十六胺置于乙醇,Petroleum Ether体系中,化学反应生成十六烷基三甲基氯化铵 参考文献:Ralston Et Al.,Journal Of The American Chemical Society,1947,Vol. 69,P. 2096 标题:Ralston Et Al.,Journal Of The American Chemical Society,1947,Vol. 69,P. 2096
专利号:US-12383499-B2 优先权日:2018-01-01 标题:Scale up synthesis of silicasome nanocarriers 发明人:NEL ANDRE E; MENG HUAN; LIU XIANGSHENG 权利人:UNIV CALIFORNIA 摘要:In order to facilitate the approval and commercialization of silicasome drug delivery systems (e.g. irinotecan silicasomes) it is necessary to scale up synthesis of the drug-loaded silicasomes. In this regard, it was discovered that the synthesis protocols used for laboratory synthesis of drug-loaded silicasomes (e.g., 500 mg/batch) do not scale to large scale silicasome production, because the resulting products were too heterogeneous for use as pharmaceuticals. Accordingly, new methods are provided herein that effectively afford the large-scale production of mesoporous silica nanoparticles (MSNPs) and lipid bilayer coated MSNPs (silicasomes).
专利号:US-7199257-B1 优先权日:1999-06-10 标题 :Process for the synthesis of N-(4-cyano-3-trifluoromethylphenyl)-3-(4-fluorophenylsulfonyl)-2-hydroxy-2-methylpropionamide 发明人:SOEROES BELA; TUBA ZOLTAN; GALIK GYOERGY; BOR ADAM; DEMETER ADAM; TRISCHLER FERENC; HORVATH JANOS; BRLIK JANOS 权利人:RICHTER GEDEON VEGYESZET 摘要:A new process is disclosed for the synthesis of racemic or optically pure N-[4-cyano-3-trifluoro-methyl-phenyl]-3[4-fluorophenyl-sulfonyl]-2-hydroxy-2-methylpropionamide. The process includes the formation of several novel intermediates in the synthesis.
专利号:US-6540970-B1 优先权日:1999-11-18 标题:Method for the synthesis of molecular sieves 发明人:STROHMAIER KARL G; VAUGHAN DAVID E W 权利人:EXXON MOBIL CHEM PATENTS INC 摘要:The present invention provides a method for the synthesis of MeAPO molecular sieves which includes the following steps: providing a source of alumina, a source of phosphorus, water, and a template suitable for forming a MeAPO molecular sieve; providing a source of metal (Me) including metal particles, the metal particles measuring, in their largest dimension, equal to or less than five nanometers; providing a water soluble organic solvent capable of solubilizing the source of metal; forming a synthesis mixture from the source of alumina, the source of phosphorus, the water, the template, the source of metal, and the solvent; and forming a MeAPO molecular sieve from the synthesis mixture.
专利号:US-2012215002-A1 优先权日:2009-10-09 标 题:Synthesis of optically active intermediate for the preparation of montelukast 发明人:LEFORT LAURENT 权利人:LEFORT LAURENT 摘要:The present invention relates to the synthesis of optically active alcohols by means of enantioselective hydrogenation of ketones in biphasic systems. In particular the present invention relates to the synthesis of an optically active alcohol of general formula (1).
专利号:WO-2024220674-A1 优先权日:2023-04-18 标题:Timescale-guided microfluidic synthesis of polyphenol-iron iii network nanocapsules of hydrophobic drugs 发明人:YEO YOON; HAN BUMSOO; SHEN YINGNAN 权利人:PURDUE RESEARCH FOUNDATION 摘要:A scalable method of continuous microfluidic synthesis of tannic acid-iron III (TA-FeIII) network (TFN) nanocapsules of a hydrophobic drug; a scalable method of continuous microfluidic synthesis of epigallocatechin-3-gallate iron III (EGCG-FeIII) network, (EFN) nanocapsules; hydrophobic drug nanocapsules synthesized in accordance with the method; and a method of administering a hydrophobic drug to a patient in need thereof by administering to the patient the hydrophobic drug nanocapsules.
专利号:US-2008103312-A1 优先权日:2006-08-29 标 题:Processes for the synthesis of 5-phenyl-1-trityl-1H-tetrazole 发明人:KANSAL VINOD K; MISTRY DHIRENKUMAR N; VASOYA SANJAY L; LUNAGARIYA VIJAYKUMAR D 权利人:KANSAL VINOD K; MISTRY DHIRENKUMAR N; VASOYA SANJAY L; LUNAGARIYA VIJAYKUMAR D 摘要:Provided are processes for the synthesis of 5-phenyl-1-trityl-1H-tetrazole, an intermediate useful in the synthesis of irbesartan.
1: van Ginkel CG, van Dijk JB, Kroon AG. Metabolism of hexadecyltrimethylammonium chloride in Pseudomonas strain B1. Appl Environ Microbiol. 1992 Sep;58(9):3083-7. doi: 10.1128/aem.58.9.3083-3087.1992. 2: Darkins R, Sushko ML, Liu J, Duffy DM. The effect of surface topography on the micellisation of hexadecyltrimethylammonium chloride at the silicon-aqueous interface. J Phys Condens Matter. 2015 Feb 11;27(5):054008. doi: 10.1088/0953-8984/27/5/054008. Epub 2014 Dec 22. 652(2):369-376. DOI: 10.1016/0021-9673(93)83255-q. 29(1):73-77. DOI: 10.2116/analsci.29.73.
合成参考文献
摘要:Ouyang, Y.; Shou, J.-Y.; Qing, F.-L., Science of Synthesis: Special Topics, (2022) 1, 260. 摘要:NITTA T ET AL; NIPPON SEIRIGAKU ZASSHI 35 (10): 576 (1973) 摘要:NIOSH; National Occupational Exposure Survey (NOES) (1983) 摘要:Franke C et al; Chemosphere 29: 1501-14 (1994) 摘要:S13 | EUCOSMETICS | Combined Inventory of Ingredients Employed in Cosmetic Products (2000) and Revised Inventory (2006) | DOI:10.5281/zenodo.2624118