CAS: 88150-46-3; 3-Ethyl 5-Methyl 2-((2-Azidoethoxy)Methyl)-4-(2-Chlorophenyl)-6-Methyl-1,4-Dihydropyridine-3,5-Dicarboxylate
该化合物是二羟丙烯的类别之一,其特点是含有氮的六人环.这种化合物具有多种功能组,包括,乙氧和碳箱酸奶,有助于其潜在的再活性和生物活动.二氯苯组的存在表明它可能与生物目标发生相互作用,使其对药用化学产生兴趣.经常研究二氢丙烯的药性特性,特别是作为钙通道阻塞剂.结构复杂性,包括乙基和甲基亚基亚基亚基成分,可能影响化合物的亲脂性和溶性,从而影响其生物利用率.此外,乙基苯组组可以作为进一步进行化学修改或聚合的处理工具,提高合成材料的效用.
- 英文名称3-Ethyl 5-Methyl 2-((2-Azidoethoxy)Methyl)-4-(2-Chlorophenyl)-6-Methyl-1,4-Dihydropyridine-3,5-Dicarboxylate
- 中文名称3-乙基 5-甲基 2-((2-叠氮基乙氧基)甲基)-4-(2-氯苯基)-6-甲基-1,4-二氢吡啶-3,5-二羧酸酯
- IUPAC名称3-ethyl 5-methyl 2-((2-azidoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
- 其它别名2-[(2-Azidoethoxy)Methyl]-4-(2-Chlorophenyl)-1,4-Dihydro-6-Methyl-3,5-Pyridinedicarboxylic Acid 3-Ethyl 5-Methyl Ester; Amlodipine Azido Analog; 3-O-Ethyl 5-O-Methyl 2-(2-Azidoethoxymethyl)-4-(2-Chlorophenyl)-6-Methyl-1,4-Dihydropyridine-3,5-Dicarboxylate; Azido Amlodipine; 2-[(2-Azidoethoxy)Methyl]-4-(2-Chlorophenyl)-6-Methyl-5-Methoxycarbonyl-3-Ethoxycarbonyl-1,4-Dihydropyridine; 2-[(2-Azidoethoxy)Methyl]-4-(2-Chlorophenyl)-3-(Ethoxycarbonyl)-5-(Methoxycarbonyl)-6-Methyl-1,4-Dihydropyridine; 3-Ethyl 5-Methyl 2-((2-Azidoethoxy)Methyl)-4-(2-Chlorophenyl)-6-Methyl-1,4-Dihydropyridine-3,5-Dicarboxylate; 2-[(2-Azidoethoxy)Methyl]-4-(2-Chlorophenyl)-3-(Ethoxycarbonyl)-5-(Methoxycarbonyl)-6-Methyl-1,4-Dih
- CAS编号88150-46-3
- MFCD编号:MFCD00548080
- FDA UNII编号:46GYN24JHH
- 分子式:C20H23ClN4O5分子量:434.88
- 产品CID: 1890698
- 产品分类有机原料→分子砌块→芳环类化合物→苯类化合物
相似化合物
140171-66-0 400024-12-6 721958-74-3物理性质
MSDS等安全信息
上下游产品
methanol 2-(2-azidoethoxy)methyl-5-carboxy-4-(2-chlorophenyl)-3-ethoxycarbonyl-6-methyl-1,4-dihydropyridine ethyl (2-chloroaceto)acetate ethyl 4-(2-azidoethoxy)acetoacetate 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine 3-ethyl 5-methyl 2-((2-(1H-1,2,3-triazol-1-yl)ethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate 4-(2-Chloro-phenyl)-2-[2-(5-ethoxycarbonyl-[1,2,3]triazol-1-yl)-ethoxymethyl]-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-methyl ester 4-(2-Chloro-phenyl)-2-[2-(4-ethoxycarbonyl-[1,2,3]triazol-1-yl)-ethoxymethyl]-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-methyl ester合成工艺路线路线简述
- 合成目标产物 2-[(2-Azidoethoxy)Methyl]-4-(2-Chlorophenyl)-3-Ethoxycarbonyl-5-Methoxycarbonyl)-6-Methyl-1,4-Dihydropyridine 主要起始原料 Amlodipine
- 1517-05-1 + 39562-06-6 = 88150-46-3
反应条件:1.1 Reagents: Pyridinium Tribromide Solvents: Dichloromethane; 0 °C1.2 Reagents: Sodium Hydride Solvents: Diethyl Ether; 0 °C
标题:Synthesis Of 1,4-Dihydropyridine Using Microwave-Assisted Aza-Diels-Alder Reaction And Its Application To Amlodipine
作者:Lee,Youn A.; Et Al
参考文献:Journal Of Industrial And Engineering Chemistry (Amsterdam 日期:2011 卷标:17(3) 页码:401-403]
905818-05-5 + 67593-46-8 = 88150-46-3 [标题:Reaction Conditions
