CAS: 40052-13-9; 3-Tert-Butoxy-3-Oxopropanoic Acid

相似化合物

1071-46-1 42726-73-8 541-16-2

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CAS号124-63-0 甲基磺酰氯 | CAS号75-65-0 叔丁醇 | CAS号32864-38-3 丙二酸叔丁基乙酯 | CAS号141-82-2 丙二酸 | CAS号2033-24-1 丙二酸环(亚)异丙酯 | CAS号24424-99-5 二碳酸二叔丁酯 | CAS号540-88-5 醋酸叔丁酯 | CAS号4303-71-3 SODIUM, TRIPHEN... | CAS号42726-73-8 丙二酸叔丁基甲酯 | CAS号72594-86-6 丙二酸苄酯叔丁酯 | CAS号42726-73-8 丙二酸叔丁基甲酯 | CAS号141-82-2 丙二酸 | CAS号124-38-9 二氧化碳 | CAS号115-11-7 2-甲基丙烯 | CAS号28009-80-5 3-氧化戊二酸二叔丁酯 | CAS号28009-82-7 Dibenzyl acetyl... | CAS号845883-04-7 E-Caffeic acid-... | CAS号42998-54-9 3-氨基-3-氧丙酸叔丁酯 | CAS号53075-12-0 tert-butyl 3-ch...

醋酸叔丁酯置于乙醚,氨,Sodium Amide体系中,化学反应生成 丙二酸单叔丁酯
参考文献:Hauser; Levine; Kibler,Journal Of The American Chemical Society,1946,Vol. 68,P. 27
标题:Hauser; Levine; Kibler,Journal Of The American Chemical Society,1946,Vol. 68,P. 27

专利信息

专利号:US-4189583-A
优先权日:1978-04-26
标题 :Synthesis of 4A-aryl-decahydroisoquinolines
发明人：GLESS RICHARD D; RAPOPORT HENRY; WELLER DWIGHT D
权利人:U S OF AMERICA HEW SECRETARY
摘要:This invention relates to a process for the production of 4a-aryldecahydroisoquinolines where the aryl group is selected as 3-methoxy phenyl. These compounds are morphine analogs and show utility similar to the known morphine, codeine, and thebaine. In this process particular novelty is asserted for the production of a nipecotic ester ethyl 4-(3'-methoxyphenyl)-1-methyl piperidine-3-carboxylate. Furthermore, novelty is asserted for the step of conversion of the nipecotates through cyclization to cis- or trans-tert-butyl 1,6-dioxo-4a-(3'-methoxyphenyl)-2-methyldecahydroisoquinoline-7-carboxylate, which may also be easily converted to the keto amide, trans-1,6-dioxo-4a-(3'-methoxyphenyl)-2-methyldecahydroisoquinoline.

专利号:WO-2013057186-A1
优先权日:2011-10-19
标题 :Photolabile linker for the synthesis of hydroxamic acids
发明人：NIELSEN THOMAS E; QVORTRUP KATRINE
权利人:UNIV DANMARKS TEKNISKE
摘要:The present invention relates to a photolabile hydroxamate linker based on the o - nitroveratryl group and its application for multistep solid-phase synthesis and controlled photolytic release of hydroxamic acids. The invention provides a method for producing a solid support comprising a hydroxylamine - functionalized photolabile linker, and the so produced hydroxylamine - functionalized photolabile solid support. The invention further provides a method for synthesizing a one-bead-one compound library of hydroxamic acid derivatives on a photolabile linker, as well as a method for screening a library of hydroxamic acid derivatives.

专利号:WO-2007096751-A1
优先权日:2006-02-21
标题 :Process for the preparation of atorvastatin calcium
发明人：PATEL DHIMANT JASUBHAI; KUMAR RAJIV; DWIVEDI SHRI PRAKASH DHAR
权利人:CADILA HEALTHCARE LTD; PATEL DHIMANT JASUBHAI; KUMAR RAJIV; DWIVEDI SHRI PRAKASH DHAR
摘要:The present invention relates to process for the preparation of atorvastatin calcium. The process provides the novel approach for the synthesis of an important intermediate atorvastatin protected diol chemically (4R-cis)-6-[-2-[3-phenyl-4-(phenyl- carbamoyl)-2-(4-flourophenyl)-5-(1-methyl-ethyl)-pyrrol-1-yl]-ethyl]-2,2-dimethyl- [1,3]dioxane-4-yl-acetic acid-tertriay butyl ester for atorvastatin calcium i.e. [R- (R*,R*)]-2-(4-fluorophenyl-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4- [(phenylamino) carbonyl]-1H-pyrrole-1-heptanoic acid calcium salt (2:1). The present invention relates the use of amino side chain i.e [6-(2-aminoethyl)-2,2,-dimethyl- [1,3]dioxan-4-yl]-acetic acid tert-butyl ester and stetter compound i.e. 4-(4- FluoroÏ?henyl)-2-isobutryl-4-oxo-N-phenyl butryl amide as an important starting materials for the preparation of atorvastatin protected diol in the high yield and thereby the recovery of amino side chain with an industrially applicable process.

