CAS: 723-62-6; Anthracene-9-Carboxylic Acid

该化合物是一种芳香的碳酸,其特点是由三根有引信的苯环组成的炭疽脊椎;该化合物的特点是附于炭疽结构的第九碳的碳酸性功能组(-COOH),在室内温度一般是固体,由于其硬性多环结构,呈现出一个高熔点;该碳酸组的存在具有酸性,允许它参与各种化学反应,例如酯化和恐吓. 9-Anthresencarboxylic酸因其在有机合成中的应用而闻名,特别是在染料,药品的研制和材料科学的建筑块中应用.此外,它可以展示荧光,使其在光学应用中有用.该化合物一般在标准条件下是稳定的,但应对其潜在的反应和实验室环境需要适当的安全措施而加以处理.

结构式图片

相似化合物

1468-95-7 642-31-9 1210-12-4

欧盟法规

REACH注册ECHA物质C&L通报REACH预注册

上下游产品

CAS号124-38-9 二氧化碳 | CAS号120-12-7 蒽 | CAS号22362-86-3 9-碘蒽 | CAS号642-31-9 9-蒽醛 | CAS号1564-64-3 9-溴蒽 | CAS号201230-82-2 carbon monoxide | CAS号79-37-8 草酰氯 | CAS号141-82-2 丙二酸 | CAS号40476-29-7 10-methylidene-... | CAS号20202-05-5 9,10-ethanoanth... | CAS号613-31-0 9,10-二氢蒽 | CAS号120-12-7 蒽 | CAS号1143-20-0 9-Anthracenecar... | CAS号84-65-1 蒽醌 | CAS号779-03-3 9-氨基蒽 | CAS号523-27-3 9,10-二溴蒽 | CAS号6929-81-3 10-溴蒽-9-甲酸 | CAS号605-48-1 9,10-二氯蒽 | CAS号6929-82-4 10-chloroanthra...

合成工艺路线路线简述

  • 合成目标产物 Anthracene-9-Carboxylic Acid 主要起始原料 9-Anthraldehyde
  • (文献来源)合成步骤主要原料 9-Anthraldehyde
9-蒽甲醛肟置于硫酸,水体系中,化学反应生成 9-蒽甲酸
参考文献:A Mild Oxidation Of Deactivated Naphthalenes And Anthracenes To Corresponding Para-Quinones By N-Bromosuccinimide
标题:A Mild Oxidation Of Deactivated Naphthalenes And Anthracenes To Corresponding Para-Quinones By N-Bromosuccinimide
摘要:
DOI:10.1016/j.Tetlet.2014.04.088

海关参考信息

专利信息


专利号:US-6924375-B2
优先权日:2003-09-03
标题:Facile synthesis of 1,9-diacyldipyrromethanes
发明人:LINDSEY JONATHAN S; TAMARU SHUN-ICHI; YU LIANHE
权利人:UNIV NORTH CAROLINA STATE
摘要:The present invention provides a method of making a metal complex. The method comprises the steps of: (a) acylating a dipyrromethane or a 1-monoacyldipyrromethane to form a mixed reaction product comprising a 1,9-diacyidipyrromethane; (b) combining the reaction product with a compound of the formula R 2 MX 2 in the presence of a base, where R is alkyl or aryl, M is Sn, Si, Ge, or Pb (preferably Sn), and X is halo, OAc, acac, or OTf, to form a product comprising a metal complex of the formula DMR 2 in the mixed reaction product, wherein D is a 1,9-diacyldipyrromethane; and then (c) separating the metal complex from the mixed reaction product. The method may be utilized for the convenient synthesis and separation of 1,9-diacyldipyrromethanes. Metal complex intermediates useful in such methods are also described.

