CAS: 96-21-9; 1,3-Dibromopropan-2-Ol

该化合物是一种有机化合物,其特点是存在两个溴原子和一个与三碳丙烷脊柱相连的氢氧基(-OH)组(-OH),其分子式为C3H6BR2O,其特征为手性中心,使其光学活性.该化合物一般是无色的,可粉黄的黄色液体,有略微甜味;由于氢氧基组,其极分性会增加,在水中溶解.1,3-二溴-2-丙醇主要用于有机合成,特别是作为生产各种药品和农用化学品的一种中间体.它也可以作为化学反应的试剂,如核循环替代.然而,必须小心处理这一化合物,因为它可能构成健康风险,包括皮肤和眼刺激,以及接触的潜在毒性.在实验室环境中与该物质合作时,应注意适当的安全措施.

结构式图片

相似化合物

16088-60-1 35995-55-2 26581-42-0

物理性质

MSDS等安全信息

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

CAS号3132-64-7 环氧溴丙烷 | CAS号35995-55-2 (((1,3-二溴丙烷-2-基... | CAS号106-95-6 烯丙基溴 | CAS号56-81-5 甘油 | CAS号83165-32-6 mono-(+)-2,3-Di... | CAS号10035-10-6 氢溴酸 | CAS号3132-64-7 环氧溴丙烷 | CAS号107-02-8 丙烯醛 | CAS号107-18-6 烯丙醇 | CAS号22910-07-2 1,3-bis(phenyls... | CAS号816-39-7 1,3-二溴丙酮 | CAS号153851-38-8 tert-butyl-(1,3... | CAS号996-67-8 Bromodinitromethane | CAS号79-08-3 溴乙酸 | CAS号96-11-7 1,2,3-三溴丙烷 | CAS号627-15-6 1,3-二溴-1-丙烯

合成工艺路线路线简述

  • 35995-55-2 = 96-21-9
    反应条件:1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Ethanol; 4 H,50 Psi,Rt
    标题:Synthesis Of Cationic Cardiolipin Analogs
    作者:Kasireddy,Krishnudu; Ali,Shoukath M.; Ahmad,Moghis U.; Choudhury,Sreeti; Chien,Pei-Yu; Et Al
    参考文献:Bioorganic Chemistry 日期:2005 卷标:33(5) 页码:345-362]

    = 96-21-9
    反应条件:1.1 Catalysts: Isoniazid Solvents: Tetrahydrofuran; Rt1.2 Reagents: Bromine Solvents: Tetrahydrofuran; 15 Min,Rt; 0.33 H,Rt
    标题:A Facile Conversion Of Epoxides To Halohydrins With Elemental Halogen Using Isonicotinic Hydrazide (Isoniazide) As A New Catalyst
    作者:Sharghi,Hashem; Eskandari,Mohammad Mehdi; Ghavami,Raoof
    参考文献:Journal Of Molecular Catalysis A: Chemical 日期:2004 卷标:215(1-2) 页码:55-62]

    = 96-21-9
    反应条件:1.1 Reagents: Hydrogen Bromide Solvents: Water; 0 °C; 8 H,0 °C1.2 Solvents: Water
    标题:The First Synthesis Of Natural Disulfide Bruguiesulfurol And Biological Evaluation Of Its Derivatives As A Novel Scaffold For Ptp1B Inhibitors
    作者:Chen,Jing; Jiang,Cheng-Shi; Ma,Wen-Quan; Gao,Li-Xin; Gong,Jing-Xu; Et Al
    参考文献:Bioorganic & Medicinal Chemistry Letters 日期:2013 卷标:23(18) 页码:5061-5065]

    121596-79-0 = 96-21-9
    反应条件:1.1 Reagents: Iron Pentacarbonyl Solvents: Acetic Acid
    标题:Carboxy- And Cyano-Hydroxylation Of Alkenes. Synthesis Of 3-Hydroxy-4-Amino Acids And Butyrolactones Via The Isoxazoline Route
    作者:Halling,Karen; Thomsen,Ib; Torssell,Kurt B. G.
    参考文献:Liebigs Annalen Der Chemie 日期:1989 卷标:(10) 页码:985-90]

