专利号:US-2016185745-A1 优先权日:2013-08-07 标题:Analogs of vinaxanthone and xanthofulvin, methods of synthesis, and methods of treatments thereof 发明人:SIEGEL DIONICIO; CHIN MATTHEW; ELIASEN ANDERS; AXELROD ABRAM 权利人:UNIV TEXAS 摘要:The present invention relates generally to methods of synthesis of vinaxanthone and xanthofulvin, novel analogs, and methods of use thereof.
专利号:US-10065924-B2 优先权日:2014-07-22 标 题 :Preparation and biological evaluation of viridicatumtoxin analogs 发明人:NICOLAOU KYRIACOS C; HALE CHRISTOPHER R H; NILEWSKI CHRISTIAN; IOANNIDOU HERAKLIDIA; EL MARROUNI ABDELLATIF 权利人:UNIV RICE WILLIAM M 摘要:In one aspect, the present invention provides novel derivatives of viridicatumtoxin of the formula wherein the variables are as defined herein. The application also provides compositions, methods of treatment, and methods of synthesis thereof.
专利号:US-2016312261-A1 优先权日:2015-04-24 标 题 :Enzymatic production of cytosinic nucleoside analogues 发明人:PASCUAL GILABERT MARTA; DERONCELÉ THOMAS VICTOR M; MONTILLA ARÉVALO RAFAEL 权利人:PLASMIA BIOTECH S L 摘要:The invention relates to the enzymatic production of cytosinic nucleoside analogues. In particular it relates to a new synthesis process of cytosine nucleoside analogues by using nucleoside phosphorylase enzymes, particularly Pyrimidin Nucleoside Phosphorylases (PyNPs) or mixtures of Purine Nucleoside Phosphorylases (PNPs) and PyNPs.
专利号:EP-2883959-A1 优先权日:2013-12-13 标 题:Enzymatic production of cytosinic nucleoside analogues 发明人:PASCUAL GILABERT MARTA; DERONCELÉ THOMAS VÃ?CTOR M; MONTILLA ARÉVALO RAFAEL 权利人:PLASMIA BIOTECH S L 摘要:The invention relates to a new synthesis process of cytosine nucleoside analogues by using nucleoside phosphorylase enzymes, particularly Pyrimidin Nucleoside Phosphorylases (PyNPs) or mixtures of Purine Nucleoside Phosphorylases (PNPs) and PyNPs.
专利号:US-9295731-B2 优先权日:2013-04-01 标题 :Cleavable drug conjugates, compositions thereof and methods of use 发明人:NGUYEN MARK QUANG 权利人:NGUYEN MARK QUANG 摘要:Base-labile crosslinkers, base-labile conjugates comprising such crosslinkers, methods of their synthesis and use are disclosed.
专利号:WO-2012062907-A1 优先权日:2010-11-12 标题 :Nucleic acidsbuilding blocks and methods for the synthesis of 5-hydroxymethylcytosine-containing
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