专利号:US-12441733-B2
优先权日:2018-03-26
标题:Substituted 2,4-dioxotetrahydropyrimidines as intermediates in the synthesis of bruton's tyrosine kinase inhibitors
发明人:ARISTA LUCA; HEBACH CHRISTINA; HOLLINGWORTH GREGORY JOHN; HOLZER PHILIPP; IMBACH-WEESE PATRICIA; LORBER JULIEN; MACHAUER RAINER; SCHMIEDEBERG NIKO; VULPETTI ANNA; ZOLLER THOMAS
权利人:NOVARTIS AG
摘要:The invention relates to compounds of the formulae (I), (III), (IIIa), (XXIa), (XXIII), and/or (XLVI)or a pharmaceutically acceptable salt thereof, wherein the substituents are as defined in the specification; to intermediates in the preparation of the compounds, to pharmaceutical compositions comprising the compounds and to use of the compounds in the treatment of disease.

专利号:US-7846714-B2
优先权日:1998-09-17
标 题 :Synthesis of chemical tags
发明人:SARAF RAVI F
权利人:IBM
摘要:A method for forming a biological chemical tag. At least one double stranded DNA molecule is provided. At least a portion of the at least one double stranded DNA molecule is denatured. At least one chemical moiety that prohibits recrystallization of the at least one denatured portion to which the at least one chemical moiety is attached is attached to at least one nucleotide in the at least one denatured portion of the at least one double stranded DNA molecule.

专利号:US-2011028688-A1
优先权日:2006-06-21
标 题 :Crystal structure of ox40l and ox40l complexed with ox40 receptor
发明人:HYMOWITZ SARAH; COMPAAN MCGUINN DEANNE
权利人:GENENTECH INC
摘要:The present disclosure provides crystals of and structural coordinates of mOX40L, hOX40L, hOX40 receptor and complexes thereof. The crystals and crystal structures are useful, for example, in the design and synthesis of modulators of mOX40L, hOX40L, and/or hOX40 receptor.

专利号:CN-111171080-B
优先权日:2020-01-08
标 题:Cell and in vivo autocatalytic synthesis of high-efficiency and low-toxicity anticancer compounds and their synthesis methods

专利号:US-6531470-B1
优先权日:1998-01-23
标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人:GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.
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主要参考文献

[参考文献]: Cherian Ol, Menini A, Boccaccio A. Multiple Effects Of Anthracene-9-Carboxylic Acid On The Tmem16B/anoctamin2 Calcium-Activated Chloride Channel. Biochim Biophys Acta. 2015 Apr;1848(4):1005-13.
[参考文献]: Piper As, Greenwood Ia. Anomalous Effect Of Anthracene-9-Carboxylic Acid On Calcium-Activated Chloride Currents In Rabbit Pulmonary Artery Smooth Muscle Cells. Br J Pharmacol. 2003 Jan;138(1):31-8.
[参考文献]: Diego Crespo, Et Al. Tumor Necrosis Factor Alpha May Act As An Intraovarian Mediator Of Luteinizing Hormone-Induced Oocyte Maturation In Trout. Biol Reprod. 2012 Jan 10;86(1):1-12.
[参考文献]: H A Azab, Et Al. Synthesis And Fluorescence Properties Of Eu-Anthracene-9-Carboxylic Acid Towards N-Acetyl Amino Acids And Nucleotides In Different Solvents. Spectrochim Acta A Mol Biomol Spectrosc. 2010 Jan;75(1):21-7.
[参考文献]: Joon-Chul Kim, Et Al. Shear Stress Induces A Longitudinal Ca(2+) Wave Via Autocrine Activation Of P2Y1 Purinergic Signalling In Rat Atrial Myocytes. J Physiol. 2015 Dec 1;593(23):5091-109.

合成参考文献


参考文献:10.1107/s0108270196011213|10.1107/s0108270197004927
摘要:Fitzgerald LJ, Gerkin RE. Anthracene-1-carboxylic acid. Acta Crystallogr C. 1997 Aug 15;53 ( Pt 8)():1080–2. doi: 10.1107/s0108270197004927.
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