CAS: 122-16-7; N-(4-(N-(4-Nitrophenyl)Sulfamoyl)Phenyl)Acetamide

该化合物是一种以磺酰胺为基础的抗微生物剂,主要用于兽医学,用于预防和治疗家禽的共菌病,其化学结构允许有效抑制二氢乙酸合成中的一种关键酶二氢乙酸合成,从而扰乱了原生动物的生长;Sulfanitran由于稳定和统一的分布,经常通过饲料进行控制;该复合物展示了针对Eimeria物种的广泛活动,有助于改善羊群的健康和生产力;其毒性低和与其他饲料添加剂的兼容性使得它成为综合疾病管理方案的一个实际选择;适当的剂量和提取期对于确保监管合规和避免残留至关重要.

结构式图片

上下游产品

4-nitro-aniline p-acetylaminobenzenesulfonyl chloride para-dinitrobenzene (4-acetylaminophenyl)boronic acid4-amino-N-(4-nitrophenyl)-benzenesulfonamide N-acetyl-sulfanilic acid-(4-amino-anilide)N-acetyl-sulfanilic acid-(4-amino-anilide) p-aminobenzenesulphonamido-4-aniline N-acetyl-sulfanilic acid-(4-acetylamino-anilide)N-acetyl-sulfanilic acid-(4-acetylamino-anilide)

合成工艺路线路线简述

    📜N-{4-[(4-Iodophenyl)Sulfamoyl]Phenyl}Acetamide置于1,10-菲罗啉,Iron(II) Sulfate,Potassium Nitrate体系中,用 二甲基亚砜 用作溶剂,化学反应 48.0H,以54%的收率获得磺胺硝苯
    参考文献:通过单电子转移对芳基卤化物进行光诱导铁催化ipso硝化
    标题:通过单电子转移对芳基卤化物进行光诱导铁催化ipso硝化
    摘要:光致铁-催化的本位与kno芳基卤化物的-Nitration 2已经被开发出来,其中的芳基碘化物,溴化物和某些芳基氯化物的是可行的.机理研究表明,Feso 4,Kno 2和1,10-菲咯啉原位形成的铁络合物作为捕光光催化剂,激发态寿命更长,反应发生光诱导单电子转移(Set) 过程.这项工作代表了光诱导铁催化的 Ullmann 型耦合的一个例子.
    Doi:10.1021/acscatal.1C02272

    海关参考信息

    专利信息


    专利号:US-9693999-B2
    优先权日:2011-01-26
    标题:Small molecule RNase inhibitors and methods of use
    发明人:DUNMAN PAUL M; OLSON PATRICK D; CHILDERS WAYNE
    权利人:UNIV ROCHESTER; UNIV NEBRASKA; Temple University—Of the Commonwealth System of Higher Education
    摘要:Small molecule inhibitors of bacterial ribonuclease (e.g., RnpA) and methods for their synthesis and use are described herein. The methods of using the compounds include treating and preventing microbial infections and inhibiting bacterial ribonuclease. Also described herein are methods of identifying compounds for treating or preventing a microbial infection.

    专利号:US-9439423-B2
    优先权日:2007-10-29
    标 题 :Antiparasitic agent for fish and method of controlling proliferation of fish parasites
    发明人:KAWANO FUMI; HIRAZAWA NORITAKA
    权利人:KAWANO FUMI; HIRAZAWA NORITAKA; NIPPON SUISAN KAISHA LTD
    摘要:An antiparasitic agent for fish includes an inhibitor of folate synthesis and/or an inhibitor of folate activation as the active substance(s). A combination preparation composed of an inhibitor of folate synthesis and an inhibitor of folate activation is disclosed. Sulfonamide is disclosed as suitable for the inhibitor of folate synthesis. A dihydrofolate reductase inhibitor, a folate antagonist are disclosed as suitable inhibitors of folate activation. The antiparasitic agent is able to exterminate fish parasites via oral administration. It is effective against fish parasites belonging to the ciliate group.

