CAS: 5842-00-2; 2-(Butylamino)Ethanethiol

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CAS号5628-96-6 ethyl 2-sulfany... | CAS号109-73-9 正丁胺 | CAS号420-12-2 环硫乙烷 | CAS号3326-89-4 1,3-氧杂硫异戊酮

📜环硫乙烷,正丁胺 反应生成 2-N-丁氨基乙硫醇
参考文献:Thiazolidine Chemistry. Iii. The Preparation And Reduction Of Some 2-Phenyl-3-N-Alkyl-4-Thiazolidinones1-3
标题:Thiazolidine Chemistry. Iii. The Preparation And Reduction Of Some 2-Phenyl-3-N-Alkyl-4-Thiazolidinones1-3
摘要:
DOI:10.1021/ja01574A036

专利信息

专利号:WO-2018146166-A1
优先权日:2017-02-07
标 题:Heterobifunctional linkers for modifying thiols
发明人：EKSTEEN JACOBUS JOHANNES; SENGEE MYAGMARSUREN; SYDNES LEIV KRISTEN
权利人:NORUT NORTHERN RES INSTITUTE AS
摘要:The invention relates to certain compounds of formula (I) (I) wherein Y is an electron-withdrawing group; Q is (formula) Z is a leaving group; J is NR5, with R5 being hydrogen or a substituted or unsubstituted alkyl, alkenyl, alkynyl or aryl group. R1 to R4 optional substituents and m is an integer between 1 and 12; n is an integer between 0 and 4; o is between 0 and 4. These compounds are useful as linkers for realisably joining a targeting moiety such as an antibody to a 'cargo' compound such as a drug, particularly an anti-cancer drug. The invention also relates to conjugates of a targeting moiety and a drug utilising the linker, to methods of synthesis of the linker and to processes for the production of the conjugate. The use of the conjugate in the treatment of disease such as cancer is also disclosed.

专利号:WO-2024077009-A1
优先权日:2022-10-03
标题 :Functionalized macromolecules and systems, methods of synthesis, and uses thereof
发明人：XIA HONGWEI; O'BRIEN EVAN; FABER-RICO JACOB; STOLARCZYK CRAIG; SIDDIQUI ASIM; YASUN EMIR; HOSSEINI NASSAB NILOUFAR
权利人:SEER INC
摘要:Disclosed herein are macromolecules, compositions thereof, and methods of making the same. In one aspect, the macromolecule are immobilized to a surface. In one aspect, provided herein are compositions, systems and kits comprising the macromolecules.