Diisopropyl Phosphorochloridite 反应生成三异丙基亚磷酸酯 参考文献:Al'Fonsov,V. A.; Pudovik,D. A.; Musin,R. Z.,Journal Of General Chemistry Of The Ussr,1988,Vol. 58,# 8,P. 1548-1553 标题:Al'Fonsov,V. A.; Pudovik,D. A.; Musin,R. Z.,Journal Of General Chemistry Of The Ussr,1988,Vol. 58,# 8,P. 1548-1553
专利号:US-7102023-B2 优先权日:1999-11-24 标 题:Protecting groups useful in the synthesis of polysaccharides, natural products, and combinatorial libraries 发明人:BUCHWALD STEPHEN L; PLANTE OBADIAH J; SEEBERGER PETER H 权利人:MASSACHUSETTS INST TECHNOLOGY 摘要:One aspect of the present invention relates to optionally substituted halogenated benzyl halides and the like. These compounds are useful as halogenated benzyl ether-based protecting groups for a variety of functional groups. Another aspect of the present invention relates to use of said protecting groups in an orthogonal protecting group strategy for the synthesis of complex molecules that comprise a number of suitable functional groups. Another aspect of the present invention relates to saccharides bearing various arrays of protecting groups of the present invention. Another aspect of the present invention relates to a method of synthesizing an oligosaccharide or glycoconjugate, comprising the steps of: using a saccharide bearing at least one protecting group of the present invention to glycosylate a second molecule to give a product comprising said saccharide; and removing a protecting group of the present invention from said product.
专利号:US-12304922-B1 优先权日:2021-12-09 标题:Low pressure process for synthesis of Pt(PF3)4 involving a soluble intermediate and storage of obtained Pt(PF3)4 发明人:NIKIFOROV GRIGORY; BLASCO NICOLAS 权利人:AIR LIQUIDE 摘要:A method for synthesis of Pt(PF3)4 (CAS #19529-53-4), the method comprising the steps of forming a suspension of a platinum precursor Pt(Hal)2, wherein Hal=F, Cl, Br or I, and a metal powder in a solvent, introducing excess amount of PF3 into the suspension of Pt(Hal)2 and the metal powder, forming a soluble reaction intermediate Pt(Hal)2(PF3)x in the solvent through a reaction between PF3 and Pt(Hal)2, wherein Hal=F, Cl, Br or I, x=1, 2, under a reaction condition, and forming Pt(PF3)4 from a reaction between Pt(Hal)2(PF3)x, the metal powder and the excess of PF3 in the solvent.
专利号:US-5126452-A 优先权日:1990-04-06 标 题 :Synthesis of purine substituted cyclopentene derivatives 发明人:VINCE ROBERT; PETERSON MARK L; LACKEY JOHN W; MOOK JR ROBERT A; PARTRIDGE JOHN J 权利人:GLAXO INC 摘要:This invention relates to new process for preparing certain optically active purine substituted cyclopentene derivatives and novel intermediates used in this process. In particular, the invention concerns the synthesis of the 1R-cis isomer of carbovir, (1R-cis)-amino-1,9-dihydro-9-[4-(hydroxymethyl)-2-cyclopenten-1-yl]-6H-purin-6-one, an antiviral agent, and certain intermediates.
专利号:US-5057630-A 优先权日:1990-04-06 标 题 :Synthesis of cyclopentene derivatives 发明人:LACKEY JOHN W; MOOK JR ROBERT A; PARTRIDGE JOHN J 权利人:GLAXO INC 摘要:This invention relates to a new process for preparing certain optically active purine substituted cyclopentene derivatives including the antiviral agent, carbovir, and novel intermediates used in this process. In particular, this invention concerns a synthesis of (1R-cis)-4-hydroxymethyl-2-cyclopenten-1-ol, an intermediate in this process.
专利号:US-6395894-B2 优先权日:1998-04-16 标 题 :Process for the synthesis of carbapenem intermidiates, and compounds produced 发明人:PYE PHILIP J; REIDER PAUL J; ROSSEN KAI; VOLANTE RALPH P 摘要:A process of synthesizing a compound of structural formula 6is disclosed wherein R1 represents H or a suitable protecting group for an alcohol; R2 represents a benzyl, C1-6 alkyl or aryl; Y represents C1-3 alkyl, O, NH or S; X represents O, NH, or S and R5 represents a carboxy protecting group, comprising reacting a compound of formula 5:wherein R1, R2, R5, X and Y are as previously described with a phosphite or phosphonite reagent to produce a compound of formula 6. Further disclosed is an efficient method for the synthesis of a compound of formula 2:which comprises reacting a 4-acyl-2-azetidinone with a titanium, zirconium or hafnium enolate of a 1-hydroxy-2-butanone derivative.
专利号:US-4782146-A 优先权日:1986-07-29 标题 :Process for the synthesis of penems 发明人:BRIGHTY KATHERINE E 权利人:PFIZER 摘要:A process for the synthesis of penems from azetidinones via 1-aza-4,5-dithiabicyclo[4.2.0]oct-2-en-8-one-2-carboxylate esters.
摘要:Black, D. A.; Fagnou, K., Science of Synthesis, (2010) 45, 555. 摘要:Schramm, M. P., Science of Synthesis, (2009) 46, 495. 摘要:Palframan, M. J.; Parsons, A. F., Science of Synthesis, (2009) 48, 681. 摘要:Spitzner, D., Science of Synthesis Knowledge Updates, (2016) 1, 182. 摘要:Spitzner, D., Science of Synthesis Knowledge Updates, (2016) 1, 84.