    专利号:US-9265777-B2
    优先权日:2009-04-27
    标题 :Antiparasitic agent for fish and method of controlling proliferation of fish parasites
    发明人:KAWANO FUMI; HIRAZAWA NORITAKA
    权利人:KAWANO FUMI; HIRAZAWA NORITAKA; NIPPON SUISAN KAISHA LTD
    摘要:A method of controlling proliferation of fish parasites comprising the administration of 1 to 50 mg/kg fish body weight/day of an inhibitor of folate synthesis and/or an inhibitor of folate activation to fish continuously for 1 to 2 weeks. Using a combination preparation composed of an inhibitor of folate synthesis and an inhibitor of folate activation is preferable, and a sulfonamide is preferable for the inhibitor of folate synthesis. A dihydrofolate reductase inhibitor, a folate antagonist, etc., can be used as the inhibitor of folate activation. The antiparasitic agent is able to exterminate fish parasites via oral administration. It is particularly effective against parasites belonging to the ciliate group among fish parasites.

    专利号:WO-2009056955-A1
    优先权日:2007-10-30
    标题 :Amine-bearing phospholipids (abps), their synthesis and use
    发明人:ZUMBUEHL ANDREAS
    权利人:UNIV BASEL; ZUMBUEHL ANDREAS
    摘要:Disclosed herein are amine-bearing phospholipids (ABP). The ABPs display many properties and functionalities of naturally occurring phospholipids, but also new properties and functionalities, such as the ability to polymerize while maintaining structural integrity, that may supplement or expand the functionalities of naturally occurring phospholipids.

    专利号:US-9868747-B2
    优先权日:2014-02-18
    标题:Marinopyrrole derivatives and methods of making and using same
    发明人:LI RONGSHI; SEBTI SAID; LIU YAN; QIN YONG; SONG HAO; CHENG CHUNWEI
    权利人:H LEE MOFFITT CANCER CT & RES; CHONGQING ZEIN PHARMACEUTICAL CO LTD
    摘要:Marinopyrrole derivatives and methods for their synthesis and use are described herein. Novel cyclic and symmetric marinopyrroles with triazole substituents having antibacterial activity against resistant bacterial strains, such as MRSA are introduced. Also provided are methods of using the compounds for treating or preventing cancer and/or microbial infections.

    专利号:US-9907753-B2
    优先权日:2010-03-19
    标 题 :Lipid vesicle compositions and methods of use
    发明人:IRVINE DARRELL J; MOON JAEHYUN
    权利人:MASSACHUSETTS INST TECHNOLOGY
    摘要:The invention provides delivery systems comprised of stabilized multilamellar vesicles, as well as compositions, methods of synthesis, and methods of use thereof. The stabilized multilamellar vesicles may comprise prophylactic, therapeutic and/or diagnostic agents.

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    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献


    1: Eaves KL, Colvin BM, Hanks AR, Bushway RJ. High pressure liquid chromatographic determination of sulfanitran and dinsed in medicated feeds and premixes. J Assoc Off Anal Chem. 1977 Sep;60(5):1064-6. doi: 10.1016/j.ijpharm.2009.03.011. Epub 2009 Mar 19. Epub 2003 Apr 17. Chinese. doi: 10.1016/j.chroma.2008.05.095. Epub 2008 Jun 8. doi: 10.1124/dmd.107.019620. Epub 2008 Jan 7.

    合成参考文献


    摘要:S72 | NTUPHTW | Pharmaceutically Active Substances from National Taiwan University | DOI:10.5281/zenodo.3955664
    参考文献:10.1080/00034983.1996.11813090
    摘要:Woods KM, Nesterenko MV, Upton SJ. Efficacy of 101 antimicrobials and other agents on the development ofCryptosporidium parvum in vitro. Annals of Tropical Medicine & Parasitology. 1996 Jan;90(6):603–15. doi: 10.1080/00034983.1996.11813090.
    参考文献:10.1002/bies.10114
    摘要:Bermingham A, Derrick JP. The folic acid biosynthesis pathway in bacteria: evaluation of potential for antibacterial drug discovery. Bioessays. 2002 Jul;24(7):637–48. doi: 10.1002/bies.10114.
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