CAS: 1198-47-6; 6-(Methylthio)-7H-Purin-2-Amine

相似化合物

154-42-7 50-66-8 452-06-2

上下游产品

thioguanin dimethyl sulfate methyl iodide 6-thioguanine N6-phenethyl-7(9)H-purine-2,6-diyldiamineN6-phenethyl-7(9)H-purine-2,6-diyldiamine 2-Amino-6-dimethyl-amino-purin N6-butyl-7(9)H-purine-2,6-diyldiamineN6-butyl-7(9)H-purine-2,6-diyldiamine 6-methyl-2,6-diaminopurineN6-methyl-2,6-diaminopurine

📜6-Methylsulfanyl-Pyrimidine-2,4,5-Triamine 反应生成2-氨基-6-巯嘌呤
参考文献:O.Sup.6-Benzylated Guanine,Guanosine And 2'-Deoxyguanosine Compounds
标题:O.Sup.6-Benzylated Guanine,Guanosine And 2'-Deoxyguanosine Compounds
摘要:O.Sup.6-苄基化鸟嘌呤鸟苷和2'-脱氧鸟嘌呤鸟苷化合物的化学式为 ##str1## 其中z为氢,##str2## 而r为苄基或取代苄基,这些化合物会导致哺乳动物细胞中o.Sup.6-烷基鸟嘌呤-Dna烷基转移酶(agt)活性的耗竭.这些化合物可以被用于治疗多种肿瘤,通过将其注入到宿主体内以减少宿主体内肿瘤细胞中agt的水平,从而增加宿主体对抗肿瘤烷基化剂的反应性,包括氯乙基化剂,如氯乙基亚硝酰脲.

专利信息

专利号:US-7229797-B1
优先权日:1999-08-20
标 题:Enzymatic synthesis of deoxyribonucleosides
发明人：TISCHER WILHELM; IHLENFELDT HANS-GEORG; BARZU OCTAVIAN; SAKAMOTO HIROSHI; PISTOTNIK ELISABETH; MARLIERE PHILIPPE; POCHET SYLVIE
权利人:PASTEUR INSTITUT
摘要:The present invention relates to a method for the in vitro enzymatic synthesis of deoxyribonucleosides and enzymes suitable for this method.

专利号:EP-0590361-A1
优先权日:1992-09-17
标 题 :Process for the preparation of 2-amino-6-halopurines
发明人：HAGEN HELMUT DR; RAATZ PETER DR
权利人:BASF AG
摘要:Preparation of 2-amino-6-halopurines I (X = halogen) by hydrolysis of 2-acylamino-6-halopurines II (R¹, R² = acyl; R² = H) in the presence of an acid or base and preparation of II by acylation of guanine III to acylguanine Va or Vb and halogenation of V with a halogenating agent VI to II.n n n V and II are new intermediates for the synthesis of I when R1 and R2 are haloacetyl.

专利号:US-6018042-A
优先权日:1994-08-09
标题:Antitumor antisense oligonucleotides
发明人：METT HELMUT; HAENER ROBERT; DEAN NICHOLAS MARK
权利人:NOVARTIS AG
摘要:The invention relates to deoxyribo- and ribo-oligonucleotides and derivatives thereof, as well as pharmaceutical preparations, therapies, diagnostics and commercial research reagents in relation to disease states which respond to modulation of the synthesis of the enzyme S-adenosylmethionine decarboxylase (SAMDC). In particular, the invention relates to antisense oligonucleotides and oligonucleotide derivatives specifically hybridizable with nucleic acids relating to (preferably human) SAMDC. These oligonucleotides and their derivatives have been found to modulate the synthesis of SAMDC in cells.

专利号:US-5639867-A
优先权日:1993-09-17
标 题 :TTTr as protective group in nucleotide synthesis
发明人：BRILL WOLFGANG K-D
权利人:CIBA GEIGY CORP
摘要:The invention relates to nucleosides, nucleotides and oligonucleotides carrying in their basic structure a primary hydroxyl group protected by tris-4,4',4'-tert-butylphenylmethyl, to processes for the preparation of said nucleosides and nucleotides, to a process for the preparation of oligonucleotides, and to the use of said protected nucleosides, nucleotides and oligonucleotides.

专利号:WO-9800434-A1
优先权日:1996-06-28
标 题:Modified oligonucleotides
发明人：DE MESMAEKER ALAIN; WENDEBORN SEBASTIAN; LEBRETON JACQUES
权利人:CIBA GEIGY AG; MESMAEKER ALAIN DE; WENDEBORN SEBASTIAN; LEBRETON JACQUES
摘要:It is one object of the present invention to provide an oligonucleotide of formula (1): 5'-(U)n-3' in which U is an identical or different radical of a natural or a synthetic nucleoside, wherein the oligonucleotide comprises at least one modified nucleotide dimer comprising two nucleoside analogs connected via an amide-bond that has a certain configuration; the synthesis of these compounds and their use in pharmaceutical preparations.

专利号:WO-9738114-A1
优先权日:1996-04-09
标题 :Puromycin-sensitive aminopeptidases
发明人：FONTANA ADRIANO; CONSTAM DANIEL BEAT; TOBLER ANDREAS RUDOLF; ALTMANN KARL-HEINZ; SCHLAPBACH RALPH
权利人:CIBA GEIGY AG; FONTANA ADRIANO; CONSTAM DANIEL BEAT; TOBLER ANDREAS RUDOLF; ALTMANN KARL HEINZ; SCHLAPBACH RALPH
摘要:The present invention relates to puromycin-sensitive aminopeptidases, antibodies generated against said aminopeptidases, and to means and methods for the production thereof. The invention is also directed to nucleic acids coding for said aminopeptidases, and fragments thereof, to methods of obtaining such nucleic acid molecules or fragments of the invention, and to systems suitable for the expression of such nucleic acids. One particular aspect of this invention relates to deoxyribo- and ribo-oligonucleotides and derivatives thereof, as well as pharmaceutical preparations, therapies, diagnostics and commercial research reagents in relation to disease states which respond to modulation of the synthesis of the enzyme puromycin-sensitive aminopeptidase (PSA).