    = 96-21-9
    反应条件:1.1 Reagents: 2,4,6-Tribromo-1,3,5-Triazine,Morpholine,4-Methyl-,4-Oxide,Hydrate (1:1) Solvents: Chloroform; 10 Min,-10 °C; -10 °C -> Rt1.2 Reagents: Sodium Sulfite; 15 Min,Rt
    标题:Studies Into Reactions Of N-Methylmorpholine-N-Oxide (Nmmo) And Its Hydrates With Cyanuric Chloride
    作者:Rosenau,Thomas; Potthast,Antje; Kosma,Paul
    参考文献:Tetrahedron 日期:2002 卷标:58(49) 页码:9809-9815]

    = 96-21-9
    反应条件:1.1 Reagents: Potassium Bromide; 72 H,50 °C
    标题:Expeditious Syntheses To Pharmochemicals 1,3-Dihydroxyacetone,1,3-Dichloro-,1,3-Dibromo- And 1,3-Diiodoacetone From Glycerol 1,3-Dichlorohydrin Using Homogenous And Heterogenous Medium
    作者:Da Silva,Fernanda Priscila N. R.; Dos Santos,Priscila F.; Da Silva,Sara R. B.; Pereira,Vera Lucia P.
    参考文献:Journal Of The Brazilian Chemical Society 日期:2020 卷标:31(8) 页码:1725-1731]

    = 96-21-9
    反应条件:1.1 Catalysts: Thiourea Solvents: Acetonitrile; Rt1.2 Reagents: Bromine Solvents: Acetonitrile; 0.8 H,Rt
    标题:Conversion Of Epoxides Into Halohydrins With Elemental Halogen Catalyzed By Thiourea
    作者:Sharghi,Hashem; Eskandari,Mohammad Mehdi
    参考文献:Tetrahedron 日期:2003 卷标:59(43) 页码:8509-8514]

    = 96-21-9 [标题:Reaction Conditions
    标题:Biodehalogenation. Pathway For Transhalogenation And The Stereochemistry Of Eposide Formation From Halohydrins
    作者:Bartnicki,E. W.; Castro,C. E.
    参考文献:Biochemistry 日期:1969 卷标:8(12) 页码:4677-80]

    = 96-21-9
    反应条件:1.1 Reagents: Hydrogen Bromide Solvents: Water; 12 H,Rt
    标题:Film Thickness And Insensitive Electron Transport Layer Materials For Organic Solar Cells
    参考文献:China]

    = 96-21-9
    反应条件:1.1 Reagents: Hydrogen Bromide; Rt -> 0 °C; 4 H,0 °C
    标题:Preparation Of Bruguiesulfurol And Its Intermediates
    参考文献:China]

    6746-81-2 = 96-21-9
    反应条件:1.1 Reagents: Cuprate(2-),Tetrabromo-,Dilithium Solvents: Acetonitrile; Reflux
    标题:Glycidyl Tosylate
    作者:Bittman,Robert
    参考文献:E-Eros Encyclopedia Of Reagents For Organic Synthesis 日期:2001 卷标:1 页码:1-3]

    = 96-21-9
    反应条件:1.1 Reagents: Lithium Bromide Solvents: Dichloromethane; 18 H,Rt
    标题:Synthesis Of Di-,Tri-,And Tetrasubstituted Oxetanes By Rhodium-Catalyzed O-H Insertion And C-C Bond-Forming Cyclization
    作者:Davis,Owen A.; Bull,James A.
    参考文献:Angewandte Chemie 日期:2014 卷标:53(51) 页码:14230-14234]

    = 96-21-9
    反应条件:1.1 Reagents: Bromine Catalysts: 2,2′-[oxybis(2,1-Ethanediyloxy)]Bis[benzenamine] Solvents: Dichloromethane; 15 Min,Rt; 2.5 H,Rt
    标题:Halogenated Cleavage Of Epoxides Into Halohydrins In The Presence Of A Series Of Diamine Podands As Catalyst With Elemental Iodine And Bromine
    作者:Sharghi,Hashem; Paziraee,Zahra; Niknam,Khodabakhsh
    参考文献:Bulletin Of The Korean Chemical Society 日期:2002 卷标:23(11) 页码:1611-1615]

    = 96-21-9
    反应条件:1.1 Reagents: Bromine Catalysts: Hydrazine,Phenyl- Solvents: Dichloromethane; 2.5 H,Rt
    标题:Conversion Of Epoxides To Halohydrins With Elemental Halogen Catalyzed By Phenylhydrazine
    作者:Sharghi,Hashem; Eskandari,Mohammad Mehdi
    参考文献:Synthesis 日期:2002 卷标:(11) 页码:1519-1522]

