CAS: 89379-73-7; 2-Oxo-3H-Pyrimidine-4-Carboxylic Acid

该化合物是一种环状七环有机化合物,其特征是其火水环结构,其特点是碳基组(酮)和碳酸功能组;该化合物通常具有如室温固体等特性,由于碳酸组的存在,极地溶剂中可能有溶解性;它可能参与各种化学反应,包括凝聚和循环化,使其对合成有机化学产生兴趣;红心和碳酸的功能都表明在形成衍生物或进一步转化中具有潜在的再活动性;此外,该类化合物可能展示生物活动,这与药物应用有关.

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950514-14-4 70662-92-9 65-86-1

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CAS号950514-14-4 2-氧代-1,2-二氢嘧啶-4-羧酸甲酯

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    专利信息


    专利号:WO-2004087679-A1
    优先权日:2003-04-01
    标 题 :2, 4, 6-trisubstituted pyrimidine derivatives useful for the treatment of neoplastic and autoimmune diseases
    发明人：OBRECHT DANIEL; ERMERT PHILIPP; LUTHER ANATOL; EBERLE MARTIN; BACHMANN FELIX
    权利人:APONETICS AG; OBRECHT DANIEL; ERMERT PHILIPP; LUTHER ANATOL; EBERLE MARTIN; BACHMANN FELIX
    摘要:The invention relates to substituted pyrimidines of formula (I) wherein V represents a bond or CR6R7, W represents a bond, NR8 or oxygen, X represents sulfur, or nitrogen substituted by hydrogen or R5, Y represents -CH2-, -CH2CH2-, -CO- or -CS-, R1 represents unsubstituted or substituted aryl or heteroaryl, and the substituents R2, R3, R4, R5, R6, R7 and R8 have the meanings given in the specification. These compounds are selectively inducing apoptosis in cancer cells and can be used for the treatment of neoplastic and autoimmune diseases. The invention relates also to methods of synthesis of such compounds, to their use as medicaments, to pharmaceutical compositions containing same, and to methods of treatment of neoplastic and autoimmune diseases using such compounds of formula (I) or of pharmaceutical compositions containing same.

    专利号:US-5215997-A
    优先权日:1985-09-11
    标题:Synthesis of beta-lactam compounds
    发明人：HUNGERBUEHLER ERNST; KALVODA JAROSLAV
    权利人:CIBA GEIGY CORP
    摘要:The invention relates to an improved process for the preparation of compounds of formula ##STR1## or salts thereof, starting from compounds of formulae ##STR2## via compounds of formulae ##STR3## in which compounds R 1 is hydrogen or lower alkyl, R 2 is an organic radical which may carry a functional group which may be protected by a customary protective group R 2 o , R 3 is hydrogen or a customary carboxyl protective group R 3 o , W is a group which can be replaced by a thiocarboxylic acid radical of formula III, and Z is oxygen or sulfur.

    专利号:EP-0215739-A1
    优先权日:1985-09-11
    标题:Synthesis of beta-lactam compounds

    专利号:EP-0215739-B1
    优先权日:1985-09-11
    标 题:Synthesis of beta-lactam compounds

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    合成参考文献


    摘要:M. Claesen and H. Vanderhaeghe, Bull. Soc. Chim. Belg. 66, 292 (1957).
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