CAS: 93951-89-4; Dimethyl Phthalate (Ring-D4)

该化合物是二甲基phethalate的脱化类似物,其中将芳香环上第3,4,5和6号位置的氢原子替换为.这种同位素标签提高了其在质量光谱测量和NMR分析方法中作为内部标准的效用,确保了高精确度分析.除子代用将非标签化合物的干扰降到最低程度,提高了信号分辨率和精确度.其化学稳定性和与普通有机溶剂的兼容性使其适合环境,制药和代谢研究中的痕量检测.这一化合物对于需要强力同位素分解技术的研究特别有用.

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CAS号87976-26-9 酞酸-3,4,5,6-d4 | CAS号18107-18-1 (三甲硅烷)重氮甲烷

合成工艺路线路线简述

  • 87976-26-9 = 93951-89-4
    反应条件:1.1 Reagents: 1-Ethyl-3-(3′-Dimethylaminopropyl)Carbodiimide Hydrochloride Catalysts: 4-(Dimethylamino)Pyridine Solvents: Dichloromethane; 1 H,Rt
    标题:An Efficient And General Method For The Synthesis Of Stable Isotope Deuterium Labeled Phthalate Esters
    作者:Xu,Zhongjie; Zhao,Cheng; Sun,Wen; Lei,Wen; Hu,Zuming
    参考文献:Journal Of Labelled Compounds And Radiopharmaceuticals 日期:2021 卷标:64(10) 页码:378-384
📜氘代邻二甲苯-D10置于4-二甲氨基吡啶,Potassium Permanganate,水,盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺体系中,用 二氯甲烷,异丁醇 作为反应溶剂,化学反应 1.0H,反应生成 邻苯二甲酸二甲酯-3,4,5,6-D4
参考文献:An Efficient And General Method For The Synthesis Of Stable Isotope Deuterium Labeled Phthalate Esters
标题:An Efficient And General Method For The Synthesis Of Stable Isotope Deuterium Labeled Phthalate Esters
摘要:本文介绍了一种高效且通用的合成氘标记邻苯二甲酸酯的方法,该方法使用廉价且易得的氘标记o-二甲苯作为起始材料,实现了高同位素富集度和优异的化学纯度.通过1H NMR和质谱法确认了其结构和同位素丰度.这些氘标记邻苯二甲酸酯可作为分析参考标准,用于检测土壤,水,食品,塑料制品等中的增塑剂残留.
DOI:10.1002/jlcr.3930

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主要参考文献

参考标题:Efficient And Selective Pt/c-Catalyzed H-D Exchange Reaction Of Aromatic Rings
作者:Nobuhiro Ito,Hiroyoshi Esaki,Tsuneaki Maesawa,Eikoh Imamiya,Tomohiro Maegawa,Hironao Sajiki |发布日期:2008.2.15
摘要:An Effective And Applicable Deuteration Method For Aromatic Rings Using Pt/c-D2O-H2 System Was Established. Especially, Phenol Was Fully Deuterated Even At Room Temperature, And Other Electron-Rich Aromatic Nuclei Were Efficiently Deuterated Under Mild Conditions. The Scope And Limitations Of The Presence Method And Its Application To The Synthesis Of Deuterium-Labeled Biologically Active Compounds And Deuterium-Labeled Building Blocks For Practical Multi-Gram Scale Syntheses Are Reported.

合成参考文献


参考文献:10.1007/s11356-024-34600-3
摘要:Chen X, Yu N, Yang N, Zhang J, Chen J. Simultaneous determination of sixteen phthalic acid esters (PAEs) in soil and evaluation of matrix effect using a QuEChERS/GC/MS-internal standard method. Environ Sci Pollut Res Int. 2024 Aug;31(39):51253–66. doi: 10.1007/s11356-024-34600-3.
参考文献:10.1007/s11356-025-37219-0
摘要:Kakavas K, Faraslis I, Awad R, Katsafadou A, Mirmigkou S, Providas E, Giovanoulis G. Assessment of water pollution and environmental impacts in the Pineios river basin before and after extreme flood events in Thessaly, Greece. Environ Sci Pollut Res Int. 2025 Nov;32(51):29113–31.
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