CAS: 202917-05-3; 6,7-Dimethoxy-4-(3-Nitrophenoxy)Quinoline (Cabozantinib Impurity)

英文名称6,7-Dimethoxy-4-(3-Nitrophenoxy)Quinoline (Cabozantinib Impurity)
中文名称6,7-二甲氧基-4-(3-硝基苯氧基)喹啉 (卡博替尼杂质)
CAS编号202917-05-3
分子式:C17H14N2O5分子量:326.3
产品CID: 1030036
产品分类有机原料→分子砌块→芳杂环类化合物→喹啉类化合物

相似结构搜索
InChIKey: OMYGYNKHKZLDSH-UHFFFAOYSA-N
1S/C17H14N2O5/c1-22-16-9-13-14(10-17(16)23-2)18-7-6-15(13)24-12-5-3-4-11(8-12)19(20)21/h3-10H,1-2H3
计算化学: 氢键受体数6.0氢键供体数*可旋转键数4.0

相似化合物

190728-25-7 190728-25-7 202917-04-2

MSDS等安全信息

上下游产品

6,7-dimethoxy-4-chloroquinoline meta-nitrophenol ethyl 6,7-dimethoxy-4-oxo-1,4-dihydro-3-quinolinecarboxylate 1,4-dihydro-6,7-dimethoxy-4-oxoquinoline

合成工艺路线路线简述

📜4-羟基-6,7-二甲氧基喹啉置于三氯氧磷体系中,用二乙二醇二甲醚用作溶剂,化学反应生成卡博替尼杂质50
参考文献:A Novel Series Of 4-Phenoxyquinolines: Potent And Highly Selective Inhibitors Of Pdgf Receptor Autophosphorylation
标题:A Novel Series Of 4-Phenoxyquinolines: Potent And Highly Selective Inhibitors Of Pdgf Receptor Autophosphorylation
摘要:A Novel Series Of 4-Phenoxyquinolines,Some Of Which Showed Potent And Highly Selective Inhibitory Activities For Pdgf Receptor Autophosphorylation,Was Discovered. Interestingly,Their Structures Were Very Similar To Those Of The Selective Inhibitors For Egf Receptor Autophosphorylation. (C) 1997 Elsevier Science Ltd.
Doi:10.1016/s0960-894X(97)10117-2