CAS: 35450-36-3; Methyl 2-Bromo-5-Methoxybenzoate

上下游产品

CAS号67-56-1 甲醇 | CAS号22921-68-2 2-溴-5-甲氧基苯甲酸 | CAS号1083407-17-3 N,5-dihydroxy-2... | CAS号75-91-2 叔丁基过氧化氢 | CAS号5368-81-0 3-甲氧基苯甲酸甲酯 | CAS号74-88-4 碘甲烷 | CAS号42523-29-5 2,7-二羟基-9-芴酮 | CAS号216367-16-7 2-(4-fluorophen... | CAS号1088995-25-8 2,6,11-trimetho... | CAS号5368-81-0 3-甲氧基苯甲酸甲酯 | CAS号81747-26-4 2,2'-bis(methox... | CAS号127510-95-6 2-氰基-5-甲氧基苯甲酸甲酯 | CAS号154607-00-8 2-溴-5-羟基苯甲酸甲酯 | CAS号3133-07-1 9H-Fluoren-9-on... | CAS号150192-39-5 2-溴-5-甲氧基苯甲醇 | CAS号1262010-81-0 2-(2-formylphen...

📜2-溴-5-甲氧基苯甲酸置于硫酸体系中,用 甲醇,乙酸乙酯 用作溶剂,化学反应生成2-溴-5-甲氧基苯甲酸甲酯
参考文献:Fused Cycloheptane And Fused Azacycloheptane Compounds And Their Methods Of Use
标题:Fused Cycloheptane And Fused Azacycloheptane Compounds And Their Methods Of Use
摘要:该发明涵盖了新颖的化合物,对预防和治疗疾病有效,例如通过整合素受体介导的疾病,特别是通过整合素受体介导的疾病或症状,如αvβ3,αvβ5,αvβ6等.该发明涵盖了新颖的化合物,其药学上可接受的盐,药物组合物以及预防和治疗此类疾病和疾患的方法.该发明还涉及制备此类化合物的方法以及在此类方法中有用的中间体.

专利信息

专利号:WO-2024159287-A1
优先权日:2023-01-30
标 题:Nav1.7- and/or nav1.8-inhibiting hydroxamates, processes for the preparation thereof, compositions, uses, methods for treatment using same, and kits
发明人：BARREIRO GABRIELA; SANT’ANA DANILO PEREIRA DE; MONTEIRO JÚLIA LAMMOGLIA; GAMBA LUIS EDUARDO REINA; LIMA LÃ?DIA MOREIRA; FRAGA CARLOS ALBERTO MANSSOUR; BARREIRO ELIEZER JESUS DE LACERDA
权利人:EUROFARMA LABORATORIOS S A; UNIV FEDERAL DO RIO DE JANEIRO – UFRJ
摘要:The invention relates to Nav1.7- and/or Nav1.8-inhibiting hydroxamates. More specifically, the present invention relates to hydroxamates that comprise formula (I): (I), in which the substituents R1 to R10, as well as the derivatives thereof, R11 to R20, are selected independently of the groups defined in the description, as well as to the processes for the preparation thereof, compositions comprising at least one of said compounds, uses, treatment methods for treating or preventing pain-related pathologies, and kits. The present invention pertains to the fields of medicinal chemistry and organic synthesis, as well as to the treatment of pain-related disorders.

专利号:US-5258407-A
优先权日:1991-12-31
标题 :3,4-disubstituted phenols-immunomodulating agents
发明人：WASHBURN WILLIAM N; LUSSIER BARBARA B; ILLIG CARL B; LATIMER LEE H
权利人:STERLING WINTHROP INC
摘要:Certain 3,4-disubstituted phenols and pharmaceutically acceptable salts thereof are provided which mimic IL-1 activity by inducing IL-2 synthesis and subsequent IL-2 receptor expression. Specifically, the invention provides compounds of Formula I and acid addition salts thereof: FORMULA I wherein Y is NHSO2 or SO2NH where R4 is H; Z is -O-, -NH-, -NR-, -S-, or other heteroatoms capable of hydrogen bonding with R4 to give a preferred conformation; R is alkyl; R1 is -OH; R2 is H, alkyl, cycloalkyl, aralkyl, substituted or unsubstituted aryl, or a substituted or unsubstituted nitrogen heterocyclic group having 4 to 5 nuclear carbon atoms; and R3 is a lipophilic moiety.

专利号:US-5466715-A
优先权日:1991-12-31
标题:3,4-disubstituted phenols-immunomodulating agents
发明人：WASHBURN WILLIAM N; LUSSIER BARBARA B; ILLIG CARL R; LATIMER LEE H
权利人:STERLING WINTHROP INC
摘要:Certain 3,4-disubstituted phenols and pharmaceutically acceptable salts thereof are provided which mimic IL-1 activity by inducing IL-2 synthesis and subsequent IL-2 receptor expression. Specifically, the invention provides compounds of Formula I and acid addition salts thereof: FORMULA I wherein Y is NHSO2 or SO2NH where R4 is H; Z is -O-, -NH-, -NR-, -S-, or other heteroatoms capable of hydrogen bonding with R4 to give a preferred conformation; R is alkyl; R1 is -OH; R2 is H, alkyl, cycloalkyl, aralkyl, substituted or unsubstituted aryl, or a substituted or unsubstituted nitrogen heterocyclic group having 4 to 5 nuclear carbon atoms; and R3 is a lipophilic moiety selected from the group consisting of substituted C1-C10 alkyl, C3-C16 cycloalkyl and 2,4-di-t-pentylphenyl.