专利号:US-9567308-B1 优先权日:2015-07-23 标 题:Process for the synthesis of chlorzoxazone 发明人:BOGOGNA LUIGI; CICIONE LAVINIA; BAROZZA ALESSANDRO; ROLETTO JACOPO; PAISSONI PAOLO 权利人:PROCOS SPA 摘要:Disclosed is a process for the synthesis of chlorzoxazone (1) from 4-chloro-2-aminophenol and ethyl chloroformate in the presence of a base. n n n n n n n n n n The process is particularly advantageous because it uses ethyl chloroformate instead of triphosgene, a highly dangerous reagent that releases phosgene and must be handled with extremely strict procedures to guarantee the safety of operators in industrial facilities. n Ethyl chloroformate allows the possibility of working with a number of solvents, including water. n The yield and purity of the product obtained are very high.
专利号:WO-2013049605-A1 优先权日:2011-09-28 标题 :Processes for the preparation of an intermediate in the synthesis of eltrombopag 发明人:AVDAGIC AMIR; BARAN PHIL S 权利人:ASSIA CHEM IND LTD; TEVA PHARMACEUTICAL USA INC 摘要:3'-Amino-2'-hydroxybiphenyl-3-carboxylic acid (BPCA) and related compounds have been prepared using compounds such as: wherein R 1 is -H, -Cl or -F; R 2 is -Br or -I; and R 3 is -H or -N0 2 . BPCA is useful, for example, in the preparation of Eltrombopag.
专利号:US-2012203031-A1 优先权日:2009-10-19 标 题:Sustainable chemical process for reduction of nitro compounds (R-NO2) or nitroso compounds (R-NO) containing sulphonic or carboxylic group into corresponding amino compounds (R-NH2) with inherent recycle of all acidic streams generated in synthesis 发明人:PADIA BHADRESH K; MEHTA NITESH H 权利人:PADIA BHADRESH K; MEHTA NITESH H; NEWREKA CHEMICALS PRIVATE LTD 摘要:The process of the present invention creates a sustainable and closed water loop allowing inherent recycles of all liquid streams generated in the process. The liquid streams generated during the process of the invention are inherently recycled completely, making the process of the present invention a zero liquid discharge process which is environmentally friendly and sustainable. This invention further relates to a sustainable chemical process of reduction of R—NO 2 or R—NO into corresponding R—NH 2 that produces environmentally friendly R—NH 2 in good yields and selectivity with large of mother liquor recycle. The process has a wide scope in that it can be applied to a number of molecules.
专利号:CN-101591290-A 优先权日:2009-06-19 标题 :The back-end production process of synthesis of quinoline and derivative thereof
专利号:US-2017022172-A1 优先权日:2015-07-23 标 题:Process for the synthesis of chlorzoxazone
专利号:CN-104744311-B 优先权日:2015-04-20 标题:Synthesis method of bifenazate
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