专利号:US-4283536-A
优先权日:1977-12-29
标 题:Preparation of vincadifformine and related derivatives
发明人：KUEHNE MARTIN E
权利人:UNIV VERMONT
摘要:This invention relates to the preparation of vincadifformine and related derivatives which are useful as starting material for the synthesis of among other alkaloids vincamine and other similar compounds possessing interesting psychopharmacologic properties. n A tetrahydro-β-carboline (II) is reacted with benzoyl chloride to provide a 2-benzoyl-1,2,3,4-tetrahydro-9H-pyrido-(3,4-b)-indole (III). Then compound (III) is reduced to give a 2-benzyl-1,2,3,4-tetrahydro-9H-pyrido-(3,4-b)-indole (IV). Thereafter, compound (IV) is transformed by t-butyl hypochlorite into a chloroindolenine derivative (V) which is immediately treated with a metal dialkylmalonate such as thallium t-butyl methyl malonate to give a dialkyl 3-benzyl-1,2,3,4,5,6-hexahydroazepino-(4,5-b)-indole-5,5-dicarboxylate (VI). Compound (VI) is then partly decarboxylated into a alkyl 3-benzyl-1,2,3,4,5,6-hexahydro-(4,5-b) indole-5-carboxylate (VII). Compound (VII) is hydrogenated to give an alkyl 1,2,3,4,5,6-hexahydroazepino-(4,5-b)-indole 5-carboxylate (VIII). In an alternative embodiment, compound (VI) can be hydrogenated to the corresponding dialkyl 1,2,3,4,5,6-hexahydroazepino-(4,5-b)-indole-5,5-dicarboxylate which is then decarboxylated into compound (VIII). Compound (VIII) is condensed with a functionalised aldehyde, typically a epoxy aldehyde or a haloaldehyde such as 1-bromo-4-formylhexane, to give vincadifformine or similar pentacyclic derivatives.

专利号:US-4435572-A
优先权日:1978-04-26
标题:Synthesis of ethyl-4(3'-methoxyphenyl)-1-methyl piperidine-3-carboxylate
发明人：RAPOPORT HENRY; WELLER DWIGHT D; CLESS RICHARD D
权利人:US HEALTH
摘要:This invention relates to a process for the production of 4a-aryldecahydroisoquinolines where the aryl group is selected as 3-methoxy phenyl. These compounds are morphine analogs and show utility similar to the known morphine, codeine, and thebaine. In this process particular novelty is asserted for the production of a nipecotic ester ethyl 4-(3'-methoxyphenyl)-1-methyl piperidine-3-carboxylate. Furthermore, novelty is asserted for the step of conversion of the nipecotates through cyclization to cis- or trans-tert-butyl 1,6-dioxo-4a-(3'-methoxyphenyl)-2-methyldecahydroisoquinoline-7-carboxylate, which may also be easily converted to the keto amide, trans-1,6-dioxo-4a-(3'-methoxyphenyl)-2-methyldecahydroisoquinoline.

专利号:US-7652168-B2
优先权日:2001-07-10
标 题 :Synthesis of taxol enhancers
发明人：CHEN SHOUJUN; SUN LIJUN; XIA ZHI-QIANG; KOVA KEIZO; ONO MITSUNORI
权利人:SYNTA PHARMACEUTICALS CORP
摘要:Disclosed is a method of preparing a thiohydrazide product compound from a hydrazide starting compound. The hydrazide starting compound is represented by Structural Formula (I): n nThe thiohydrazide product compound is represented by Structural Formula (II):n n nIn Structural Formulas (I)-(II), R 1 and R 2 are independently an aliphatic group, a substituted aliphatic group, an aryl group or a substituted aryl group, or R 1 and R 2 taken together with the carbon and nitrogen atoms to which they are bonded, form a non-aromatic heterocyclic ring optionally fused to an aromatic ring. When R 2 is an aryl group or a substituted aryl group, then R 5 is a hydrazine protecting group; and when R 2 is an aliphatic or substituted aliphatic group, then R 5 is —H or a hydrazine protecting group. R 10 is —H or a substituted or unsubstituted alkyl group. The method comprising the step of reacting the starting compound with a thionylating reagent.