CAS: 116498-58-9; 4-((2S,3R,4R)-4-(4-Hydroxy-3,5-Dimethoxybenzyl)-3-(Hydroxymethyl)Tetrahydrofuran-2-yl)-2,6-Dimethoxyphenol

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CAS号573-44-4 丁香脂素二葡萄糖苷

📜(8R,7's,8'r)-5,5'-Dimethoxylariciresinol 9'-O-α-L-Rhamnopyranoside置于naringinase From Penicillum体系中,用 水 用作溶剂,化学反应 24.0H,反应生成5,5'-二甲氧基落叶松脂素
参考文献:Lignan Glycosides From The Twigs Of Chaenomeles Sinensis And Their Biological Activities
标题:Lignan Glycosides From The Twigs Of Chaenomeles Sinensis And Their Biological Activities
摘要:Phytochemical Investigation Of The Twigs Of Chaenomeles Sinensis Led To The Isolation And Identification Of Six New Lignan Glycosides,Chaenomiside A-F (1-6),Along With Five Known Ones (7-11). Their Chemical Structures Were Determined By Spectroscopic Methods,Including NMR,Ms,Ecd,And Gc/ms Analyses. All The Isolated Compounds (1-11) Were Tested For Their Inhibitory Effects On Nitric Oxide (No) Production In Lipopolysaccharide-Activated Murine Microglial Cells And The Secretion Of Nerve Growth Factor (Ngf) In A C6 Rat Glioma Cell Line. Compound 6 Significantly Reduced No Levels In The Murine Microglia Bv2 Cells With An Ic50 Value Of 21.3 Mu M,And Compounds 1,3,And 6 Were Potent Stimulants Of Ngf Release With Stimulation Levels Of 151.74 +/-6.77%,144.31 +/-7.49%,And 167.61 +/-18.5%,Respectively.
Doi:10.1021/acs.Jnatprod.5B00090

专利信息

专利号:EP-1493431-B1
优先权日:2003-07-03
标题:Use of an extract of bauhinia for the preparation of pharmaceutical and cosmetic compositions
发明人：WIRTH CORINNA DR; BUCHHOLZ HERWIG DR
权利人:MERCK PATENT GMBH
摘要:Use of an aqueous or aqueous-alcoholic extract (A) of Bauhinia is claimed to make a composition for cosmetic or pharmaceutical treatment of skin and hair. Use of an aqueous or aqueous-alcoholic extract (A) of Bauhinia is claimed to make a composition for: (a) care, preservation or improvement of the general condition of the skin or hair; (b) prevention and/or inhibition of the aging process for human skin or hair; (c) for promoting healing of wounds; (d) for prevention and/or treatment of skin diseases associated with abnormal keratinization, and (e) for prevention and/or treatment of all malignant or benign growths of the dermis or epidermis. An independent claim is also included for a composition containing (A). ACTIVITY : Dermatological; Vulnerary; Antiseborrheic; Antipsoriatic; Cytostatic; Antiinflammatory; Virucide. MECHANISM OF ACTION : Protein glycosylation inhibitor. In a test, human fibroblasts were cultured in the presence of Vitamin C to stimulate collagen synthesis, then lysed and labeled with tritiated glucose for 15 days, Proteins were removed, extraction and precipitation were carried and the amount of bound glucose measured by liquid scintillation counting. Addition of an aqueous-alcoholic extract of Bauhinia fortificata (0.03 mg/ml), reduced protein glycosylation to 55% of that in a control.