CAS: 59129-79-2; 6'-(Ethyl(P-Tolyl)Amino)-3'-Methyl-2'-(Phenylamino)-3H-Spiro[isobenzofuran-1,9'-Xanthen]-3-One

相似化合物

29512-49-0 36431-22-8 89331-94-2

上下游产品

4-phenylamino-3-methyl-1-methoxybenzene 2-[4-(Ethyl-p-tolyl-amino)-2-hydroxy-benzoyl]-benzoic acid

📜3-(5-Anilino-2-Methoxy-4-Methylphenyl)-3-[4-(N-Ethyl-4-Methylanilino)-2-Hydroxyphenyl]-2-Benzofuran-1-One置于sodium Hydroxide体系中,用 水,甲苯 作为反应溶剂,以85%的收率获得产物6-[乙基(4-甲基苯基)氨基]-3-甲基-2-(苯基氨基)-螺[异苯并呋喃-1(3H),9-(9H)占吨]-3-酮
参考文献:一种合成荧烷类黑色热压敏成色剂的方法
标题:一种合成荧烷类黑色热压敏成色剂的方法
摘要:本发明提供一种合成荧烷类黑色热压敏成色剂的方法,使用二苯酮酸和2‑甲基‑4‑甲氧基‑二苯胺作为原料,并且所述方法包括如下步骤:将二苯酮酸,2‑甲基‑4‑甲氧基‑二苯胺和催化剂加入有机溶剂中反应,反应结束后将反应液过滤获得滤液;将滤液加水并调节ph＞10后加热回流分去水相获得有机相;将有机相冷却结晶,过滤即获得荧烷类成色剂.本发明中制备的成色剂中具有芳基,代替了传统黑色成色剂中的烷基,这进一步增大了成色剂分子中共轭体系,增大了成色剂的吸光强度;其采用高效且可回收套用的固体酸催化剂,减少了制备过程中酸和碱的用量,且大大减少了废酸废水的排放量,节约了生产成本,且更加绿色环保.

专利信息

专利号:US-6096874-A
优先权日:1990-10-01
标 题:High affinity tamoxifen derivatives
发明人：WALLACE SIDNEY; YANG DAVID; DELPASSAND EBRAHIM; CHERIF ABDALLAH; QUADRI SYED M
权利人:UNIV TEXAS
摘要:The synthesis of tamoxifen derivatives, most particularly halo, halo alkyl, hydroxy, and amino tamoxifen derivatives is disclosed. The native tamoxifen molecule includes a substituted chemical group positioned on the aliphatic chain of the tamoxifen molecule. Particular tamoxifen derivatives of the invention include chloro, bromo, iodo, fluoro, amino and DTPA tamoxifen derivatives, and corresponding lower alkyl halogenated forms. The halogenated tamoxifen derivatives possess superior binding affinities for estrogen receptor rich tissues, such as uterine tissue and breast tissue, relative to unsubstituted native tamoxifen. Radiolabeled forms of the tamoxifen derivatives may be used as highly specific imaging agents for estrogen receptor rich tissues. The fluoro and bromo tamoxifen derivatives are particularly useful for imaging estrogen receptors by PET whereas the iodinated tamoxifens are particularly useful in imaging estrogen receptors by SPECT. Rapid and efficient methods of preparing the tamoxifen derivatives having high specific activity (>6 Ci/μmol) are also disclosed. Aliphatic chain substituted tamoxifen derivatives are shown to possess greater estrogen receptor binding affinity and more potent tumor cell inhibition than tamoxifen or tamoxifen derivatives substituted at other locations on the molecule (i.e., non-aliphatic chain substituted tamoxifen). The tanioxifen derivatives of the present invention may advantageously be used as anti-cancer therapeutic agents to halt estrogen-receptor positive tumors, such as those of breast and uterine tissue. The present invention also provides a hydrophilic DTPA-tamnoxifen analogue, and uses thereof in imaging estrogen receptor positive ER+ lesions.

专利号:US-6946570-B2
优先权日:1997-12-23
标 题:Ester synthesis
发明人：BECKER STANLEY JOHN; BRYNE GEOFFREY; FROOM SIMON FREDERICK THOMAS; HODGE STEPHEN ROBERT
权利人:BP CHEM INT LTD
摘要:This invention relates to a process for the production of lower aliphatic esters by reacting a lower olefin with a saturated lower aliphatic mono-carboxylic acid in the vapor phase in the presence of a heteropolyacid catalyst in a plurality of reactors set up in series such that the reactant gases exiting from a first reactor are fed as the feed gas to a second reactor and those exiting from the second reactor are fed as the feed gas to a third reactor and so on for the subsequent reactors. An aliquot of the reactant monocarboxylic acid is introduced into the feed gas to the second and subsequent reactors so as to maintain the olefin to monocarboxylic acid ratio in the feed gas to each of the second and subsequent reactors within a pre-determined range.

专利号:CA-1236819-A
优先权日:1984-02-02
标题 :Catalyst and process for the synthesis of methanol and alcohol mixtures containing higher alcohols