CAS: 104-12-1; 4-Chlorophenylisocyanate

相似化合物

34893-92-0 2131-55-7 5392-82-5

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CAS号32315-10-9 三光气 | CAS号106-47-8 对氯苯胺 | CAS号17738-71-5 (4-氯苯基)氨基](氧代)乙酸 | CAS号21368-28-5 4-chlorobenzoyl... | CAS号1613-88-3 4-氯-N-羟基苯甲酰胺 | CAS号74-11-3 对氯苯甲酸 | CAS号201230-82-2 carbon monoxide | CAS号100-00-5 对硝基氯苯 | CAS号41374-66-7 methyl 2-(4-chl... | CAS号940-36-3 N-(4-氯苯基)氨基甲酸甲酯 | CAS号108176-68-7 1-(2H-1,4-benzo... | CAS号108176-78-9 (3Z)-1-(4-chlor... | CAS号110311-27-8 磺氯苯脲 | CAS号14423-08-6 3-(4-chlorophen... | CAS号121485-41-4 3-(4-chlorophen... | CAS号1978-88-7 N-(4-Chlorophen... | CAS号19959-41-2 methyl 2-[(4-ch... | CAS号20983-67-9 N-(4-chlorophen... | CAS号1885-81-0 1-氯-4-异氰基苯 | CAS号35367-38-5 氟脲杀

4-Chlor-Phenylcarbamoylfluorid 以 5,5-Dimethyl-1,3-Cyclohexadiene 用作溶剂,140.0 °C,101.33 Kpa 条件下,反应 3.0H,反应生成对氯苯异氰酸酯
参考文献:一种使用胺与碳酰氟制备异氰酸酯的方法
标题:一种使用胺与碳酰氟制备异氰酸酯的方法
摘要:本发明公开了一种使用碳酰氟直接与胺反应制备相应异氰酸酯的高效合成法.该方法主要包括以下两步:(1)胺与碳酰氟以优选的配比,在密闭环境,适宜反应条件下,无水惰性有机溶剂中发生酰基化反应生成中间体氨基甲酰氟;(2)常压时,适宜反应条件下,中间体氨基甲酰氟脱氟化氢得到目标异氰酸酯.反应过程无需添加催化剂,反应条件温和,反应过程中过量的碳酰氟及使用过的溶剂高效回收套用,副产物hf收集精制后可以商品化销售.

专利信息

专利号:WO-9740025-A1
优先权日:1996-04-19
标 题 :Solid phase and combinatorial synthesis of substituted 1,2,3-triazoles and of arrays of substituted 1,2,3-triazoles
发明人：DOERWALD FLORENCIO ZARAGOZA
权利人:NOVO NORDISK AS; DOERWALD FLORENCIO ZARAGOZA
摘要:A solid phase method for the synthesis of a plurality of differently substituted 1,2,3-triazoles with a wide variety of side-chain substituents as compounds of potential therapeutic interest. The 1,2,3-triazoles are prepared by acylation of a substrate-bound primary or secondary amine with a 3-oxoalkanoic acid and reaction of the resulting amide with a primary amine under dehydrating conditions to give an enamine. Treatment of this substrate-bound enamine with a sulfonyl azide in the presence of a base gives the corresponding 1,2,3-triazoles. These may be screened on the substrate or cleaved from the substrate and then screened in solution. The efficient synthesis of a wide variety of 1,2,3-triazoles using automated synthesis technology of the present method makes these compounds attractive candidates for the generation and rapid screening of diverse triazole-based libraries. The method disclosed here provides an easy and fast access to highly diverse heterocyclic compounds of therapeutic interest, amenable to automatization.

专利号:US-4267070-A
优先权日:1979-10-30
标题:Catalyst for the synthesis of aromatic monoisocyanates
发明人：NEFEDOV BORIS K; MANOV-JUVENSKY VLADIMIR I; DERGUNOV JURY I; RYSIKHIN ANATOLY I; CHIMISHKIAN ALEXANDR L
权利人:NEFEDOV BORIS K; MANOV JUVENSKY VLADIMIR I; DERGUNOV JURY I; RYSIKHIN ANATOLY I; CHIMISHKIAN ALEXANDR L
摘要:A catalyst for the synthesis of aromatic monoisocyanates comprising 1.64 to 16.6% by weight of palladium chloride, 0.16 to 47.6% by weight of an oxide of a metal of Group VB of the periodic system, 1.5 to 81.8% by weight of an oxide of a metal of Group VI B of the periodic system, 1.64 to 89.8% by weight of pyridine or an alkylsubstituted pyridine. n The use of the catalyst according to the invention in the synthesis of aromatic monoisocyanates makes it possible to obtain a high degree of conversion of the starting compound of up to 100%, a high yield of the desired product of up to 97%, and increased productivity of the catalyst of up to 40 g of the desired product per g of PdCl 2 per hour.

