2,3,4-三溴吡啶置于palladium On Activated Charcoal Sodium Hydroxide,氢气,Sodium Methylate体系中,用 甲醇,乙醇 作为反应溶剂,23.0~140.0 °C,273.58 Kpa 条件下,反应 3.25H,反应生成 4-甲氧基吡啶 参考文献:Rearrangements Of Azabiphenylenes. The Impact Of Nitrogen Number And Position 标题:Rearrangements Of Azabiphenylenes. The Impact Of Nitrogen Number And Position 摘要: DOI:10.1021/jo00214A012
专利号:US-10011567-B1 优先权日:2017-03-09 标题 :Method for the synthesis of acrylate derivatives 发明人:WANG MINGWEN; ZHANG YUE 权利人:INNOSCI LLC 摘要:The present invention provides an improved synthesis of a salt of acrylate derivatives. The synthesis generally includes the preparation of an ester or an amide containing a leaving group followed by the formation of a salt.
专利号:US-11465970-B2 优先权日:2017-12-14 标题 :Method for synthesis of Roxadustat and intermediate compounds thereof 发明人:XU YONGXIANG 权利人:NANJING CAVENDISH BIO ENGINEERING TECH CO LTD; XU YONGXIANG; NANJING CAVENDISH BIO ENG TECH CO LTD 摘要:The present application provides a method for synthesis of Roxadustat. A compound as represented by formula (VIII) is used as a raw material, and is reacted with phenol, a vinyl-containing ether, an acid, hydroxylamine, and then the product is reacted with glycine. In addition, the present application also provides intermediate compounds as represented by formula (IX), formula (XI), formula (XII), formula (IV), and formula (V) for synthesis of Roxadustat. Herein, details of the substituents involved in formula (VIII), formula (IX), formula (XI), and formula (XII) are stated in the description
专利号:US-4801744-A 优先权日:1985-03-01 标 题 :Catalytic synthesis of urea from carbon monoxide and amine compound 发明人:HERMAN JEAN-JACQUES; LECLOUX ANDRE 权利人:SOLVAY 摘要:Process for the catalytic synthesis of nitrogen-containing organic compounds, comprising the reaction of carbon monoxide with at least one amino compound in a reaction mixture containing a catalyst based on selenium and a substituted pyridine. The process is particularly suitable for the synthesis of ureas and of their polymers.
专利号:US-2023339844-A1 优先权日:2020-09-17 标题:A process for the synthesis of anthranilic acid/amide compounds and intermediates thereof 发明人:MAHAPATRA TRIDIB; PATRA PRANAB KUMAR; KLAUSENER ALEXANDER G M; MAL SANJIB; SHARMA RAJU 权利人:PI INDUSTRIES LTD; PI INDUSTRIES LTD 摘要:The present invention disclosed a process for the synthesis of compound of formula (Z) or a salt thereof, n n n n n n n n n n wherein, R, R 1 , R 2 , R 3 and R 10 are as defined in the detailed description. The process further comprises the synthesis of an anthranilic diamide compound of formula (I).
专利号:US-2023339906-A1 优先权日:2020-09-26 标 题 :A process for the synthesis of anthranilic acid/amide compounds and intermediates thereof 发明人:SYTHANA SURESH KUMAR; NAGLE PRAMOD; KUMAR VIJAY KUMAR; KANAWADE SHRIKANT BHAUSAHEB; CHANDRE TUKARAM NIVRUTTI; THUBE VINAYAK KISAN; PATIL PRADEEP PRAKASH; SHUKLA SHALINI; SHENDE KANTILAL BALU; PATRA PRANAB KUMAR; KLAUSENER ALEXANDER G M 权利人:PI INDUSTRIES LTD; PI INDUSTRIES LTD 摘要:The present invention discloses a process for the synthesis of compound of formula (VII) or a salt thereof,wherein, R, R1, R2, R3, R4a and R4b are as defined in the detailed description. The process further comprises the synthesis of an anthranilic diamide compound of formula (I).
专利号:US-2023286893-A1 优先权日:2022-03-09 标题 :Vanillylidenechloroacetone and its use thereof in synthesis of calebin-a 发明人:MAJEED MUHAMMED; NAGABHUSHANAM KALYANAM; MUTHUKAMAN NAGARAJAN; PENTAKOTA PARADESI NAIDU 权利人:MAJEED MUHAMMED; NAGABHUSHANAM KALYANAM; MUTHUKAMAN NAGARAJAN; PENTAKOTA PARADESI NAIDU 摘要:The present invention discloses a compound, Vanillylidenechloroacetone (VCA)—1-Chloro-4-(4′-hydroxy-3′-methoxy-phenyl)-but-3-en-2-one, and the process of preparing the same. The invention also discloses a process for synthesis of Calebin-A from Vanillylidenechloroacetone.
[参考文献]: Iu Iu Vol'Dman, Et Al. [参考文献]: Bioorg Khim. 1989 Aug;15(8):1044-55. [参考文献]: Woldman Yayu, Et Al. Nmr Study Of The Interaction Of P-450 With 4-Methoxypyridine. Febs Lett. 1987 Feb 9;212(1):53-7.
合成参考文献
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