专利号:US-4782162-A 优先权日:1984-05-17 标 题:Novel intermediates for the synthesis of cephalosporins 发明人:BOBERG MICHAEL; NAAB PAUL; SAMAAN SAMIR 权利人:BAYER AG 摘要:The new compounds of the formula ##STR1## in which Acyl is alkylcarbonyl optionally substituted by halogen or aryl, or arylcarbonyl, which is substituted by lower alkoxy, halogen or nitro, n R 1 is an alkyl or alkenyl radical, and n R 4 is an optionally substituted branched or straight-chain C 1 -C 6 -alkyl radical or a cycloalkyl radical, n are produced by reacting a 2-halogenoacetylacrylic acid ester of the formula ##STR2## with an acylthiourea of the formula ##STR3## The reaction can be conducted in aqueous DMF, substantially pure Z-isomer selectively crystallizing out.
专利号:WO-2011156355-A1 优先权日:2010-06-09 标题 :Production method of phenyl guanidine salts and their intermediates 发明人:JOHNSON MICHAEL ROSS; KANG MYUNG-CHOL; BRAY BRIAN L; SCHNEIDER STEPHEN 权利人:KAINOS MEDICINE INC; JOHNSON MICHAEL ROSS; KANG MYUNG-CHOL; BRAY BRIAN L; SCHNEIDER STEPHEN 摘要:This invention relates to methods for producing phenyl guanidine salts having pharmacological activity, as well as to the identification and synthesis of compounds useful as intermediates for producing phenyl guanidine salts having pharmacological activity.
专利号:US-4794186-A 优先权日:1983-12-21 标题:Thiazolylacetic acid derivative and processes for preparing the same 发明人:OINE TOYONARI; YAMADA YOSHIHISA; SUGANO HIROSHI 权利人:TANABE SEIYAKU CO 摘要:Novel thiazolylacetic acid derivative of the formula: ##STR1## wherein R 1 N H-- is amino or a protected amino group, R 2 is hydrogen or lower alkyl, --COOR 3 is carboxy or a protected carboxy group and n is an integer of 2 or 3, and processes for preparing the same. The compound (I) is useful as an intermediate in the synthesis of cephalosporins.
专利号:US-8203002-B2 优先权日:2004-03-19 标 题:Intermediates for the preparation of pramipexole 发明人:CASTALDI GRAZIANO; BOLOGNA ALBERTO; ALLEGRINI PIETRO; RAZZETTI GABRIELE; LUCCHINI VITTORIO 权利人:CASTALDI GRAZIANO; BOLOGNA ALBERTO; ALLEGRINI PIETRO; RAZZETTI GABRIELE; LUCCHINI VITTORIO; DIPHARMA SPA 摘要:Intermediates useful for the preparation of pramipexole and the use thereof in such synthesis.
专利号:DE-3418376-A1 优先权日:1984-05-17 标题 :INTERMEDIATE PRODUCTS AND METHOD FOR THE PRODUCTION OF INTERMEDIATE PRODUCTS FOR THE SYNTHESIS OF CEPHALOSPORINES
专利号:EP-0161617-A2 优先权日:1984-05-17 标题:Intermediates and process for the preparation of intermediates in the synthesis of cephalosporins
摘要:Koutentis, P. A.; Ioannidou, H. A., Science of Synthesis Knowledge Updates, (2010) 1, 285. 摘要:Koutentis, P. A.; Ioannidou, H. A., Science of Synthesis Knowledge Updates, (2010) 1, 277. 摘要:Koutentis, P. A.; Ioannidou, H. A., Science of Synthesis Knowledge Updates, (2010) 1, 280. 摘要:Journal of Pharmacology and Experimental Therapeutics., 97(478), 1949 [] 摘要:Archives of Environmental Contamination and Toxicology., 14(111), 1985 []