CAS: 4298-08-2; (2S,3S)-3-Hydroxypyrrolidine-2-Carboxylic Acid

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(2R,3S)-3-[tert-Butyl(Dimethyl)Silyl]Oxy-1-Prop-2-Enylpyrrolidine-2-Carbonitrile置于盐酸,氢氧化钾,Amberlyst 15,硫代水杨酸,1,4-双(二苯基膦)丁烷,Bis(Dibenzylideneacetone)-Palladium(0)体系中,用 四氢呋喃,甲醇,水 作为反应溶剂,化学反应生成 反-3-羟基-L-脯氨酸
参考文献:Reductive Cyanation: A Key Step For A Short Synthesis Of (−)-(2S,3S)-3-Hydroxyproline
标题:Reductive Cyanation: A Key Step For A Short Synthesis Of (−)-(2S,3S)-3-Hydroxyproline
摘要:A Short Stereoselective Synthesis Of (-)-(2S,3S)-3-Hydroxyproline Has Been Realized From L-Malic Acid As The Source Of Chirality. The Key Step Was The Reductive Cyanation Of The Intermediate La,In High Stereoselectivity And Yield. (C) 1998 Published By Elsevier Science Ltd. All Rights Reserved.
DOI:10.1016/s0040-4039(98)01133-2

专利信息

专利号:US-9475837-B2
优先权日:2011-12-23
标题 :Process for the synthesis of therapeutic peptides
发明人：HURLEY FIONN; WEGNER KATARZYNA; FOLEY PATRICK
权利人:IPSEN MFG IRELAND LTD
摘要:The present invention relates to a process for the large-scale synthesis of therapeutic peptides using a Sieber Amide resin, which comprises solid-phase Fmoc-chemistry.

专利号:US-2017349928-A1
优先权日:2014-12-31
标 题:Methods for activating natural energy metabolism for improving yeast cell-free protein synthesis
发明人：JEWETT MICHAEL CHRISTOPHER; ANDERSON MARK J; STARK JESSICA CAROL; HODGMAN CHARLES ERIC
权利人:UNIV NORTHWESTERN
摘要:Disclosed are compositions, methods, and kits for enhanced synthesis of a biological macromolecule in vitro using cell-free protein synthesis. The compositions, methods, and kits include or utilize: a cell-free extract; a phosphate-free energy source; and a phosphate source, and typically do not include an exogenous nucleoside triphosphate or an exogenous nucleoside diphosphate.

专利号:US-2005186197-A1
优先权日:2002-08-29
标 题:Peptide inhibitors of beta lactamases
发明人：PALZKILL TIMOTHY; HUANG WANZHI
摘要:Peptide inhibitors of β-lactamases have been identified by the synthesis of peptide arrays using synthesis SPOT technology. These peptide inhibitors of β-lactamase have activity against a broad spectrum of β-lactamases and are useful in a variety of applications.

专利号:US-2009017161-A1
优先权日:2006-02-28
标 题 :Gene encoding protein having trehalose synthesis-promoting activity and use thereof
发明人：NAKAO YOSHIHIRO; KODAMA YUKIKO; SHIMONAGA TOMOKO
权利人:SUNTORY LTD
摘要:The present invention relates to a gene encoding a protein having a trehalose synthesis-promoting activity and use thereof, in particular, a yeast for practical use with superior resistance property to dryness and/or low-temperature storage, alcoholic beverages produced with said yeast, and a method for producing said beverages. More particularly, the present invention relates to a yeast, whose resistance property to dryness and/or resistance property to low-temperature storage is enhanced by amplifying expression level of TSL1 gene encoding a protein Ts11p having a trehalose synthesis-promoting activity in brewer's yeast, especially non-ScTSL1 gene specific to a lager brewing yeast and to a method for producing alcoholic beverages with said yeast, etc.

专利号:US-12157908-B2
优先权日:2019-02-25
标 题:Cell-free protein synthesis platforms derived from clostridia extracts
发明人：JEWETT MICHAEL CHRISTOPHER; KRUGER-GERICKE ANTJE; MUELLER ALEXANDER PAUL; KOEPKE MICHAEL
权利人:UNIV NORTHWESTERN; LANZATECH INC
摘要:Disclosed are compositions, methods, and kits for performing cell-free RNA transcription and/or cell-free protein synthesis (CFPS). The disclosed compositions, methods, and kits include or utilize components prepared from a species of Clostridia such as cellular extracts from Clostridium autoethanogenum.

专利号:US-2005208121-A1
优先权日:2000-11-30
标题 :Polymeric cannulae proteins, nucleic acids encoding them and methods for making and using them
发明人：BARTON NELSON R; O'DONOGHUE EILEEN; FREY GERHARD; SHORT JAY M; LAFFERTY W M; CHOW KEVIN
权利人:BARTON NELSON R; O'DONOGHUE EILEEN; FREY GERHARD; SHORT JAY M; LAFFERTY W M; CHOW KEVIN
摘要:The invention provides chimeric cannulae polypeptides and methods for making and using them. In one aspect, the invention provides compositions and methods for the identification, separation or synthesis of proteins or ligands. In one aspect, the invention provides compositions and methods for making and using nanotubules. In one aspect, the invention provides compositions and methods for the selection and purification of chiral compositions from racemic mixtures. The invention provides compositions comprising polymers prepared by self-assembly of a plurality of monomeric polypeptide units, including nanorobots, biochips, drug delivery systems. In one aspect, the polymer can form a nanotube, and the polymer (nanotubule) can encapsulate a drug molecule—a drug delivery systems of the invention. A drug delivery system of the invention may be delivered to a particular location of human body to effectively cure a disease or treat a symptom. In one aspect, a targeting vector can be attached to a monomeric polypeptide unit or a polymer to facilitate the targeting of the drug delivery system of the invention.