CAS: 106820-63-7; Methyl 3-(N-(2-Methoxy-2-Oxoethyl)Sulfamoyl)Thiophene-2-Carboxylate

相似化合物

59337-93-8 70374-37-7 1820607-57-5

上下游产品

CAS号5680-79-5 甘氨酸甲酯盐酸盐 | CAS号59337-92-7 3-(氯磺酰)-2-噻吩羧酸甲酯 | CAS号59337-89-2 3-氯噻吩-2-羧酸 | CAS号59337-91-6 3-chlorosulfony... | CAS号98827-44-2 替诺昔康环合物 | CAS号59804-37-4 替诺昔康 | CAS号59804-25-0 替诺昔康甲化物

3-(Chlorosulfonyl)-2-Thiophenecarbonyl Chloride置于吡啶体系中,用 氯仿 用作溶剂,化学反应 7.0H,反应生成3-磺酰氨基乙酸甲酯-2-噻吩甲酸甲酯
参考文献:Analogs And Derivatives Of Tenoxicam. 1. Synthesis And Antiinflammatory Activities Of Analogs With Different Residues On The Ring Nitrogen And The Amide Nitrogen
标题:Analogs And Derivatives Of Tenoxicam. 1. Synthesis And Antiinflammatory Activities Of Analogs With Different Residues On The Ring Nitrogen And The Amide Nitrogen
摘要:The Synthesis Of Tenoxicam,4-Hydroxy-2-Methyl-N-2-Pyridyl-2H-Thieno[2,3-E]-1,2-Thiazine-3-Carboxami De 1,1-Dioxide (1E),And Of The Analogues With Various Residues On The Ring Nitrogen And The Amide Nitrogen Is Described. This New Class Of "Oxicams" Has Pronounced Antiinflammatory And Analgesic Properties. The Very Specific Structure-Activity Relationship Of Isomeric And Isosteric Groups At The Amide Nitrogen Has Been Evaluated. The Substituent In Position 2 Also Has A Great Influence On The Pharmacological Properties. Tenoxicam Is Presently Undergoing Clinical Trials.
Doi:10.1021/jm00387A017