CAS: 182868-72-0; 1-Cyclopropyl-8-Ethoxy-6-Fluoro-7-(3-Methylpiperazin-1-yl)-4-Oxo-1,4-Dihydroquinoline-3-Carboxylic Acid

相似化合物

614751-80-3 1029364-65-5 1048972-28-6

📜1-环丙基-6,7-二氟-1,4-二氢-8-乙氧基-4-氧代-3-喹啉羧酸,2-甲基哌嗪 反应 2.0H,以50%的收率获得1-环丙基-8-乙氧基-6-氟-7-(3-甲基哌嗪-1-基)-4-氧代-1,4-二氢喹啉-3-羧酸
参考文献:Synthesis Of Norfloxacin Analogues Catalyzed By Lewis And Brönsted Acids: An Alternative Pathway
标题:Synthesis Of Norfloxacin Analogues Catalyzed By Lewis And Brönsted Acids: An Alternative Pathway
摘要:An Alternative Synthetic Pathway To Prepare Norfloxacin Analogues Is Presented. Three Lewis Acids (Cecl3 Center Dot 7H(2)O,Alcl3 Center Dot 6H(2)O,Zncl2) And One Bronsted Acid (Tsoh) Were Tested As Catalysts In The Preparation Of 3,4-Difluoroacrylate. Cyclization Of This Acrylate At 55 Degrees C Was Achieved With The Use Of Eaton'S Reagent (P2O5/meso3H) A Known Bronsted Acid. The Fluoroquinolone-Boron Complex Presented High Yields On C-7 Nucleophilic Substitution Of The Fluorine Atom By Different Heterocyclic Amines With Low,Medium And Strong Nucleophilic Character. (C) 2010 Elsevier B.V. All Rights Reserved.
Doi:10.1016/j.Jfluchem.2010.07.002