专利号:WO-2013057110-A1 优先权日:2011-10-19 标 题:Method for the synthesis of citric acid esters 发明人:ALTENBACH HANS-JOSEF; LANGE KARSTEN; NANDI SUKHENDU; IHIZANE RACHID; JAKOB BERND; SCHNEIDER MANFRED 权利人:BERGISCHE UNI WUPPERTAL; ALTENBACH HANS-JOSEF; LANGE KARSTEN; NANDI SUKHENDU; IHIZANE RACHID; JAKOB BERND; SCHNEIDER MANFRED 摘要:The present invention discloses a targeted synthesis method for the synthesis of asymmetric monoesters and/or symmetrical diesters of citric acid through acidic esterification by using boric acid or a boronic acid as a catalyst. The boric/boronic acid simultaneously acts as a catalyst, as well as a 'protecting group' for the tertiary carboxylic acid, and therefore specifically only the asymmetric monoesters or symmetrical diesters are created.
专利号:US-7652137-B2 优先权日:2003-03-06 标 题:Synthesis of 5 substituted 7-azaindoles and 7-azaindolines 发明人:GRACZYK PIOTR PAWEL; KHAN AFZAL; BHATIA GURPREET SINGH 权利人:EISAI R&D MAN CO LTD 摘要:The present invention provides a novel substituted azaindoline intermediate of formula (I) and a method for its synthesis. The novel substitued azaindoline intermediate (I) is provided for use in the manufacture of 5-substituted 7-azaindolines and 5-substituted 7-azaindoles.
专利号:US-9611281-B2 优先权日:2013-12-05 标题:BODIPY derivatives and methods of synthesis and use thereof 发明人:YOU YOUNGJAE; AWUAH SAMUEL; WATLEY RYAN 权利人:UNIV OKLAHOMA 摘要:Derivatives of BODIPY (boron dipyrromethene difluoride) and their synthesis and use are disclosed.
专利号:ES-2355726-T3 优先权日:2003-03-06 标题:SYNTHESIS OF 7-AZAINDOLES AND 7-AZAINDOLINAS REPLACED IN POSITION 5.
专利号:DE-102011054602-A1 优先权日:2011-10-19 标 题 :Process for the synthesis of citric acid esters
专利号:EP-1633750-A2 优先权日:2003-03-06 标 题 :Synthesis of 5-substituted 7-azaindoles and 7-azaindolines
[参考文献]: Feng Cai, Et Al. Chiral Allene-Containing Phosphines In Asymmetric Catalysis. J Am Chem Soc. 2011 Nov 16;133(45):18066-9. [参考文献]: Mamoru Tobisu, Et Al. Nickel-Catalyzed Suzuki-Miyaura Reaction Of Aryl Fluorides. J Am Chem Soc. 2011 Dec 7;133(48):19505-11. [参考文献]: Sylvain Achelle, Et Al. Synthesis And Photophysical Investigation Of A Series Of Push-Pull Arylvinyldiazine Chromophores. J Org Chem. 2012 Apr 20;77(8):4087-96.
合成参考文献
摘要:von Angerer, S., Science of Synthesis Knowledge Updates, (2011) 1, 376. 摘要:Rodríguez-Morgade, M. S.; Torres, T., Science of Synthesis Knowledge Updates, (2017) 2, 146. 摘要:Kawęcki, R., Science of Synthesis Knowledge Updates, (2018) 4, 257. 摘要:Guram, A. S.; Milne, J. E.; Tedrow, J. S.; Walker, S. D., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 1, 50. 摘要:Guram, A. S.; Milne, J. E.; Tedrow, J. S.; Walker, S. D., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 1, 22.