标题:A Novel Method For Knoevenagel Condensation
参考文献:Taiwan]
638-07-3 + 1517-05-1 = 88150-46-3
反应条件:1.1 Reagents: Sodium Hydride Solvents: Tetrahydrofuran1.2 -2.1 Reagents: Ammonium Acetate Solvents: Ethanol2.2 -
标题:Long-Acting Dihydropyridine Calcium Antagonists. 1. 2-Alkoxymethyl Derivatives Incorporating Basic Substituents
作者:Arrowsmith,John E.; Et Al
参考文献:Journal Of Medicinal Chemistry 日期:1986 卷标:29(9) 页码:1696-702]
638-07-3 + 1517-05-1 = 88150-46-3 [标题:Reaction Conditions
标题:A Novel Method For Knoevenagel Condensation
参考文献:Taiwan]
423771-19-1 = 88150-46-3
反应条件:1.1 Reagents: Formic Acid Catalysts: Palladium Solvents: Methanol; Reflux2.1 Reagents: Pyridinium Tribromide Solvents: Dichloromethane; 0 °C2.2 Reagents: Sodium Hydride Solvents: Diethyl Ether; 0 °C
标题:Synthesis Of 1,4-Dihydropyridine Using Microwave-Assisted Aza-Diels-Alder Reaction And Its Application To Amlodipine
作者:Lee,Youn A.; Et Al
参考文献:Journal Of Industrial And Engineering Chemistry (Amsterdam 日期:2011 卷标:17(3) 页码:401-403]
423771-19-1 = 88150-46-3
反应条件:1.1 Reagents: Formic Acid Catalysts: Palladium Solvents: Methanol2.1 -2.2 -
标题:Synthesis Of Amlodipine Using Aza Diels-Alder Reaction
作者:Kim,Seok-Chan; Et Al
参考文献:Bulletin Of The Korean Chemical Society 日期:2002 卷标:23(1) 页码:143-144]
88150-45-2 = 88150-46-3 [标题:Reaction Conditions
标题:A Novel Method For Knoevenagel Condensation
参考文献:Taiwan]
88150-42-9 = 88150-46-3
反应条件:1.1 Reagents: Potassium Bicarbonate,Oxygen,Sulfuryl Azide Fluoride Solvents: Dimethylformamide,Tert-Butyl Methyl Ether,Water; 5 Min,Rt1.2 Reagents: Hydrochloric Acid Solvents: Water; Ph 1,Rt
标题:Modular Click Chemistry Libraries For Functional Screens Using A Diazotizing Reagent
作者:Meng,Genyi; Et Al
参考文献:Nature (London 日期:2019 卷标:574(7776) 页码:86-89]
1517-05-1 + 39562-06-6 = 88150-46-3 [标题:Reaction Conditions
标题:Synthesis Of Amlodipine Using Aza Diels-Alder Reaction
作者:Kim,Seok-Chan; Et Al
参考文献:Bulletin Of The Korean Chemical Society 日期:2002 卷标:23(1) 页码:143-144]
88150-45-2 + 67593-46-8 = 88150-46-3
反应条件:1.1 Reagents: Ammonium Acetate Solvents: Ethanol1.2 -
标题:Long-Acting Dihydropyridine Calcium Antagonists. 1. 2-Alkoxymethyl Derivatives Incorporating Basic Substituents
作者:Arrowsmith,John E.; Et Al
参考文献:Journal Of Medicinal Chemistry 日期:1986 卷标:29(9) 页码:1696-702]
89-98-5 + 105-45-3 = 88150-46-3 [标题:Reaction Conditions
标题:A Novel Method For Knoevenagel Condensation
参考文献:Taiwan]
23326-27-4 + 15725-22-1 = 88150-46-3
反应条件:1.1 Reagents: Sulfuric Acid Magnesium Salt (1:1); 40 S,70 °C1.2 15 Min,130 °C2.1 Reagents: Formic Acid Catalysts: Palladium Solvents: Methanol; Reflux3.1 Reagents: Pyridinium Tribromide Solvents: Dichloromethane; 0 °C3.2 Reagents: Sodium Hydride Solvents: Diethyl Ether; 0 °C
