CAS: 38053-91-7; (Buta-1,3-Dien-2-Yloxy)Trimethylsilane

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CAS号75-77-4 三甲基氯硅烷 | CAS号78-94-4 丁烯酮 | CAS号27607-77-8 三氟甲磺酸三甲基硅酯 | CAS号83313-71-7 ((1-((1R,2R,4R)... | CAS号108161-83-7 (4-iodobut-2-en... | CAS号25561-30-2 N,O-双(三甲基硅烷基)三氟乙酰胺 | CAS号585-36-4 3-(三氟甲基)环己酮 | CAS号75091-99-5 4-三氟甲基环己烷-1-酮 | CAS号194979-79-8 1,2,4,4a,5,6-he... | CAS号81357-18-8 4-氧代-1,2-哌啶二羧酸 ... | CAS号6297-22-9 4-环己酮羧酸甲酯 | CAS号170304-68-4 4-羟基-[1,1-联苯]-2-羧酸甲酯 | CAS号104331-18-2 ethyl 4-ox°Cycl... | CAS号67311-98-2 ethyl 4-ox°Cycl... | CAS号54584-38-2 methyl 1,4-diox...

丁烯酮 反应生成2-三甲基硅氧基-1,3-丁二烯
参考文献:Cyclocondensation Adducts From The Lewis Acid Mediated Reaction Of 4-Acetoxy-2-Azetidinone With Siloxydienes
标题:Cyclocondensation Adducts From The Lewis Acid Mediated Reaction Of 4-Acetoxy-2-Azetidinone With Siloxydienes
摘要:
Doi:10.1016/s0040-4039(01)84585-8

专利信息

专利号:US-7276637-B2
优先权日:2002-08-02
标题:Synthesis of cyclohexanone derivatives
发明人：BRANDS KAREL MARIE JOSEPH; DAVIES ANTONY JOHN; OAKLEY PAUL JOSEPH; SCOTT JEREMY PETER; SHAW DUNCAN EDWARD; TEALL MARTIN RICHARD
权利人:MERCK & CO INC
摘要:A novel process for preparing cyclohexanone derivatives of formula (I) n nis described. The products are useful as gamma secretase inhibitors, or as intermediates in the synthesis of other gamma secretase inhibitors.

专利号:US-5097051-A
优先权日:1989-02-10
标题 :Cyclic triketone compounds and trimethylsilyloxy butadiene compounds and their use in the preparation of daunomycinone derivatives
发明人：SCHEEREN JOHAN W; DEBIE JOANNES F M; DEVOS DIRK
权利人:PHARMACHEMIE BV
摘要:The invention provides novel cyclic triketone compounds of the formulae wherein S is H, alkyl or alkoxy and R* is a group of the formule wherein R<1> is methyl and R2 is an alkyl group containing at least 2 carbon atoms, or R<1> is an alkyl group having 1-4 carbon atoms and R<2> is an aryl group, a hetero aryl group, a -CH2OR min , a -CH2N @@ group, a -CH2SR sec group or a -CH2CH=CH2 group, wherein R min and R sec are alkyl groups having 1-4 carbon atoms. These compounds can be used for preparing daunomycinone and derivatives thereof. Daunomycinone is used for preparing daunomycin and adriamycin. By introducing chirality at C-1 of ring A in the preparation of said novel compounds by using a novel diene of formula (1) in a Diels-Alder reaction for said preparation, the chirality of C-3 is established in the subsequent reaction with LiC IDENTICAL CSi(CH3)3 in the synthesis of daunomycinone and derivatives thereof. This last reaction leads to the desired compound wherein OH at C-3 and OR at C-1 are in the cis-position with respect to each other.

专利号:US-5183913-A
优先权日:1989-02-10
标 题 :Cyclic triketone compounds and trimethylsilyoxy butadiene compounds and their use in the preparation of daunomycinone derivatives
发明人：SCHEEREN JOHAN W; MARTINUS DE BIE JOANNES F; DE VOS DIRK
权利人:PHARMACHEMIE BV
摘要:The invention provides novel cyclic triketone compounds of the formulae (2) (3) wherein S is H, alkyl or alkoxy and R* is a group of the formule wherein R1 is methyl and R2 is an alkyl group containing at least 2 carbon atoms or R1 is an alkyl group having 1-4 carbon atoms and R2 is an aryl group, a hetero aryl group, a -CH2OR' group, a -CH2N (1) This last reaction leads to the desired compound wherein OH at C-3 and OR at C-1 are in the cis-position with respect to each other.

专利号:US-2005222456-A1
优先权日:2002-08-02
标 题:Synthesis of cyclohexanone derivatives

专利号:WO-2004013090-A1
优先权日:2002-08-02
标题 :Synthesis of cyclohexanone derivatives

专利号:US-2012295923-A1
优先权日:2010-01-29
标 题:Aminocyclohexanes and Aminotetrahydropyrans and Related Compounds As Gamma-Secretase Modulators
发明人：AM ENDE CHRISTOPHER WILLIAM; FISH BENJAMIN ADAM; JOHNSON DOUGLAS SCOTT; LIRA RICARDO; O'DONNELL CHRISTOPHER JOHN; PETTERSSON MARTIN YOUNGJIN; STIFF COREY MICHAEL
权利人:AM ENDE CHRISTOPHER WILLIAM; FISH BENJAMIN ADAM; JOHNSON DOUGLAS SCOTT; LIRA RICARDO; O'DONNELL CHRISTOPHER JOHN; PETTERSSON MARTIN YOUNGJIN; STIFF COREY MICHAEL; PFIZER
摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I n n n n n n n n n n as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.