CAS: 218949-48-5; Tesamorelin

该化合物是一个新的生长激素释放因子类似,不仅可以恢复身体正常生长激素分泌,还可以减少内脏脂肪组织增加,改善血液脂异常和生活质量,保持体内葡萄糖原体保持.

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      专利号:US-2020354404-A1
      优先权日:2019-05-09
      标 题 :Peptidomimetic agents, synthesis and uses thereof
      发明人：AL-ABED YOUSEF
      权利人:FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
      摘要:Compounds for use in synthesis of peptidomimetic agents; synthesis of peptidomimetic agents; peptidomimetic diagnostic and therapeutic agents; and uses of the compounds and peptidomimetic agents in drug discovery, diagnosis, prevention and treatment of diseases are described.

      专利号:US-10919882-B2
      优先权日:2019-05-09
      标题:Compounds for use in synthesis of peptidomimetics

      专利号:US-11414405-B2
      优先权日:2019-05-09
      标 题:Compounds for use in synthesis of peptidomimetics

      专利号:AU-2020409711-A1
      优先权日:2019-12-20
      标题 :Synthesis of lactone derivatives and their use in the modification of proteins

      专利号:EP-4076533-A1
      优先权日:2019-12-20
      标 题:Synthesis of lactone derivatives and their use in the modification of proteins

      专利号:EP-3965770-A1
      优先权日:2019-05-09
      标 题 :Compounds for use in synthesis of peptidomimetics

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      合成参考文献


      摘要:O'Neal R. Tesamorelin update. BETA. 2010 Jun;22(4):16–9.
      参考文献:10.1371/journal.pone.0140358
      摘要:Mangili A, Falutz J, Mamputu J, Stepanians M, Hayward B. Predictors of Treatment Response to Tesamorelin, a Growth Hormone-Releasing Factor Analog, in HIV-Infected Patients with Excess Abdominal Fat. PLoS ONE. 2015 Oct 12;10(10):e0140358. doi: 10.1371/journal.pone.0140358.
      参考文献:10.14283/jfa.2018.45
      摘要:Adrian S, Scherzinger A, Sanyal A, Lake JE, Falutz J, Dubé MP, Stanley T, Grinspoon S, Mamputu J-, Marsolais C, Brown TT, Erlandson KM. The Growth Hormone Releasing Hormone Analogue, Tesamorelin, Decreases Muscle Fat and Increases Muscle Area in Adults with HIV. The Journal of Frailty & Aging. 2018 Dec 14;8(3):154–9. doi: 10.14283/jfa.2018.45.
      参考文献:10.1038/s41380-021-01228-5
      摘要:Recinella L, Chiavaroli A, Orlando G, Ferrante C, Veschi S, Cama A, Marconi GD, Diomede F, Gesmundo I, Granata R, Cai R, Sha W, Schally AV, Brunetti L, Leone S. Effects of growth hormone-releasing hormone receptor antagonist MIA-602 in mice with emotional disorders: a potential treatment for PTSD. Mol Psychiatry. 2021 Dec;26(12):7465–74. doi: 10.1038/s41380-021-01228-5.
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