标题:Synthesis Of 1,4-Dihydropyridine Using Microwave-Assisted Aza-Diels-Alder Reaction And Its Application To Amlodipine
作者:Lee,Youn A.; Et Al
参考文献:Journal Of Industrial And Engineering Chemistry (Amsterdam 日期:2011 卷标:17(3) 页码:401-403]
24405-35-4 + 23326-27-4 = 88150-46-3
反应条件:1.1 Reagents: Sulfuric Acid Magnesium Salt (1:1) Solvents: Toluene2.1 Reagents: Formic Acid Catalysts: Palladium Solvents: Methanol3.1 -3.2 -
标题:Synthesis Of Amlodipine Using Aza Diels-Alder Reaction
作者:Kim,Seok-Chan; Et Al
参考文献:Bulletin Of The Korean Chemical Society 日期:2002 卷标:23(1) 页码:143-144]
141-97-9 + 89-98-5 = 88150-46-3
反应条件:1.1 Heated2.1 Reagents: Sulfuric Acid Magnesium Salt (1:1); 40 S,70 °C2.2 15 Min,130 °C3.1 Reagents: Formic Acid Catalysts: Palladium Solvents: Methanol; Reflux4.1 Reagents: Pyridinium Tribromide Solvents: Dichloromethane; 0 °C4.2 Reagents: Sodium Hydride Solvents: Diethyl Ether; 0 °C
标题:Synthesis Of 1,4-Dihydropyridine Using Microwave-Assisted Aza-Diels-Alder Reaction And Its Application To Amlodipine
作者:Lee,Youn A.; Et Al
参考文献:Journal Of Industrial And Engineering Chemistry (Amsterdam 日期:2011 卷标:17(3) 页码:401-403
📜氨氯地平置于fluorosulfuryl Azide,Potassium Hydrogencarbonate体系中,用 甲基叔丁基醚,水,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 0.08H,以95%的收率获得产物2-[(2-叠氮基乙氧基)甲基]-4-(2-氯苯基)-3-乙氧羰基-5-甲氧羰基)-6-甲基-1,4-二氢吡啶
参考文献:使用重氮化试剂进行功能筛选的模块化点击化学库
标题:使用重氮化试剂进行功能筛选的模块化点击化学库
摘要:点击化学是一个概念,其中模块化合成用于快速找到具有所需特性的新分子1.铜 (I) 催化的叠氮化物-炔烃环加成 (Cuaac) 三唑环化和硫 (Vi) 氟化物交换 (Sufex) 催化被广泛认为是点击反应 2-4,可快速获得其产品,产率接近 100%,同时在很大程度上是正交的到其他反应.然而,在 Cuaac 反应的情况下,由于其潜在的毒性和制备过程中涉及的爆炸风险,叠氮化物试剂的可用性受到限制.在这里,我们报告了另一种添加到点击反应家族的反应:由伯胺形成叠氮化物,伯胺是最丰富的官能团之一.该反应仅使用一当量的简单重氮化物质,氟磺酰叠氮化物 6-11 (Fso2N3),并且能够以安全实用的方式在 96 孔板上制备 1,200 多种叠氮化物.这种可靠的转化是 Cuaac 三唑环化的有力工具,这是目前使用最广泛的点击反应.该方法极大地扩展了可接近的叠氮化物和 1,2,3-三唑的数量,鉴于 Cuaac
DOI:10.1038/s41586-019-1589-1
海关参考信息
- 2901210000-乙烯
2901220000-丙烯
2902600000-乙苯
2902700000-异丙基苯 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
参考标题:Metal‐free Synthesis Of Functional 1‐substituted‐1,2,3‐triazoles From Ethenesulfonyl Fluoride And Organic Azides作者:Marie‐claire Giel,Christopher J. Smedley,Emily R. R. Mackie,Taijie Guo,Jiajia Dong,Tatiana P. Soares Da Costa,John E. Moses |发布日期:2020.1.13
摘要:Scalable Click-Inspired Protocol For The Synthesis Of 1-Substituted-1,2,3-Triazoles From Organic Azides And The Bench Stable Acetylene Surrogate Ethenesulfonyl Fluoride (Esf). The New Transformation Tolerates A Wide Selection Of Substrates And Proceeds Smoothly Under Metal-Free Conditions To Give The Products In Excellent Yield. Under Controlled Acidic Conditions, The 1-Substituted-1,2,3-Triazole Products
合成参考文献
摘要:Kleemann, A.; Engel, J.; Kutscher, B.; Reichert, D., Pharmaceutical Substances[Online], Thieme: Stuttgart, (2003).
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