    56-81-5 = 96-21-9
    反应条件:1.1 Reagents: Trifluoroacetic Anhydride Solvents: Tetrahydrofuran1.2 Reagents: Lithium Bromide Solvents: Tetrahydrofuran,Hexamethylphosphoramide
    标题:A New And Efficient One-Pot Preparation Of Alkyl Halides From Alcohols
    作者:Camps,Francisco; Gasol,Vicens; Guerrero,Angel
    参考文献:Synthesis 日期:1987 卷标:(5) 页码:511-12]

    56-81-5 = 96-21-9
    反应条件:1.1 Reagents: Phosphorus,Bromine
    标题:Glycerol α,γ-Dibromohydrin
    作者:Braun,Geza
    参考文献:Organic Syntheses 日期:1934 页码:42-4]

    56-81-5 = 96-21-9 [标题:Reaction Conditions
    标题:Synthesis Of Triglycerides From 1,3-Dibromopropan-2-Ol
    作者:Bhati,Asharam; Hamilton,Richard J.; Steven,David A.; Aneja,Rajender; Padley,Frederick B.
    参考文献:Journal Of The Chemical Society 日期:1983 卷标:(10) 页码:1553-8]

    = 96-21-9
    反应条件:1.1 Reagents: Alumina,Potassium Bromide; 3 D,50 °C
    标题:Green Synthesis Of Glycerol 1,3-Bromo- And Iodohydrins Under Solvent-Free Conditions
    作者:Dos Santos,Priscila Faustino; Da Silva,Sara Raposo Benfica; Da Silva,Fernanda Priscila Nascimento Rodrigues; Costa,Jeronimo Da Silva; Inada,Jane Sayuri; Et Al
    参考文献:Green Chemistry Letters And Reviews 日期:2019 卷标:12(4) 页码:389-394
甘油置于三甲基溴硅烷,溶剂黄146体系中,化学反应 9.0H,以80%的收率获得产物1,3-二溴-2-丙醇
参考文献:溴三甲基硅烷作为溴醇合成的选择性试剂
标题:溴三甲基硅烷作为溴醇合成的选择性试剂
摘要:溴三甲基硅烷 (Tmsbr) 是一种非常有效的试剂,可将甘油无溶剂转化为溴醇,溴醇是精细化学品生产中有用的中间体.由于甘油是生物柴油生产中的相关副产品,Tmsbr 也经过测试作为酸性条件下酯交换反应的介体,以非常好的产率从蓖麻油中提供 Fame,并从甘油中提供溴醇.随后对甘油转化率进行了优化,根据反应条件,甘油可以选择性地转化为 α-一溴丙醇 (1-Mbh) 或 α,γ-二溴丙醇 (1,3-Dbh),收率非常高.
DOI:10.1039/d1Ra01980E

海关参考信息

专利信息


专利号:US-7994346-B2
优先权日:2001-11-06
标题 :Intermediates for the preparation of lipoxin A4 analogs
发明人：GROSSBACH DANJA; GUILFORD WILLIAM; SANDER MICHAEL
权利人:BAYER SCHERING PHARMA AG
摘要:This invention is directed to compounds useful as intermediates in the synthesis of lipoxin A 4 analogs of the following formulas (I) and (II): n nwherein R 1 , R 2 , R 3 , R 4 and R 5 are described herein. These analogs are useful in treating inflammatory and autoimmune disorders in humans. These analogs are also useful in treating pulmonary or respiratory tract inflammation in humans.

专利号:US-4943528-A
优先权日:1988-11-22
标 题 :Process for the production of optically active (R)-(-)-3-halo-1,2-propanediol
发明人：NAKAMURA TETSUJI; WATANABE ICHIRO
权利人:NITTO CHEMICAL INDUSTRY CO LTD
摘要:A process for the production of an optically active (R)-(-)-3-halo-1,2-propanediol which comprises contacting a 1,3-dihalo-2-propanol with a dehalogenase originating from a microorganism belonging to the genus Corynebacterium or Microbacterium. This process makes it possible to produce the (R)-(-)-3-halo-1,2-propanediol, which is highly useful as a starting material in the synthesis of various drugs and physiologically active substances, theoretically at a yield of 100%.

专利号:US-5637757-A
优先权日:1995-04-11
标 题 :One-pot synthesis of ring-brominated benzoate compounds
发明人：HILL JOHN E; FAVSTRITSKY NICOLAI A; MAMUZIC RASTKO I; BHATTACHARYA BHABATOSH
权利人:GREAT LAKES CHEMICAL CORP
摘要:A method of preparing tetrabromobenzoate compounds from tetrabromophthalic anhydride by reacting tetrabromophthalic anhydride with alcohol in the presence of a decarboxylation catalyst. The reaction may be carried out in an excess of alcohol, or with a near stoichiometric amount of alcohol by performing the reaction in an inert solvent.

