CAS: 103360-04-9; (4-Fluorophenyl)Methanesulfonyl Chloride

相似化合物

163295-74-7 1939-99-7 51419-59-1

上下游产品

1-chloromethyl-4-fluorobenzene 2-(4-Fluoro-benzyl)-isothiourea; hydr°Chloride 4-Fluorobenzyl bromide 7H7FO3SC7H7FO3S tert-butyl 2-[3-{[(4-fluorobenzyl)sulfonyl]amino}-6-methyl-2-oxo-1(2H)-pyridinyl]acetate N-(6-cyano-1,2,3,4-tetrahydro-quinolin-3-yl)-C-(4-fluoro-phenyl)-methanesulfonamideN-(6-cyano-1,2,3,4-tetrahydro-quinolin-3-yl)-C-(4-fluoro-phenyl)-methanesulfonamide 4-fluorobenzophenone

📜2-(4-Fluoro-Benzyl)-Isothiourea; Hydrochloride置于次氯酸叔丁酯体系中,用 水,乙腈 用作溶剂,以97%的收率获得4-氟苯基甲磺酰氯
参考文献:次氯酸叔丁酯介导的s-烷基异硫脲盐的氧化氯化反应:磺酰氯的合成
标题:次氯酸叔丁酯介导的s-烷基异硫脲盐的氧化氯化反应:磺酰氯的合成
摘要:摘要 在中性条件下,通过简单的纯化后,通过亚氯酸叔丁酯介导的氧化氯化,将各种s-烷基异硫脲盐平稳地转化为相应的磺酰氯.除了此方法的环境和程序优势外,中性条件还可能使其适用于带有酸敏感官能团的底物.例如,在当前的中性条件下,可以中等至非常好的收率合成cbz保护的2-氨基乙烷磺酰氯,并且酸敏感的cbz保护基不受影响. 在中性条件下,通过简单的纯化后,通过亚氯酸叔丁酯介导的氧化氯化,将各种s-烷基异硫脲盐平稳地转化为相应的磺酰氯.除了此方法的环境和程序优势外,中性条件还可能使其适用于带有酸敏感官能团的底物.例如,在当前的中性条件下,可以中等至非常好的收率合成cbz保护的2-氨基乙烷磺酰氯,并且酸敏感的cbz保护基不受影响.
Doi:10.1055/s-0034-1381024

专利信息

专利号:EP-1836163-B1
优先权日:2004-12-23
标题 :Pyrrolidine derivatives for the treatment of a disease depending on the activity of renin
发明人：BREITENSTEIN WERNER; COTTENS SYLVAIN; EHRHARDT CLAUS; JACOBY EDGAR; LORTHIOIS EDWIGE LILIANE JEANNE; MAIBAUM JUERGEN KLAUS; OSTERMANN NILS; SELLNER HOLGER; SIMIC OLIVER
权利人:NOVARTIS AG
摘要:Novel 3-mono-, 3,4-di- and 3,4,4,-tri-substituted pyrrolidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on inappropriate activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on inappropriate activity of renin; the use of a compound of that class in the treatment of a disease that depends on inappropriate activity of renin; pharmaceutical formulations comprising a said substituted pyrrolidine compound, and/or a method of treatment comprising administering a said substituted pyrrolidine compound, a method for the manufacture of said substituted pyrrolidine compounds, and novel intermediates and partial steps for their synthesis are described. The substituted pyrrolidine compounds are especially of the formula I wherein the substituents are as described in the specification.

专利号:US-9771356-B2
优先权日:2012-09-21
标题 :Inhibitors of beta-hydroxylase for treatment of cancer
发明人：WANDS JACK R; DE LA MONTE SUZANNE; AIHARA ARIHIRO; OLSEN MARK JON; THOMAS JOHN-MICHAEL
权利人:RHODE ISLAND HOSPITAL; UNIV MIDWESTERN
摘要:The present invention relates to compounds which modulate (e.g., inhibit) the activity of beta-hydroxylase (e.g., Asparatyl (asparaginyl) β-hydroxylase (ASPH)), including novel 2-aryl-5-amino-3(2H)-furanone and 2-heteroaryl-5-amino-3(2H)-furanone compounds, pharmaceutical compositions thereof, methods for their synthesis, and methods of using these compounds to modulate the activity of ASPH in an a cell-free sample, a cell-based assay, and in a subject. Other aspects of the invention relate to use of the compounds disclosed herein to ameliorate or treat cell proliferation disorders.

专利号:US-7396846-B2
优先权日:2002-04-09
标题:Growth hormone secretagogues
发明人：EVERS BRITTA; GERD RUEHTER; MARTIN DE LA NAVA EVA MARIA; TEBBE MARK JOSEPH
权利人:LILLY CO ELI
摘要:This invention relates to novel compounds which are useful in the modulation of endogenous growth hormone levels in a mammal. The invention further relates to novel intermediates for use in the synthesis of said compounds, as well as novel processes employed in these syntheses. Also included are methods of treating a mammal which include the administration of said compounds.

专利号:CN-110105255-B
优先权日:2019-04-22
标 题 :Mild synthesis method of diaryl thioether