mutant proteins of interest are selected.

专利号:US-6562622-B1
优先权日:1998-05-08
标 题:Continuous in vitro evolution
发明人：COIA GREGORY; HUDSON PETER JOHN; ILIADES PETER; IRVING ROBERT ALEXANDER
权利人:DIATECH PTY LTD
摘要:The present invention provides a method for the mutation, synthesis and selection of a protein which binds to a target molecule, the method comprising: (a) incubating a replicable mRNA molecule encoding the protein with ribonucleoside triphosphate precursors of RNA and an RNA-directed RNA polymerase, wherein the RNA-directed RNA polymerase replicates the mRNA molecule but introduces mutations thereby generating a population of mutant mRNA molecules; (b) incubating the mutant mRNA molecules from step (a) with a translation system under conditions which results in the synthesis of population of mutant proteins such that after translation, mutant proteins are linked to their encoding mRNA molecules thereby forming a population of mutant proteins such that after translation, mutant proteins are linked to their encoding mRNA molecules thereby forming a population of mutant/mRNA complexes; (c) selecting one or more mutant protein/mRNA complex(es) by exposing the population of mutant protein/mRNA complexes from step (b) to the target molecule and recovering the mutant protein/mRNA complex(es) bound thereto.

专利号:US-2015250827-A1
优先权日:2011-07-05
标题:Bio-mimetic ultrathin hydrogel coatings for pancreatic islet transplantation
发明人：KHARLAMPIEVA EUGENIA P; KOZLOVSKAYA VERONIKA; THOMPSON J ANTHONY; CUI WANXING
权利人:UAB RESEARCH FOUNDATION
摘要:The present disclosure provides multifunctional cytoprotective materials applied to coat living cells or aggregates of cells such as, but not limited to, pancreatic islets. The coating utilizes hydrogen-bonded interactions of a natural polyphenol (tannic acid) with poly(N-vinylpyrrolidone) deposited on the cell aggregate surface via non-ionic layer-by-layer assembly. The coating is conformal over the surface of such as mammalian islets. The coated islets maintain their viability and cell functionality for at least 96 hours in vitro. The coating demonstrates immunomodulatory cytoprotective properties suppressing pro-inflammatory cytokine synthesis in stimulated bone marrow-derived macrophages and diabetogenic BDC-2.5 T cells. The coating material combines high chemical stability under physiologically relevant conditions with capability of suppressing cytokine synthesis, crucial parameters for prolonged islet integrity, viability, and function in vivo.

专利号:US-11977084-B2
优先权日:2015-02-11
标题 :Nervous system-specific transmembrane proteasome complex that modulates neuronal signaling through extracellular signaling via brain activity peptides
发明人：MARGOLIS SETH S; RAMACHANDRAN KAPIL V
权利人:UNIV JOHNS HOPKINS
摘要:The inventors surprisingly found that neural stimulation caused the synthesis and degradation of proteins into peptides which were then secreted into the cell media within minutes of stimulation by a novel neural-specific and membrane bound proteasome (neuronal membrane proteasome or NMP) that is transmembrane in nature. These secreted, activity-induced, proteasomal peptides (SNAPPs) range in size from about 500 Daltons to about 3000 Daltons. Surprisingly none of the peptides appear to be those previously known to have any neuronal function. Moreover, these SNAPPs have stimulatory activity and are heretofore a new class of signaling molecules. Moreover, the NMP appears to play a highly significant role in aspects of neuronal signaling known to be critical for neuronal function. The inventors have gone on to develop all tools to study this novel mechanisms including protocols and practice for generation and purification of SNAPPs as well as a new and specific inhibitor of the NMP allowing for selective control of this process in the nervous system. The present invention provides methods of making and using these SNAPPs for both laboratory and clinical purposes, the screening for molecules which modulate NMP function in vivo and in vitro, and methods for diagnosis of NMP related diseases.

专利号:US-7579356-B2
优先权日:2005-05-04
标 题:Thia-tetraazaacenaphthylene kinase inhibitors
发明人：BATTISTA KATHLEEN A; BIGNAN GILLES C; CONNOLLY PETER J; HAYDEN STUART; JOHNSON SIGMOND G; LIN RONGHUI; PANDEY NIRANJAN B; POWELL MARK T
权利人:JANSSEN PHARMACEUTICA NV
摘要:The present invention is directed to novel thia-tetraazaacenaphthylene compounds of Formula (I): n nand pharmaceutically acceptable forms thereof and their synthesis and use as inhibitors of ATP-protein kinase interactions.