专利号:US-2009111737-A1
优先权日:1999-05-24
标题:Novel antibacterial agents
发明人：CHRISTENSEN BURTON G; MORAN EDMUND J; GRIFFIN JOHN H; JUDICE J KEVIN; MU YONGQI; PACE JOHN L; MAMMEN MATHAI; AGGEN JAMES
权利人:CHRISTENSEN BURTON G; MORAN EDMUND J; GRIFFIN JOHN H; JUDICE J KEVIN; MU YONGQI; PACE JOHN L; MAMMEN MATHAI; AGGEN JAMES
摘要:This invention relates to novel multibinding compounds (agents) that are antibacterial agents. The multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands in their monovalent (i.e., unlinked) state have the ability to bind to a an enzyme involved in cell wall biosynthesis and metabolism, a precursor used in the synthesis of the bacterial cell wall and/or the bacterial cell surface thereby interfere with the synthesis and/or metabolism of the cell wall. In particular the multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands hasn a ligand domain capable of binding to penicillin binding proteins, a transpeptidase enzyme, a substrate of a transpeptidase enzyme, a beta-lactamase enzyme, pencillinase enzyme, cephalosporinase enzyme, a transglycoslase enzyme, or a transglycosylase enzyme substrate; Preferably, the ligands are selected from the beta lactam or glycopeptide class of antibacterial agents.

专利号:US-8766002-B2
优先权日:2009-11-26
标题:Preparation and purification of iodixanol
发明人：HU ZHIQI; ZHANG HUOYING
权利人:HU ZHIQI; ZHANG HUOYING; IMAX DIAGNOSTIC IMAGING HOLDING LTD
摘要:An improved synthesis method for preparation of iodixanol, and a purification process through macroporous adsorption resin chromatographic column and recrystallization are provided. The synthesis method relates to dimerization of 5-acetamido-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-isophthalamide (compound A) to prepare iodixanol, wherein excessive side reactions such as alkylation are effectively inhibited by controlling the pH of the reaction mixture with a boron-containing acidic substance or salts thereof such as boric acid. In this way, the conversion rate of compound A to iodixanol is 85-90%. The iodixanol crude product is purified by a macroporous adsorption resin chromatographic column, obtaining iodixanol product with recovery of 90-95% and purity of 96-98%. The iodixanol crude product is recrystallized in mixed solvent containing 2-methoxyethanol, obtaining iodixanol product with recovery of 90-95% and purity of greater than 99%.

专利号:US-6307062-B1
优先权日:1997-02-13
标 题:(Thio) (meth) acrylate monomers, intermediate compounds for the synthesis of these monomers, polymerisable compositions and polymers obtained, and their optical and ophthalmic uses

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主要参考文献

[参考文献]: Hemant Joshi, Et Al. Palladium-Phosphorus/sulfur Nanoparticles (Nps) Decorated On Graphene Oxide: Synthesis Using The Same Precursor For Nps And Catalytic Applications In Suzuki-Miyaura Coupling. Nanoscale. 2014 May 7;6(9):4588-97.
[参考文献]: M P Byrne, Et Al. Chemically Crosslinked Protein Dimers: Stability And Denaturation Effects. Protein Sci. 1995 Dec;4(12):2545-58.
[参考文献]: Rudong Shan, Et Al. Syntheses, Calcium Channel Agonist-Antagonist Modulation Activities, And Nitric Oxide Release Studies Of Nitrooxyalkyl 1,4-Dihydro-2,6-Dimethyl-3-Nitro-4-(2,1,3-Benzoxadiazol-4-Yl)Pyridine-5-Carboxylate Racemates, Enantiomers, And Diastereomers. J Med Chem. 2004 Jan 1;47(1):254-61.
[参考文献]: Y Mikata, Et Al. Sugar-Pendant Diamines. J Org Chem. 2001 Jun 1;66(11):3783-9.

合成参考文献


摘要:Arzneimittel-Forschung. Drug Research., 17(145), 1967 []
摘要:Stevenson, P. J., Science of Synthesis, (2007) 31, 1929.
摘要:Block, E., Science of Synthesis, (2008) 39, 1033.
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