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专利信息

专利号:US-2022098155-A1
优先权日:2018-11-14
标 题 :Novel pathway for the synthesis of diazirines, that may or may not be enriched in nitrogen-15
发明人：REBOUL VINCENT; FRANCK XAVIER; GLACHET THOMAS; MARZAG HAMID
权利人:UNIV ROUEN NORMANDIE; UNIV CAEN; INSTITUT NAT DES SCIENCES APPLIQUEES DE ROUEN INSA; CENTRE NAT RECH SCIENT; ECOLE NAT SUPERIEURE DINGENIEURS DE CAEN
摘要:The present invention concerns a novel method for synthesising diazirines, that may or may not be enriched in nitro-gen-15, from amino acids or imines, via a one-pot synthesis method, comprising the reaction of the starting amino acid or imine with ammonia, which may or may not be enriched in nitrogen-15, and a hypervalent iodine oxidant. The present invention also relates to a method for synthesising ammonia enriched in nitrogen-15. The invention also concerns certain diazirines of formula (I) likely to be obtained by the claimed synthesis method, and also refers to the 15 N 2 -diazirines of formula (I′). The claimed diazirines can be used in photoaffinity labelling. The 15 N 2 -diazirines can also be used in hyperpolarisation, in particular in the medical imaging field.

专利号:US-2012196989-A1
优先权日:2005-02-11
标题:Synthesis of homopolymers and block copolymers
发明人：BREITENKAMP KURT; SILL KEVIN N
权利人:BREITENKAMP KURT; SILL KEVIN N; INTEZYNE TECHNOLOGIES INC
摘要:The present invention relates to the field of polymer chemistry and more particularly to homopolymers and block copolymers and methods of preparing the same.

专利号:US-7799524-B2
优先权日:2002-10-03
标 题:Substrates for O6-alkylguanina-DNA alkyltransferase
发明人：KINDERMANN MAIK; JOHNSSON KAI; BIERI CHRISTOPH
权利人:ECOLE POLYTECHNIQUE FERDEALE D
摘要:The invention relates to compounds of formula 1 n nwherein R 1 -R 2 is a guanine derivative; X is oxygen or sulfur; R 3 is a heteroaromatic, unsaturated heterocyclyl or an alkynyl group with the double or triple bond connected to CH 2 ; R 4 is a linker; and L is a label, a plurality of same or different labels, a bond connecting R 4 to R 1 forming a cyclic substrate, or a further group —R 3 —CH 2 —X—R 1 -R 2 . The invention relates also to methods of manufacture of such novel AGT substrates, to intermediates useful in the synthesis of such AGT substrates, and to a method of transferring a label from such AGT substrates to O 6 -alkylguanine-DNA alkyltransferase (AGT) fusion proteins comprising proteins of interest.

专利号:US-5175266-A
优先权日:1991-04-19
标 题 :Nucleosides and oligonucleosides with a phosphate-free internucleoside backbone and process for preparing the same
发明人：VARMA RAJENDER S; HOGAN MICHAEL E; REVANKAR GANAPATHI R; RAO TAKKELLAPATI S
权利人:TRIPLEX PHARMA CORP; BAYLOR COLLEGE MEDICINE
摘要:Nucleoside derivatives which contain a nucleo-base, a sugar and an amino acid backbone of the structure: ##STR1## where R' refers to the various amino acid side chains or their blocked equivalent and R refers to a nucleo-base or its blocked equivalent. The synthesis of these nucleoside derivatives proceeds by a series of steps including oxidation of the 3'-azido nucleoside derivative, coupling to a benzylated ester of an amino acid to yield the amide and hydrogenation. The adenine, guanine, cytosine and thymine nucleosides with an amino acid at the 5' terminus are synthesized. From such monomers oligonucleotides can be synthesized which possess an amino acid backbone, using either solid state phase chemistry or liquid phase chemistry.

专利号:ES-2402614-A1
优先权日:2011-10-24
标题:CONTROLLED SYNTHESIS OF POLYGLUTAMATES WITH LOW POLIDISPERSITY AND VERSATILE ARCHITECTURES

专利号:WO-2011075483-A1
优先权日:2009-12-16
标 题 :Controlled synthesis of polyglutamic acid