CAS: 5100-34-5; Ethyl 3-Isocyanatopropanoate

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CAS号75-44-5 光气 | CAS号4244-84-2 β-丙氨酸乙酯盐酸盐 | CAS号7364-55-8 N-trimethylsila... | CAS号924-73-2 3-氨基丙酸乙酯 | CAS号503-38-8 氯甲酸三氯甲酯 | CAS号685544-95-0 Ethyl N-[(2-{4-...

Beta-丙氨酸乙酯盐酸盐置于三乙胺体系中,用 甲苯,苯 作为反应溶剂,化学反应 2.0H,反应生成 乙基3-丙烯酸酯
参考文献:Organosilicon Synthesis Of Isocyanates: Iii. Synthesis Of Aliphatic,Carbocyclic,Aromatic,And Alkylaromatic Isocyanatocatboxylic Acid Esters
标题:Organosilicon Synthesis Of Isocyanates: Iii. Synthesis Of Aliphatic,Carbocyclic,Aromatic,And Alkylaromatic Isocyanatocatboxylic Acid Esters
摘要:A Series Of Aminoacid Esters Was Prepared By Treating The Aminoacid Suspensions In Ethanol With Thionyl Chloride. Best Conversion Of Aminoacid Esters To Corresponding Isocyanates Was Achieved In The Case Of Aromatic And Carbocyclic Aminoesters By Phosgeneation Of Their N-Silyl Derivatives,And In The Case Of Aliphatic And Alkylaromatic Aminoesters By Phosgeneation Of O-Silyl Or N,O-Bissilylurethanes On Their Basis. In The Last Case Additional Step Of Esterification Of The By-Products Isocyanatoalkylcarboxylic Acid Chlorides Is Reqired After Phosgeneation. Unusual Generation Of Cynnamates And Intramolecular N-> O-Migration Of Trimethylsilyl Group In The Solutions Of Silylated Alkylaromatic Beta-Aminoacid Esters Were Found.
DOI:10.1134/s1070363206070115

专利信息

专利号:US-6177087-B1
优先权日:1994-06-24
标 题:Non-antigenic amine derived polymers and polymer conjugates
发明人：GREENWALD RICHARD B; MARTINEZ ANTHONY; PENDRI ANNAPURNA
权利人:ENZON INC
摘要:Substantially non-antigenic polymers containing pI and/or pH optimum modulating moieties are disclosed. The polymers are useful as intermediates for synthesis of amine-based polymers and in the formation of activated polymers for conjugation with nucleophiles. Conjugates and methods of preparation and treatment with the conjugates are also disclosed.

专利号:US-9833457-B2
优先权日:2008-01-25
标题:Tricyclic compounds as modulators of TNF-α synthesis and as PDE4 inhibitors
发明人：MJALLI ADNAN M M; GADDAM BAPU; POLISETTI DHARMA RAO; KOSTURA MATTHEW J; GUZEL MUSTAFA
权利人:VTV THERAPEUTICS LLC
摘要:The present invention relates to chemical compounds of Formula (I) are as herein defined, pharmaceutical compositions, and methods of use in the treatment of conditions or disorders mediated by TNF-α or by PDE4, including but not limited to psoriatic arthritis.

专利号:US-4171438-A
优先权日:1975-07-23
标 题:0-2-Isocephem-4-carboxylic acid derivatives as antibacterial agents
发明人：DOUGLAS JAMES L; HORNING DONALD E; MORRIS LEESON R
权利人:BRISTOL MYERS CO
摘要:There is described the stereoselective total synthesis of novel DELTA 2,3-1,4-morpholine-2-carboxylic acids possessing a fused beta -lactam ring in the 1,6-position and carrying a substituent cis to carbon 5 in the 7-position of the fused ring system represented by the general formula I wherein X is acylamino and Z represents optionally substituted C1-C6 alkyl, aryl or aralkyl. Also included in the invention are compounds of the above formula in which the carboxyl group at the 2-position is protected as by an easily cleavable ester group and salts of both the free acids and carboxyl-protected compounds. The compounds are potent antibacterial agents.

专利号:US-4118566-A
优先权日:1975-07-23
标 题:Δ2,3 -1,4-Morpholine-2-carboxylic acid derivatives as antibacterial agents
发明人：HORNING DONALD E; MORRIS LEESON R; DOUGLAS JAMES L
权利人:BRISTOL MYERS CO
摘要:There is described the stereoselective total synthesis of novel DELTA 2,3-1,4-morpholine-2-carboxylic acids possessing a fused beta -lactam ring in the 1,6-position and carrying a substituent cis to carbon 5 in the 7-position of the fused ring system represented by the general formula I wherein X is amino, azido or acylamido and Z represents optionally substituted C1-C6 alkyl, aryl, aralkyl or heterocyclic. Also included in the invention are compounds of formula I in which the carboxyl group at the 2-position is protected as by an easily cleavable ester group and salts of both the free acids and carboxyl-protected compounds of formula I. The compounds of formula I are potent antibacterial agents or are of use as intermediates in the preparation of such antibacterial agents.

专利号:US-2008200475-A1
优先权日:2005-03-28
标题:4-Piperazinothieno[2,3-D] Pyrimidine Compounds As Platelet Aggregation Inhibitors
发明人：ENNIS MICHAEL DALTON; KORTUM STEVEN WADE; TENBRINK RUTH ELIZABETH
权利人:PFIZER
摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I: (I) wherein A 1 , A 2 , A 3 , A 4 , A 5 , A 6 , A 7 , A 8 , X 4 , X 6 , R 2a , R x , R 4 , R 5 , and R 6 are as defined in the detailed description of the invention. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

专利号:WO-2009094528-A1
优先权日:2008-01-25
标 题:TRICYCLIC COMPOUNDS AS MODULATORS OF TNF-α SYNTHESIS AND AS PDE4 INHIBITORS