CAS: 6080-33-7; Sinomenine Hydrochloride

专利信息

专利号:US-8557837-B2
优先权日:2010-02-10
标题:Sinomenine derivatives, synthetic methods and uses thereof
发明人：YAO ZHUJUN; SUN BING; LOU YANGTONG; YANG ZHENYU; CHEN AIZHONG; MA ZHAO
权利人:YAO ZHUJUN; SUN BING; LOU YANGTONG; YANG ZHENYU; CHEN AIZHONG; MA ZHAO; SHANGHAI INST ORGANIC CHEM; SHANGHAI INST BIOL SCIENCES
摘要:The invention relates to sinomenine derivatives, methods for their synthesis and their applications. The sinomenine derivatives include oxidation derivatives, and C-10 substituted sinomenine derivatives. Based on the readily oxidizable phenol group on sinomenine structure, using oxidation, oxidative dearomatization, or conjugated addition aromatization, one can introduce C-10 substitutions to synthesize the sinomenine derivatives. The sinomenine derivatives of the invention have the following structures: n n n n n n n n n n Using in vitro TNF-α inhibition assay, the activities of the synthetic compounds are assessed. Results from these assays shown that most compounds have anti-inflammatory effects, and some compounds have better activities than that of sinomenine. These compounds may be used in treating immune diseases such as rheumatoid arthritis (RA).

专利号:CN-112573978-A
优先权日:2019-09-30
标题 :A kind of efficient halogenation synthesis method of aryl halide

专利号:CN-112573978-B
优先权日:2019-09-30
标题 :A kind of efficient halogenation synthesis method of aryl halide

专利号:CN-101798285-A
优先权日:2010-02-10
标 题:A kind of sinomenine derivative, synthesis method and application thereof

专利号:CN-101798285-B
优先权日:2010-02-10
标 题 :A kind of sinomenine derivative, synthesis method and application thereof