CAS: 54648-79-2; Methyl N,N'-Bis(1-Methylethyl)Carbamimidate

相似化合物

63460-32-2 60683-30-9 71432-55-8

上下游产品

methanol diisopropyl-carbodiimide glycolic acid methyl ester(2S,3R)-2,3-dihydroxy-4-(trimethylammonium)butanoate Anthopleurine 1-hydroxy-8-methoxyanthraquinone

📜羟乙酸甲酯,N,N'-二异丙基碳二亚胺置于copper Dichloride体系中,用 丙酮 作为反应溶剂,化学反应生成 N,N'-二异丙基-O-甲基异脲
参考文献:Schmidt,E.; Carl,W.,Justus Liebigs Annalen Der Chemie,1961,Vol. 639,P. 24-31
标题:Schmidt,E.; Carl,W.,Justus Liebigs Annalen Der Chemie,1961,Vol. 639,P. 24-31

专利信息

专利号:US-6063919-A
优先权日:1998-08-14
标题:Process for the synthesis of exochelins
发明人：GAUDIOSO LARRY A; WEGLARZ MICHAEL A
权利人:KEYSTONE BIOMEDICAL INC
摘要:A process for the synthesis of an Exochelin comprising the steps of generating L-N-[(2-benzyloxy-(benzoyl)] serine or L-N-[2-benzyloxy (benzoyl)] threonine, creating L-N-t-Boc- epsilon -hydroxynorleucine and reacting same to produce L-N-Boc- epsilon -bromonorleucine trimethylsilylethyl ester, providing a dicarboxylic acid and forming an O-benzyl methyl hydroxamate from the dicarboxylic acid, coupling the O-benzyl methyl hydroxamate with the L-N-Boc- epsilon -bromonorleucine trimethylsilylethyl ester to give an L-N2-Boc-N6-methyl,N6-(benzyloxy) lysine 2-trimethylsilylethyl ester which incorporates the dicarboxylic acid as modified above, removing the N-tert-butoxycarbonyl protecting group from the L-N2-Boc-N6-methyl, N6-(benzyloxy) lysine 2-trimethylsilylethyl ester to yield a substituted lysine, and coupling the same with the L-N-[2-benzyloxy (benzoyl) serine or -threonine to yield a 2-trimethyl silylethyl ester of dibenzyl Exochelic acid, transforming the 2-trimethyl silylethyl ester of dibenzyl Exochelic acid to dibenzyl Exochelic acid, preparing benzyl epi-cobactin, forming an ester bond between the dibenzyl Exochelic acid and benzyl epi-cobactin to form an intermediate, and, hydrogenolytically removing three benzyl groups from said intermediate, resulting in the synthesized Exochelin. More particularly, a synthesis for Exochelin 786SM (R) is disclosed wherein the dicarboxylic acid is suberic acid and the serine form is utilized.

专利号:US-9802952-B2
优先权日:2013-07-15
标 题:Method and apparatus for the synthesis of dihydroartemisinin and artemisinin derivatives
发明人：KOPETZKI DANIEL; MCQUADE DAVID TYLER; SEEBERGER PETER H; GILMORE KERRY
权利人:MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WSS E V; MAX-PLANK-GESELLSCHAFT ZUR FÖRDERUNG DER WSS E V
摘要:The present invention is directed to a method for continuous production of dihydroartemisinin and also artemisinin derivatives derived from dihydroartemisinin by using artemisinin or dihydroartemisinic acid (DHAA) as starting material as well as to a continuous flow reactor for producing dihydroartemisinin as well as the artemisinin derivatives. It was found that the reduction of artemisinin to dihydroartemisinin in a continuous process requires a special kind of reactor and a special combination of reagents comprising a hydride reducing agent, at least one activator such as an inorganic activator, at least one solid base, at least one aprotic solvent and at least one C 1 -C 5 alcohol.

专利号:WO-0009547-A1
优先权日:1998-08-14
标题:Novel process for the synthesis of exochelins

专利号:US-2016145265-A1
优先权日:2013-07-15
标题:Method and apparatus for the synthesis of dihydroartemisinin and artemisinin derivatives

专利号:CZ-2001530-A3
优先权日:1999-08-11
标 题:Process for the synthesis of exochelins

专利号:EP-3022208-B1
优先权日:2013-07-15
标 题:Method and apparatus for the synthesis of dihydroartemisinin and artemisinin derivatives