CAS: 154924-17-1; 6-(Dimethylamino)Nicotinonitrile
该化合物是一种多用途的七环化合物,在6位置以二甲基氨基组替换一对丙烯核,在3位置以一对硝三联苯组取代一对丙烯基,这种结构具有独特的电子和消毒特性,使其成为有机合成和制药研究的宝贵中间体.二甲基氨基组会提高电子密度,促进核生殖反应,而硝酸三联苯功能则为进一步衍生提供再活动.其定义明确的分子框架有利于在化学协调中构建复杂的乙基循环或离子.该化合物在普通有机溶剂中的稳定性和溶性进一步支持其在多种合成应用中的用途.
- 英文名称6-(Dimethylamino)Nicotinonitrile
- 中文名称6-(二甲氨基)烟腈
- IUPAC名称6-(dimethylamino)nicotinonitrile
- 其它别名6-(二甲胺基)-3-氰基吡啶; 6-(Dimethylamino)Pyridine-3-Carbonitrile
- CAS编号154924-17-1
- MFCD编号:MFCD08272099
- 分子式:C8H9N3分子量:147.18
- 产品CID: 765942
- 产品分类有机原料→分子砌块→芳杂环类化合物→吡啶类化合物
相似化合物
82846-28-4 149805-92-5 261715-36-0物理性质
MSDS等安全信息
上下游产品
6-chloronicotinonitrile dimethyl amine 5-bromo-2-dimethylaminopyridine ethyl 2-cyanoacetate 5-(aminomethyl)-N,N-dimethylpyridin-2-amine [1,2,4]triazolo[1,5-a]pyridin-6-ylmethanamine [1,2,4]triazolo[1,5-a]pyridine-6-carbonitrile 6-(dimethylamino)nicotine-3-carboxaldehyde合成工艺路线路线简述
📜2-氨基-5-氰基吡啶,N,N-二甲基甲酰胺二甲基缩醛 以 N,N-二甲基甲酰胺 用作溶剂,化学反应生成6-(二甲胺基)-3-氰基吡啶
参考文献:Discovery Of (S)-1-(1-(Imidazo[1,2-A]Pyridin-6-yl)Ethyl)-6-(1-Methyl-1H-Pyrazol-4-yl)-1H-[1,2,3]Triazolo[4,5-B]Pyrazine (Volitinib) As A Highly Potent And Selective Mesenchymal-epithelial Transition Factor (C-Met) Inhibitor In Clinical Development For Treatment Of Cancer
标题:Discovery Of (S)-1-(1-(Imidazo[1,2-A]Pyridin-6-yl)Ethyl)-6-(1-Methyl-1H-Pyrazol-4-yl)-1H-[1,2,3]Triazolo[4,5-B]Pyrazine (Volitinib) As A Highly Potent And Selective Mesenchymal-epithelial Transition Factor (C-Met) Inhibitor In Clinical Development For Treatment Of Cancer
摘要:Hgf/c-Met Signaling Has Been Implicated In Human Cancers. Herein We Describe The Invention Of A Series Of Novel Triazolopyrazine C-Met Inhibitors. The Structure Activity Relationship Of These Compounds Was Investigated,Leading To The Identification Of Compound 28,Which Demonstrated Favorable Pharmacokinetic Properties In Mice And Good Antitumor Activities In The Human Glioma Xenograft Model In Athymic Nude Mice.
Doi:10.1021/jm500510F
海关参考信息
- 2933310010-吡啶
2926909090-其他腈基化合物
2921199090-其他无环单胺
2939800000-其他生物碱 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-11279687-B2
优先权日:2010-09-03
标题:Compounds and compositions for the inhibition of NAMPT
发明人：BAIR KENNETH W; BAUMEISTER TIMM R; BUCKMELTER ALEXANDRE J; CLODFELTER KARL H; HAN BINGSONG; LIN JIAN; REYNOLDS DOMINIC J; SMITH CHASE C; WANG ZHONGGUO; ZHENG XIAOZHANG; YUEN PO-WAI
权利人:VALO HEALTH INC; GENENTECH INC
摘要:The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An embodiment of the invention is the provision of a compound of Formula IIIA.
