CAS: 452-70-0; 4-Fluoro-3-Methylphenol

上下游产品

CAS号14472-14-1 4-溴-3-甲基苯酚 | CAS号108-39-4 间甲酚 | CAS号2219-72-9 4-tert-butyl-m-... | CAS号2835-99-6 4-氨基-3-甲基苯酚 | CAS号2338-54-7 4-氟-3-甲基苯甲醚 | CAS号102-50-1 2-甲基-4-甲氧基苯胺 | CAS号1001095-14-2 3-甲基-4-氟苯氧甲酰氯

2-甲基-4-甲氧基苯胺置于氢溴酸,溶剂黄146体系中,化学反应生成 4-氟-3-甲基苯酚
参考文献:Dat-Xuong,N. Et Al.,Chimica Therapeutica,1967,Vol. 2,P. 53-56
标题:Dat-Xuong,N. Et Al.,Chimica Therapeutica,1967,Vol. 2,P. 53-56

专利信息

专利号:US-10040752-B2
优先权日:2015-08-24
标 题 :Synthesis of levomethadone hydrochloride or dextromethadone hydrochloride and methods for use thereof
发明人：MKRTCHYAN GNEL; YAO QINGWEI
权利人:CODY LABORATORIES INC
摘要:Highly efficient methods for synthesis of levomethadone hydrochloride or dextromethadone hydrochloride are provided starting from D-alanine, or L-alanine, respectively, with retention of configuration. Methods for treating a subject are provided comprising administering a composition comprising an effective amount of levomethadone hydrochloride having not more than 10 ppm dextromethadone.

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:US-2019002394-A1
优先权日:2015-08-24
标 题 :Synthesis of levomethadone hydrochloride or dextromethadone hydrochloride and methods for use thereof

专利号:US-12221427-B2
优先权日:2020-05-11
标 题:Preparation method of (5-fluoro-2,3-dihydrobenzofuran-4-yl)methanamine or its salt, and intermediates thereof
发明人：WU QINGQUAN; WANG XIULING; WANG JIAWEI; ZHOU RUBIN
权利人:ASCENTAGE PHARMA SUZHOU CO LTD; ASCENTAGE PHARMA GROUP CORP LTD
摘要:The present invention provides a preparation method of (5-fluoro-2,3-dihydrobenzofuran-4-yl)methylamine or a salt thereof, which uses 4-fluoro-3-methylphenol as the starting material, and is carried out through the steps of bromination, O-alkylation, cyclization, bromination, azidation or ammonolysis, and reduction. The reaction route of the present invention has simple synthesis process, convenient operation, high yield, and is environmentally friendly. The prepared (5-fluoro-2,3-dihydrobenzofuran-4-yl)methylamine can be used as an intermediate in pharmaceuticals and fine chemicals.

专利号:US-2017057909-A1
优先权日:2015-08-24
标 题 :Synthesis of levomethadone hydrochloride or dextromethadone hydrochloride and methods for use thereof

专利号:EP-3341354-A1
优先权日:2015-08-24
标 题 :Synthesis of levomethadone hydrochloride or dextromethadone hydrochloride and methods for use thereof