CAS: 4358-87-6; Methyl 2-Hydroxy-2-Phenylacetate

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CAS号15206-55-0 苯甲酰甲酸甲酯 | CAS号124-38-9 二氧化碳 | CAS号53172-92-2 α-trimethylsily... | CAS号18107-18-1 (三甲硅烷)重氮甲烷 | CAS号67-56-1 甲醇 | CAS号611-71-2 扁桃酸 | CAS号104-53-0 3-苯丙醛 | CAS号122-78-1 2-苯基乙醛 | CAS号1074-12-0 苯基丙醇水合物 | CAS号2819-08-1 mixed anhydride... | CAS号4410-31-5 2-羟基-2-苯基乙酰胺 | CAS号451-40-1 二苯乙酮 | CAS号515-30-0 苯乳酸水合物 | CAS号15206-55-0 苯甲酰甲酸甲酯 | CAS号939-55-9 苯甲酸-2-氯乙酯 | CAS号4335-77-7 2-环己基-2-羟基苯乙酸 | CAS号2292-53-7 2,N-二羟基-2-苯乙酰胺 | CAS号611-71-2 扁桃酸 | CAS号20907-13-5 1,2-Propanediol... | CAS号19020-59-8 2,3-Diphenylbut...

D-扁桃酸 以 乙醚 作为反应溶剂,化学反应生成 Dl-扁桃酸甲酯
参考文献:Optically Pure 4-Aryl-2-Hydroxytetronic Acids
标题:Optically Pure 4-Aryl-2-Hydroxytetronic Acids
摘要:本发明涉及一种从光学纯醛合成光学纯立体不稳定4-芳基-2-羟基丁酸的方法.本发明进一步涉及将这种光学纯化合物作为通过在环氧合酶水平上作用以及作为环氧合酶和5-脂氧合酶的抑制剂来用作强力血小板聚集抑制剂的应用.本发明还涉及将这种化合物用于治疗冠状动脉疾病,特别是在治疗和/或预防动脉粥样硬化以及在治疗各种炎症病理学,特别是关节炎的药物应用.

专利信息

专利号:US-11370736-B2
优先权日:2019-04-01
标 题:Synthesis of fluoro hemiacetals via transition metal-catalyzed fluoro ester and carboxamide hydrogenation
发明人：DUB PAVEL A; BATRICE RAMI J; GORDON JOHN C
权利人:TRIAD NAT SECURITY LLC
摘要:This application is directed to use of transition metal-ligand complexes to hydrogenate fluorinated esters and carboxamides into fluorinated hemiacetals. Methods for synthesis of certain ligands are also provided.

专利号:US-5399721-A
优先权日:1990-01-12
标题:Synthesis of optically pure 4-aryl-2-hydroxytetronic acids
发明人：HOPPER ALLEN T; WITIAK DONALD T
权利人:UNIV OHIO STATE RES FOUND
摘要:The present invention relates to a method for synthesis of optically pure stereogenically labile 4-aryl-2-hydroxytetronic acids from an optically pure aldehyde. The invention further relates to the use of such optically pure compounds as potent inhibitors of platelet aggregation by working at the level of cyclooxygenase. the invention further relates to the pharmaceutical use of such compounds in the treatment of coronary artery diseases, especially in the treatment and/or prevention of atherosclerosis.

专利号:US-5656662-A
优先权日:1990-01-12
标 题:Synthesis of optically pure 4-alkenyl- or 4-alkanyl-2-hydroxytetronic acids
发明人：MANTRI PADMAJA; WITIAK DONALD T
权利人:UNIV OHIO STATE RES FOUND
摘要:The present invention relates to a method for synthesis of optically pure 4-alkenyl or 4-alkanyl-2-hydroxytetronic acids from an optically pure aldehyde. The invention further relates to the use of such optically pure compounds as potent inhibitors of platelet aggregation by working at the level of cyclooxygenase, thus making them useful in the treatment of coronary artery diseases, especially atherosclerosis, and additionally, as inhibitors of various inflammatory cytokines, making them useful in the treatment of both acute and chronic inflammation, as well in the treatment of cachexia, rheumatoid arthritis, multiple sclerosis, Crohn's disease and ulcerative colitis. The invention further relates to pharmaceutical compositions of the instant compounds.

专利号:US-6384228-B2
优先权日:1998-05-26
标题 :Method for synthesis of halopyridyl-azacyclopentane derivative and intermediate thereof
发明人：NODE MANABU; NAKAMURA DAISAKU; FUJIWARA TOSHIO; ICHIHASHI SHOGO
权利人:NIHON MEDIPHYSICS CO LTD
摘要:The present invention relates to a method for synthesis of an optically active halopyridyl-azacyclo-pentane derivative and the intermediate thereof which comprises preparing an optically active allene-1,3-dicarboxylic acid ester derivative from an optically active acetonedicarboxylic acid ester derivative and then proceeding through a 7-azabicyclo[2.2.1]heptane derivative to obtain the objective product.

专利号:US-6469133-B2
优先权日:1999-12-13
标题 :Process for the preparation of polymers of dimeric cyclic esters
发明人：BAKER GREGORY L; SMITH III MILTON R
权利人:UNIV MICHIGAN STATE
摘要:The present invention provides a process for the direct synthesis of high melting polymers made from dimeric cyclic esters. In particular, the present invention provides a process for synthesis of polylactic acid (PLA) from racemic materials such as racemic lactide and polymandelide from mandelide. The process further provides racemic metal organic ligand catalysts such as racemic salbinap that catalyzes the polymerization of racemic dimeric cyclic ester monomers to a polylactide stereocomplex. Polymandelide and mixed dimeric cyclic esters are also prepared in the presence of low amounts of water.

专利号:US-7462738-B2
优先权日:2006-05-24
标题:Processes for the preparation of R-(+)-3-(carbamoyl methyl)-5-methylhexanoic acid and salts thereof
发明人：HEDVATI LILACH; GILBOA EYAL; AVHAR-MAYDAN SHARON
权利人:TEVA PHARMA
摘要:Provided are processes for the synthesis of R-(+)-3-(carbamoylmethyl)-5-methylhexanoic acid and salts thereof, intermediates in the synthesis of S-pregabalin.