CAS: 886989-88-4; (E)-1-(Pyrrolidin-1-yl)-3-(3,4,5-Trimethoxyphenyl)Prop-2-En-1-One

英文名称(E)-1-(Pyrrolidin-1-yl)-3-(3,4,5-Trimethoxyphenyl)Prop-2-En-1-One
中文名称(E)-1-(吡咯烷-1-基)-3-(3,4,5-三甲氧基苯基)丙酸-2-烯-1-酮
IUPAC名称(E)-1-(pyrrolidin-1-yl)-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one
其它别名Piperlotine C; (2E)-1-(1-Pyrrolidinyl)-3-(3,4,5-Trimethoxyphenyl)-2-Propen-1-One; 2-Propen-1-One, 1-(1-Pyrrolidinyl)-3-(3,4,5-Trimethoxyphenyl)-, (2E)-
CAS编号886989-88-4
MFCD编号:MFCD01687666
分子式:C16H21NO4分子量:291.35
产品CID: 1904838
产品分类天然产物 → 生物碱

相似结构搜索
InChIKey: TYFKYDTUEMTUNY-VOTSOKGWSA-N
InChI=1S/C16H21NO4/c1-19-13-10-12(11-14(20-2)16(13)21-3)6-7-15(18)17-8-4-5-9-17/h6-7,10-11H,4-5,8-9H2,1-3H3/b7-6+
计算化学: 氢键受体数4.0氢键供体数*可旋转键数5.0

MSDS等安全信息

警示词Warning
危险描述H302-H315-H319-H335-
防范说明P261-P305+P351+P338-

上下游产品

pyrrolidine 3,4,5-trimethoxy-benzaldehyde ethyl (E)-3-(3,4,5-trimethoxyphenyl)acrylate (E)-3,4,5-trimethoxy-cinnamic acid

合成工艺路线路线简述

20329-98-0 = 886989-88-4
反应条件:1.1 Reagents: Triethylamine,Pivaloyl Chloride Solvents: Dichloromethane; 45 Min,0 °C1.2 2 H,Rt1.3 Reagents: Sodium Bicarbonate Solvents: Water; Rt
标题:Synthesis And Biological Evaluation Of New Piplartine Analogues As Potent Aldose Reductase Inhibitors (Aris)
作者:Rao,Vidadala Ramasubba; Muthenna,Puppala; Shankaraiah,Gundeti; Akileshwari,Chandrasekhar; Babu,Kothapalli Hari; Et Al
参考文献:European Journal Of Medicinal Chemistry 日期:2012 卷标:57 页码:344-361]

20329-98-0 = 886989-88-4
反应条件:1.1 Reagents: Triethylamine,Azidotrimethylsilane Solvents: Dimethylformamide; 10 Min,Rt1.2 0 °C; 2 - 8 H,Rt
标题:Trimethylsilyl Azide-Promoted Acid-Amine Coupling: A Facile One-Pot Route To Amides From Carboxylic Acids And Amines
作者:Tangella,Yellaiah; Soni,Jay Prakash; Shankaraiah,Nagula; Abril,Diana; Sathish,Manda
参考文献:Arkivoc (Gainesville 日期:2023 卷标:(6)]

20329-98-0 = 886989-88-4
反应条件:1.1 Reagents: Triethylamine Solvents: Dichloromethane; Rt -> 0 °C1.2 Reagents: Pivaloyl Chloride Solvents: Dichloromethane; 0 °C; 2 H,0 °C1.3 0 °C -> Rt; Overnight,Rt
标题:Process For Preparation Of Piperlongumine And Analogues
参考文献:China]

20069-09-4 = 886989-88-4
反应条件:1.1 Catalysts: Dibromo[1,1′-Oxybis[ethane]]Magnesium Solvents: Acetonitrile; 8 H,Rt
标题:Unprecedented Intermolecular Transamidation Reaction Of Piplartine
作者:Gowri,P. Mangala; Radhakrishnan,S. V. S.; Rao,V. Rama Subba; Madnu,A.; Hymavathi,A.; Et Al
参考文献:Current Science 日期:2015 卷标:109(10) 页码:1775-1777]

20329-98-0 = 886989-88-4
反应条件:1.1 Reagents: Triethylamine,1-Hydroxybenzotriazole,1-Ethyl-3-(3′-Dimethylaminopropyl)Carbodiimide Hydrochloride Solvents: Dichloromethane; 30 Min,Rt1.2 24 H,Rt
标题:Synthesis And Evaluation Of A Series Of 3,4,5-Trimethoxycinnamic Acid Derivatives As Potential Antinarcotic Agents
作者:Jung,Jae-Chul; Moon,Sohyeon; Min,Dongguk; Park,Woo Kyu; Jung,Mankil; Et Al
参考文献:Chemical Biology & Drug Design 日期:2013 卷标:81(3) 页码:389-398]

2033-24-1 + 86-81-7 = 886989-88-4
反应条件:1.1 Solvents: Toluene; 8 H,110 °C
标题:Rapid Access To Cinnamamides And Piper Amides Via Three Component Coupling Of Arylaldehydes,Amines,And Meldrum'S Acid
作者:Ghosh,Santanu; Jana,Chandan K.
参考文献:Green Chemistry 日期:2019 卷标:21(21) 页码:5803-5807]

86-81-7 + 66932-75-0 = 886989-88-4
反应条件:1.1 Reagents: Potassium Carbonate; 70 Min,Rt
标题:First Mechanosynthesis Of Piperlotines A,C,And Derivatives Through Solvent-Free Horner-Wadsworth-Emmons Reaction
作者:Ramirez-Marroquin,Oscar Abelardo; Manzano-Perez,Flavio; Lopez-Torres,Adolfo; Hernandez-Lopez,Alejandro; Cortes-Pacheco,Abimelek; Et Al
参考文献:Synthetic Communications 日期:2019 卷标:49(2) 页码:244-255