专利号:US-5436143-A 优先权日:1992-12-23 标题:Method for enzymatic synthesis of oligonucleotides 发明人:HYMAN EDWARD D 摘要:Enzymatic synthesis of oligonucleotides may be performed in a single vessel without intermediate purification, by the steps of: n (a) combining a nucleotide primer sequence and a blocked nucleotide in the presence of a chain extending enzyme whereby a reaction mixture is formed containing the blocked nucleotide coupled to the nucleotide primer sequence at its 3' end; n (b) inactivating the chain extending enzyme; n (c) removing the blocking group from the primer-blocked nucleotide to form a primer-nucleotide product; and converting any unreacted blocked nucleotide to an unreactive form which is substantially less active as a substrate for the chain extending enzyme than the blocked nucleotide.
专利号:US-9951088-B2 优先权日:2012-05-09 标题 :D2 receptor modulators and methods of use thereof in the treatment of diseases and disorders 发明人:JONES PHILIP G; LEW ROBERT; SPEAR KERRY L; XIE LINGHONG 权利人:SUNOVION PHARMACEUTICALS INC 摘要:Provided herein are heteroaryl compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. In one embodiment, the compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, such as CNS disorders and neurological disorders, including, but not limited to, e.g., psychosis, schizophrenia, depression, movement disorders, and Parkinson's disease.
专利号:US-5516664-A 优先权日:1992-12-23 标题 :Enzymatic synthesis of repeat regions of oligonucleotides
专利号:US-5629177-A 优先权日:1992-12-23 标 题:Method for the enzymatic synthesis of oligonucleotides using thermostable 3'-phosphatase 发明人:HYMAN EDWARD D 摘要:An oligonucleotide is synthesized by adding a 3'-phosphate blocked nucleotide to a primer, removing the blocking group from the primer-blocked nucleotide product using a thermostable 3'-phosphatase enzyme, and repeating these steps until the desired nucleotides have been added to the primer. A suitable phosphatase enzyme for use in this method is a thermostable phosphatase derived from the hyperthermophilic archaebacterium Pyrococcus furiosus.
专利号:CN-114213323-A 优先权日:2021-12-27 标题:A kind of new synthesis process of Procaterol hydrochloride
专利号:SU-1735289-A1 优先权日:1990-05-31 标题 :Method of 8-quinolinol-n-oxide synthesis
摘要:González-Bello, C., Science of Synthesis Knowledge Updates, (2018) 1, 227. 摘要:Tomás-Gamasa, M., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 2, 15. 摘要:Ahmad, O. K.; Movassaghi, M., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 2, 195. 摘要:M.N. Al-Zagoum and C.G. Warren. J. Inorg. Nucl. Chem. 31, 3465 (1969). 摘要:Das, A.; Sarmah, B. K., Science of Synthesis: Knowledge Updates, (2024) 1, 340.