CAS: 4767-03-7; 3-Hydroxy-2-(Hydroxymethyl)-2-Methylpropanoic Acid

上下游产品

CAS号18516-18-2 3-羟基-2-(羟基甲基)-2-甲基丙醛 | CAS号98960-49-7 3-acetoxy-2-ace... | CAS号17872-55-8 3-Hydroxy-2-hyd... | CAS号219529-78-9 2-(4-methoxyphe... | CAS号839720-60-4 5-甲基-2-苯基-1,3,2... | CAS号16837-14-2 2,2,5-三甲基-1,3-二... | CAS号162635-04-3 Temsirolimus (C... | CAS号17872-59-2 2,2-DI(ACETOXYM... | CAS号174822-36-7 bis-mpa-diallyl... | CAS号179388-73-9 2,2-BIS-(HYDROX... | CAS号919988-15-1 prop-2-ynyl 2,2... | CAS号51689-18-0 ethyl 3-hydroxy...

2,2-二(羟基甲基)丙酸甲酯置于氢氧化钾体系中,化学反应生成 2,2-二羟甲基丙酸
参考文献:Vieregge; Arens,Recueil Des Travaux Chimiques Des Pays-Bas,1959,Vol. 78,P. 921,923
标题:Vieregge; Arens,Recueil Des Travaux Chimiques Des Pays-Bas,1959,Vol. 78,P. 921,923

专利信息

专利号:US-11939264-B1
优先权日:2022-11-22
标题:Preparation method for hydrothermal synthesis of fly ash silicate aggregate
发明人：CHEN SHENGQIANG; ZHAI ZHUHE; ZHANG BING; SHANGGUAN LINJIAN; CHEN RUIXIAO; LI LUYANG; YANG GE; HAN MING; LI GUOWANG; YIN RUI; WANG TINGTING; LIU YONGCHUAN; CHEN DAN
权利人:HENAN BUILDING MATERIALS RES AND DESIGN INSTITUTE CO LTD
摘要:The present disclosure provides a preparation method for hydrothermal synthesis of fly ash silicate aggregate including: mixing sodium metasilicate, potassium hydroxide, and inorganic-organic hybrid excitation monomer as raw materials to obtain an inorganic-organic composite activator; preparing a silicate aggregate raw material, mixing measured fly ash, carbide slag, quicklime, and vitrified micro bubble by mass, adding the inorganic-organic composite activator and continue stirring to produce a mixture; forming a ball disc, wetting an expanded perlite that forms a core of the ball by spraying water, adding a prepared mixture, spraying water while adding, standing and curing, performing a maturation and activation treatment in an autoclave, undergoing a silicon calcium reaction for a hydrothermal synthesis to obtain the silicate aggregates. The present disclosure obtains silicate aggregates with high-performance by accelerating an internal activity of fly ash at an early stage and fully activating the activity of fly ash in all process.

专利号:US-7202256-B2
优先权日:2004-04-14
标题:Proline CCI-779, production of and uses therefor, and two-step enzymatic synthesis of proline CCI-779 and CCI-779
发明人：GU JIANXIN; RUPPEN MARK E; RAVEENDRANATH PANOLIL; CHEW WARREN; SHAW CHIA-CHENG
权利人:WYETH CORP
摘要:Methods for the synthesis of CCI-779 and proline-CCI-779 are described, including a method involving lipase-catalyzed acetylation of 42-hydroxy of rapamycin with a vinyl ester of 2,2-bis(hydroxymethyl) propionic acid in an organic solvent followed by deprotection. Also provided are products containing proline-CCI-779 and uses thereof.

专利号:US-7268144-B2
优先权日:2004-04-14
标 题 :Regiospecific synthesis of rapamycin 42-ester derivatives
发明人：GU JIANXIN; CAI PING; RUPPEN MARK E
权利人:WYETH CORP
摘要:A method for the regiospecific synthesis of rapamycin 42-ester derivatives is described. The method involves lipase-catalyzed acetylation of 42-hydroxy of rapamycin with an acyl donor such as a vinyl ester, an isopropenyl ester or an anhydride in a suitable organic solvent.

专利号:US-8258299-B2
优先权日:2009-03-27
标题:Process for preparation of temsirolimus
发明人：LEE KWANG-CHUNG; LEE TING-HUEI; TUNG YEN-SHIH; KAO CHIA-CHEN; LEE TZU-AI
权利人:LEE KWANG-CHUNG; LEE TING-HUEI; TUNG YEN-SHIH; KAO CHIA-CHEN; LEE TZU-AI; CHUNGWA CHEMICAL SYNTHESIS & BIOTECH CO LTD
摘要:The present invention provides two synthetic routes for the preparation of Temsirolimus (compound 1b and analog of Temsirolimus 1a). The first route includes the synthesis of CCI-779 by directly reacting rapamycin (4b) or Prolyl-rapamycin (4a) with substituent-2,2-bis(methoxy) propionic acid anhydride(11) in the presence of an organic base, followed by deprotection to give CCI-779 or Proline CCI-779. The second route includes a process involving a reaction of rapamycin-OH-31-sily ether (4d) or Prolyl-rapamycin-OH-31-sily ether (4c) with substituent-2,2-bis(methoxy) propionic acid anhydride(11) in the presence of an organic base and followed by subsequent hydrolysis step to obtain the desired CCI-779 or Proline CCI-779. n Compound 11, as described in this invention, is stable at room temperature, cost effective and ease of processing.

专利号:WO-9900440-A1
优先权日:1997-06-26
标 题:Synthesis of a dendritic polyalcohol
发明人：IHRE HENRIK; HULT ANDERS
权利人:PERSTORP AB; IHRE HENRIK; HULT ANDERS
摘要:A process for a double stage convergent synthesis of a polymeric polyalcohol substantially and preferably built up from polyester units and composed of a monomeric or polymeric core to which at least one hyperbranched dendritic branch (dendron) consisting of a number of branching generations is added. The branching generations comprise a polymeric or monomeric branching chain extender having three reactive functions of which two are hydroxyl groups and one is a carboxyl group. The two hydroxyl groups of the branching chain extender is in a first step ketal protected by reacting said two hydroxyl groups with a ketal. A second step includes protection of the carboxyl group of said branching chain extender. The ketal protected branching chain extender and the carboxyl protected chain extender are then employed for repeated addition in a number of step yielding a predetermined number of branching generations. The thus synthesized dendron is finally added to a core having reactive hydroxyl or epoxide groups and the ketal protected hydroxyl groups are optionally deprotected.

专利号:US-11034664-B1
优先权日:2020-05-11
标题 :Synthesis of cyclic carbonate monomers
发明人：PARK NATHANIEL H; HEDRICK JAMES L; PIUNOVA VICTORIA A; ARRECHEA PEDRO; ERDMANN TIM
权利人:IBM
摘要:Techniques regarding the synthesis of cyclic carbonate monomers are provided. For example, one or more embodiments described herein can comprise a method, which can include cyclizing a functionalized diol monomer with N,N′-carbonyldiimidazole, wherein the cyclizing produces a cyclic carbonate monomer and an imidazole carbamate. The method can also include activating the imidazole carbamate with an acid, wherein the activating promotes cyclization of the imidazole carbamate into the cyclic carbonate monomer.