专利号:US-12338202-B2
优先权日:2021-09-10
标 题 :One pot synthesis of urea (meth)acrylates
发明人：BESTGEN SEBASTIAN; BEYER SILVIA
权利人:EVONIK OPERATIONS GMBH
摘要:A one-pot synthesis of polymerizable and acyclic urea (meth)acrylates, preferably mono(meth)acrylates, can be performed via in-situ synthesis of urea alcohols or amines followed by direct reaction with a (meth)acrylate reactive diluent. The urea alcohol/amine is obtained from isocyanates and alcohols, amines, or hydroxyamines. Subsequently, the reaction with the (meth)acrylate reactive diluent takes place and the urea (meth)acrylate is directly obtained either in solution with the reactive diluent, or as a pure material after removal of the reactive diluent.

专利号:US-4460501-A
优先权日:1983-08-30
标题 :Process for the synthesis of peptides utilizing thioxanthylmethyloxycarbonyl dioxides
发明人：CARPINO LOUIS A; SEGEV DAVID
权利人:RESEARCH CORP
摘要:A composition of the formula: ##STR1## wherein X is lower alkyl, and Z is an amino acid a peptide residue or a good leaving group, the composition is adaptable as a blocking or protecting group for an amine composition useful in peptide synthesis and a method of protecting an amino group of an organic molecule during a reaction which modifies a portion of the molecule other than the protected amino group.

专利号:US-2023348657-A1
优先权日:2020-07-23
标题 :Synthesis of linear polyoxazolidinones using uretdiones as diisocyanate component
发明人：QUELL AGGELIKI; THOMAS HANS-JOSEF; ELING BEREND
权利人:BASF SE
摘要:A process for preparing a thermoplastic polymer involves reacting at least components (a) to (b), in the presence of a catalyst composition (c). Component (a) is an isocyanate composition containing at least one uretdione diisocyanate (a-i), and component (b) is an epoxide composition containing at least one diepoxide (b-i). The catalyst composition (c) contains at least one ionic liquid (c-i), preferably selected from 1-ethyl-3-methyl imidazolium bromide, 1-benzyl-3-methyl imidazolium chloride. 1-butyl-1-methylpiperidinium chloride, 1-ethyl-2,3-dimethylimidazolium bromide, 1-(2-hydroxyethyl)-3-methyl imidazolium chloride, butyl-1-methylpiperidinium acetate, or mixtures of two or more thereof. A thermoplastic polymer obtained or obtainable from the process is useful for the preparation of a fibre or a molded article or as a modifier for another thermoplastic material.

专利号:US-2009156465-A1
优先权日:2005-12-30
标题:Derivatives of beta-amino acid as dipeptidyl peptidase-iv inhibitors
发明人：SATTIGERI JITENDRA A; AHMED SHAHADAT; ANDAPPAN MURUGAIAH M S; SETHI SACHIN; SHARMA LALIMA; PAL CHANCHAL KUMAR; KANDALKAR SACHIN RAMESH; MAHAJAN DIPAK C; KISHORE KAUSHAL; BHATIA SUMATI; GADHAVE ANIL G; BANSAL VINAY S; DAVIS JOSEPH ALEXANAND
权利人:SATTIGERI JITENDRA A; AHMED SHAHADAT; ANDAPPAN MURUGAIAH M S; SETHI SACHIN; SHARMA LALIMA; PAL CHANCHAL KUMAR; KANDALKAR SACHIN RAMESH; MAHAJAN DIPAK C; KISHORE KAUSHAL; BHATIA SUMATI; GADHAVE ANIL G; BANSAL VINAY S; DAVIS JOSEPH ALEXANAND
摘要:The present invention relates to β-amino acid derivatives as dipeptidyl peptidase-IV inhibitors and the processes for the synthesis of the same. This invention also relates to pharmacological compositions containing the compounds of the present invention, and methods of treating diabetes, especially type 2 diabetes, as well as prediabetes, diabetic dyslipidemia, metabolic acidosis, ketosis, satiety disorders, and obesity. These inhibitors can also be used to treat conditions manifested by a variety of metabolic, neurological, anti-inflammatory, and autoimmune disorders like inflammatory disease, multiple sclerosis, rheumatoid arthritis; viral, cancer and gastrointestinal disorders. The compounds of this invention can also be used for treatment of infertility arising due to polycystic ovary syndrome.